KEGG ENZYME: 1.14.13.225

ENZYME: 1.14.13.225

Entry

EC 1.14.13.225              Enzyme

Name

F-actin monooxygenase;
MICAL (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

[F-actin]-L-methionine,NADPH:O2 S-oxidoreductase

Reaction(IUBMB)

[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O [RN:R11425]

Reaction(KEGG)

R11425

Substrate

[F-actin]-L-methionine [CPD:C21377];
NADPH [CPD:C00005];
O2 [CPD:C00007];
H+ [CPD:C00080]

Product

[F-actin]-L-methionine-(R)-S-oxide [CPD:C21378];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Comment

The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization [1]. Free methionine is not a substrate [2]. The reaction is stereospecific and generates the (R)-sulfoxide [3]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1) [4,5].

History

EC 1.14.13.225 created 2016

Orthology

K19947

F-actin monooxygenase

Genes

HSA:	57553(MICAL3) 64780(MICAL1) 9645(MICAL2)

PTR:	451031(MICAL2) 463145(MICAL1) 745678(MICAL3)

PPS:	100969548(MICAL1) 100987179(MICAL3) 100994154(MICAL2)

GGO:	101127991(MICAL1) 101139251(MICAL2) 101149053(MICAL3)

PON:	100173765(MICAL1) 100438047(MICAL2) 100444220(MICAL3)

NLE:	100581557(MICAL3) 100599627(MICAL2) 100604034(MICAL1)

HMH:	116459454(MICAL3) 116470763(MICAL1) 116476503(MICAL2)

MCC:	698737(MICAL1) 701439 710292(MICAL3)

MCF:	102124064(MICAL2) 102135771(MICAL3) 102139619(MICAL1)

MTHB:

126929587 126935643 126953624

MNI:	105480748(MICAL3) 105486894 105492054(MICAL1)

CSAB:

103222878(MICAL3) 103240067(MICAL2) 103240597(MICAL1)

CATY:

105581354(MICAL1) 105591254(MICAL3) 105595703(MICAL2)

PANU:

100999634(MICAL2) 101008997(MICAL3) 101016773(MICAL1)

TGE:	112606066(MICAL2) 112622882(MICAL1) 112632620(MICAL3)

MLEU:

105533147(MICAL2) 105536563(MICAL1) 105542931(MICAL3)

RRO:	104668570 104668827(MICAL1) 104676297(MICAL3)

RBB:	108533801(MICAL1) 108535533(MICAL2) 108541715(MICAL3)

TFN:	117080870 117096064(MICAL3) 117097193(MICAL1)

PTEH:

111538558(MICAL1) 111555030

CANG:

105514347(MICAL3) 105519453(MICAL1) 105520515(MICAL2)

CJC:	100394528(MICAL2) 100395442(MICAL1) 100400227(MICAL3)

SBQ:	101027900(MICAL2) 101040006(MICAL3) 101042616(MICAL1)

CIMI:

108281729(MICAL1) 108294852(MICAL3) 108302227(MICAL2)

CSYR:

103252673(MICAL2) 103263619(MICAL3) 103274988(MICAL1)

MMUR:

105859950(MICAL2) 105861853(MICAL3) 105864963(MICAL1)

LCAT:

123633149(MICAL1) 123640173(MICAL3) 123642453(MICAL2)

PCOQ:

105815809(MICAL3) 105815925(MICAL1) 105818412(MICAL2)

OGA:	100941168(MICAL3) 100954750 100956324(MICAL1)

MMU:	171580(Mical1) 194401(Mical3) 320878(Mical2)

MCAL:

110295772(Mical3) 110299452(Mical2) 110303515(Mical1)

MPAH:

110314399(Mical3) 110318852(Mical2) 110326332(Mical1)

RNO:	294520(Mical1) 362427(Mical3) 365352(Mical2)

MCOC:

116074518(Mical1) 116099519(Mical3) 116102810(Mical2)

ANU:	117710358(Mical2) 117714636(Mical3) 117724952(Mical1)

MUN:	110541039(Mical2) 110546057(Mical3) 110555442(Mical1)

CGE:	100752579(Mical1) 100754319(Mical3) 100763886(Mical2)

MAUA:

101829614(Mical1) 101839304(Mical2) 101844880(Mical3)

PROB:

127215168(Mical1) 127228206(Mical2) 127236162(Mical3)

PLEU:

114697590(Mical2) 114700733(Mical3) 114707525(Mical1)

MORG:

121440143(Mical3) 121449337(Mical1) 121457859(Mical2)

MFOT:

126487629 126490748 126514919

AAMP:

119808170(Mical3) 119820673(Mical1) 119827053(Mical2)

NGI:	103745899(Mical3) 103749557(Mical1) 103750410(Mical2)

HGL:	101701740(Mical1) 101709910(Mical3) 101712859(Mical2)

CPOC:

100715118(Mical1) 100726239(Mical3) 100735168(Mical2)

CCAN:

109684398 109684399 109688102(Mical2) 109694751(Mical1)

DORD:

105990107(Mical1) 105991117(Mical3) 105995126(Mical2)

DSP:	122101655(Mical3) 122103969(Mical1) 122117730(Mical2)

PLOP:

125342866(Mical3) 125357062(Mical1) 125361187(Mical2)

NCAR:

124958484 124982602 124988883

MMMA:

107135657(Mical2) 107154429(Mical1) 107155038(Mical3)

OCU:	100347412 100353897 100354238

OPI:	101516967(MICAL3) 101520406(MICAL1) 101525940(MICAL2)

TUP:	102480907(MICAL3) 102486503(MICAL1) 102494378(MICAL2)

GVR:	103591690(MICAL2) 103594224(MICAL1)

CFA:	476858(MICAL2) 481958(MICAL1) 486761(MICAL3)

CLUD:

112658393(MICAL1) 112667644(MICAL2) 112668955(MICAL3)

VVP:	112917441(MICAL3) 112925126(MICAL1) 112927059(MICAL2)

VLG:	121473673(MICAL1) 121476354 121479938(MICAL3)

NPO:	129503359(MICAL3) 129504759(MICAL2) 129512648(MICAL1)

AML:	100465187(MICAL3) 100465934(MICAL2) 100478759(MICAL1)

UMR:	103675754(MICAL3) 103677024(MICAL1) 103682359

UAH:	113246261 113258066(MICAL3) 113264746(MICAL1)

UAR:	123778075(MICAL3) 123791651(MICAL2) 123792939(MICAL1)

ELK:	111158225 111159507 111159745

LLV:	125078235 125102461 125107032

MPUF:

101684119 101687316(MICAL3) 101691585(MICAL1)

MNP:	132018350(MICAL1) 132019999(MICAL3) 132022995(MICAL2)

MLK:	131809358(MICAL2) 131833519(MICAL1) 131838339(MICAL3)

NVS:	122892231(MICAL3) 122903673(MICAL1) 122912732(MICAL2)

ORO:	101366928(MICAL2) 101371709(MICAL3) 101380122(MICAL1)

EJU:	114209988(MICAL1) 114219307 114222543(MICAL3)

ZCA:	113913852 113922520(MICAL3) 113927204(MICAL1)

MLX:	118001582(MICAL1) 118004247(MICAL2) 118025826(MICAL3)

NSU:	110576240(MICAL2) 110583013(MICAL1)

LWW:	102733303(MICAL3) 102734026(MICAL1) 102742847

FCA:	101081558(MICAL3) 101091046(MICAL2) 101100722(MICAL1)

PYU:	121018204 121022012(MICAL3) 121029882(MICAL1)

PCOO:

112861982(MICAL1) 112864889(MICAL2) 112867182(MICAL3)

PBG:	122473998(MICAL3) 122483572(MICAL2) 122489850(MICAL1)

PVIV:

125146955(MICAL2) 125166179(MICAL1) 125169684(MICAL3)

LRUF:

124502356 124504691 124528602

PTG:	102951530(MICAL3) 102962220(MICAL1) 102962641(MICAL2)

PPAD:

109263525(MICAL1) 109271148 109276281(MICAL3)

PUC:	125918696 125936014 125938783

AJU:	106968456 106968890 106971840

HHV:	120235204(MICAL1) 120237523(MICAL2) 120243763(MICAL3)

BTA:	508306(MICAL1) 532244(MICAL3) 534041(MICAL2)

BOM:	102266509(MICAL2) 102273179(MICAL1) 102286656(MICAL3)

BIU:	109559784(MICAL3) 109563835(MICAL1) 109569548(MICAL2)

BBUB:

102391634(MICAL1) 102395599(MICAL3) 102401601(MICAL2)

BBIS:

104981466(MICAL2) 104992259(MICAL3) 105000704(MICAL1)

CHX:	102172084 102178522(MICAL3) 102185000(MICAL1)

OAS:	101113940(MICAL1) 101118097(MICAL3) 101121880(MICAL2)

BTAX:

128047574(MICAL3) 128053091(MICAL1) 128061027(MICAL2)

ODA:	120857828(MICAL3) 120862517(MICAL1) 120876445(MICAL2)

CCAD:

122422634(MICAL1) 122423031(MICAL3) 122450612(MICAL2)

MBEZ:

129536990(MICAL3) 129554503(MICAL2) 129561122(MICAL1)

SSC:	100153346(MICAL1) 100157721(MICAL3) 100519075(MICAL2)

CFR:	102507940 102511399(MICAL1) 102522111(MICAL3)

CBAI:

105076002(MICAL3) 105076623(MICAL2) 105077112(MICAL1)

CDK:	105086699 105097110(MICAL1) 105100736(MICAL3)

VPC:	102532262 102533183(MICAL1) 102536845(MICAL3)

BACU:

103000884(MICAL1) 103012504(MICAL3) 103012861(MICAL2)

BMUS:

118899967 118901890(MICAL3) 118905172(MICAL1)

LVE:	103069359(MICAL2) 103087508(MICAL1) 103088697(MICAL3)

OOR:	101275370(MICAL2) 101275745(MICAL3) 101285142(MICAL1)

DLE:	111164423(MICAL1) 111165227(MICAL2) 111176586(MICAL3)

PCAD:

102977044(MICAL1) 102988858(MICAL2) 102991718(MICAL3)

PSIU:

116758806 116760249(MICAL3) 116763523(MICAL1)

NASI:

112391716(MICAL3) 112406597(MICAL1) 112407716

ECB:	100054807(MICAL3) 100055978 100066627(MICAL1)

EPZ:	103551111(MICAL1) 103565092(MICAL3) 103566075

EAI:	106829758(MICAL1) 106833091(MICAL2) 106839442(MICAL3)

MYB:	102248958(MICAL2) 102251692(MICAL1) 102258499(MICAL3)

MYD:	102751644(MICAL3) 102759552(MICAL1) 102769793(MICAL2)

MMYO:

118651865(MICAL3) 118660499(MICAL1) 118664835(MICAL2)

MLF:	102416812(MICAL1) 102427093(MICAL3) 102434288(MICAL2)

PKL:	118705608(MICAL1) 118713387 118728785(MICAL3)

EFUS:

103294616(MICAL2) 103300624(MICAL1) 103303804(MICAL3)

MNA:	107535318(MICAL2) 107537711(MICAL3) 107540706(MICAL1)

DRO:	112297007(MICAL1) 112303258 112311619(MICAL3)

SHON:

118989745(MICAL2) 118995136(MICAL3) 119000160(MICAL1)

AJM:	119044370(MICAL3) 119050526(MICAL2) 119059422(MICAL1)

PDIC:

114494320(MICAL1) 114499263 114508579(MICAL3)

PHAS:

123810068(MICAL2) 123818862(MICAL3) 123822103(MICAL1)

MMF:	118621017(MICAL1) 118624452(MICAL3) 118628128(MICAL2)

PPAM:

129067694(MICAL1) 129080552(MICAL2) 129080991(MICAL3)

HAI:	109373294(MICAL3) 109388271 109391423(MICAL1)

RFQ:	117016704(MICAL1) 117029356(MICAL3) 117031043

PALE:

102887125(MICAL3) 102889705(MICAL2) 102892071(MICAL1)

PGIG:

120603214(MICAL2) 120607363(MICAL3) 120608311(MICAL1)

PVP:	105295244(MICAL1) 105297236(MICAL3) 105301471(MICAL2)

RAY:	107500353(MICAL3) 107505345(MICAL2) 107518492(MICAL1)

MJV:	108395279(MICAL2) 108406778(MICAL3)

TOD:	119247867(MICAL3) 119252765(MICAL1) 119255478(MICAL2)

SARA:

101551779(MICAL3) 101558616(MICAL2)

LAV:	100661909(MICAL3) 100663700 100665365(MICAL1)

TMU:	101340914 101352495 101356859

ETF:	101650782(MICAL2) 101658014(MICAL1) 101658909(MICAL3)

DNM:	101414165(MICAL2) 101440708(MICAL3) 101446608(MICAL1)

MDO:	100022040(MICAL3) 100029104(MICAL1) 100030142(MICAL2) 107649961

GAS:	123247707(MICAL1) 123250329(MICAL3) 123252537(MICAL2)

SHR:	100920737(MICAL1) 100922670(MICAL2) 100929940(MICAL3)

AFZ:	127538158 127540361 127562074

PCW:	110218729(MICAL3) 110218891(MICAL2) 110222901(MICAL1)

OAA:	100073551(MICAL2) 100085361(MICAL1) 100086054(MICAL3)

GGA:	418164(MICAL3) 423031(MICAL2) 429474(MICAL1)

PCOC:

116226876(MICAL3) 116238782(MICAL1) 116242975(MICAL2)

MGP:	100541969 100545712(MICAL1) 100548226 104911003(MICAL2) 104912086

CJO:	107314574(MICAL2) 107314988(MICAL3) 107324612(MICAL1)

TPAI:

128085607(MICAL2) 128090232(MICAL1)

LMUT:

125684000(MICAL1) 125688304(MICAL3) 125694918(MICAL2)

NMEL:

110388263(MICAL1) 110395577(MICAL3) 110400782(MICAL2)

APLA:

101794484(MICAL2) 101803780(MICAL1) 101805047(MICAL3)

ACYG:

106030921(MICAL3) 106040898(MICAL2) 106046127(MICAL1)

CATA:

118249852(MICAL2) 118259514(MICAL1)

AFUL:

116489487(MICAL2) 116490301(MICAL3) 116498739(MICAL1)

TGU:	100219168(MICAL3) 100227450(MICAL2) 100232670(MICAL1)

LSR:	110469104(MICAL2) 110473459(MICAL1) 110482582(MICAL3)

SCAN:

103820469(MICAL3) 103823343(MICAL1) 103824313(MICAL2)

PMOA:

120495838(MICAL1) 120501683(MICAL3) 120509914(MICAL2)

OTC:	121332813(MICAL3) 121345942(MICAL2) 121347968(MICAL1)

PRUF:

121353947(MICAL1) 121362696(MICAL3) 121363394(MICAL2)

GFR:	102032677(MICAL3) 102033849(MICAL2) 102043330(MICAL1)

FAB:	101811190(MICAL2) 101819614(MICAL3) 101820098(MICAL1)

OMA:	130254406(MICAL2) 130261838(MICAL3) 130263673(MICAL1)

PHI:	102107564(MICAL3) 102107919(MICAL2) 102108714(MICAL1)

PMAJ:

107204329(MICAL3) 107205792(MICAL2) 107214787(MICAL1)

CCAE:

111928083(MICAL3) 111930849(MICAL2) 111939748(MICAL1)

CCW:	104692251(MICAL3) 104692546 104692969(MICAL2)

CBRC:

103624698(MICAL3) 103624782(MICAL2) 103625350(MICAL1)

ETL:	114056527(MICAL2) 114065769(MICAL1) 114068977(MICAL3)

ZAB:	102066089(MICAL1) 102069145(MICAL3) 102073024(MICAL2)

ACHL:

103799117(MICAL3) 103803541(MICAL2) 103803943(MICAL1)

SVG:	106849426(MICAL3) 106851044(MICAL1) 106856830(MICAL2)

MMEA:

130582643(MICAL1) 130582975(MICAL2) 130588977(MICAL3)

HRT:	120751378(MICAL3) 120754488(MICAL2) 120762690(MICAL1)

FPG:	101914505(MICAL3) 101922313(MICAL1) 101924713(MICAL2)

FCH:	102047357(MICAL3) 102052557(MICAL2) 102060220(MICAL1)

CLV:	102085132(MICAL2) 102093478(MICAL3) 102096460(MICAL1)

EGZ:	104123406(MICAL2) 104125757(MICAL1) 104134379(MICAL3)

NNI:	104009445(MICAL2) 104013230(MICAL1) 104020203(MICAL3)

PCRI:

104027094(MICAL3) 104039063

PLET:

104624437

EHS:	104505964(MICAL2) 104515632

PCAO:

104043696 104045830(MICAL2) 104049401

ACUN:

113481325(MICAL2) 113489033(MICAL1) 113491284(MICAL3)

TALA:

104358733(MICAL3) 104363867(MICAL2) 116965567(MICAL1)

PADL:

103919887 103924360(MICAL3) 103925723(MICAL2)

AFOR:

103893727 103898655(MICAL3) 103906781(MICAL2)

ACHC:

115334805(MICAL1) 115351903(MICAL2) 115352746(MICAL3)

HALD:

104315494(MICAL3) 104322975(MICAL2)

HLE:	104829498(MICAL2) 104830922(MICAL3) 104842358(MICAL1)

AGEN:

126046917 126047644 126052449

GCL:	127016493 127026248 127029786

CCRI:

104168442(MICAL2)

CSTI:

104556584(MICAL2) 104559846

CMAC:

104477093(MICAL3)

MUI:	104536761 104544834(MICAL2)

BREG:

104634439(MICAL3) 104638606(MICAL2) 104640800(MICAL1)

FGA:	104078996(MICAL3)

GSTE:

104263774(MICAL3) 104264509(MICAL2)

LDI:	104342824(MICAL2) 104351505(MICAL3)

MNB:	103771765 103777665(MICAL3)

OHA:	104326374(MICAL2) 104337124(MICAL3)

NNT:	104407793(MICAL3) 104408471(MICAL2)

SHAB:

115602218(MICAL1) 115605748(MICAL3) 115607663(MICAL2)

DPUB:

104296675(MICAL2) 104304696(MICAL3) 104305365(MICAL1)

PGUU:

104471230(MICAL2)

ACAR:

104526452

CPEA:

104385768(MICAL2) 104393432(MICAL3) 104397186(MICAL1)

AVIT:

104271002(MICAL2) 104274576

CVF:	104281611(MICAL3) 104293172(MICAL2)

RTD:	128900240(MICAL1) 128904769(MICAL3) 128908600(MICAL2)

CUCA:

104055894(MICAL3) 104061836(MICAL2) 104064949(MICAL1)

TEO:	104379206 104383290

BRHI:

104496879(MICAL2) 104498836(MICAL3) 104500163(MICAL1)

AAM:	106487711(MICAL1) 106488631(MICAL3) 106497117(MICAL2)

AROW:

112961422(MICAL1) 112968271(MICAL3) 112974004(MICAL2)

NPD:	112943517(MICAL2) 112958345(MICAL3) 112959154(MICAL1)

TGT:	104578880(MICAL2) 104579060(MICAL1)

DNE:	112985684(MICAL2) 112990247(MICAL1) 112993396(MICAL3)

SCAM:

104147378(MICAL3) 104152068(MICAL2)

ASN:	102371980 102375438(MICAL3) 102377820(MICAL2)

AMJ:	102565781(MICAL1) 102574107(MICALCL) 106737063(MICAL3)

CPOO:

109316446(MICAL3) 109317837 109321193

GGN:	109295337(MICAL1) 109296245(MICAL3) 109299071(MICAL2)

PSS:	102443943(MICAL3) 102447311 102462749(MICAL2)

CMY:	102932362(MICAL2) 102935764(MICAL1) 102942117(MICAL3)

CCAY:

125625245 125625709(MICAL3) 125639091(MICAL2)

DCC:	119846398(MICAL1) 119856585(MICAL2)

CPIC:

101936236(MICAL1) 101936780(MICAL3) 101946730(MICAL2)

TST:	117875899(MICAL1) 117876498 117882738(MICAL3)

CABI:

116829948(MICAL1) 116830089(MICAL3) 116831648(MICAL2)

MRV:	120403291(MICAL2) 120404395(MICAL1) 120408712(MICAL3)

ACS:	100552986(mical1) 100554427(mical3) 100564862(mical2)

ASAO:

132769938(MICAL2) 132773750(MICAL1) 132775760(MICAL3)

PVT:	110076703(MICAL3) 110079674(MICAL1) 110080915(MICAL2)

SUND:

121926475(MICAL2) 121928893(MICAL1) 121931170(MICAL3)

PBI:	103048923 103058605(MICAL1) 103058722(MICAL2) 103064154

PMUR:

107289040(MICAL1) 107292277(MICAL3) 107293552

CTIG:

120298967(MICAL1) 120306686(MICAL2) 120317642(MICAL3)

TSR:	106540548 106543098 106546022 106554910 106555040

PGUT:

117655329(MICAL3) 117664022(MICAL1) 117665343(MICAL2)

APRI:

131187432(MICAL2) 131194414 131202107(MICAL3)

PTEX:

113439683(MICAL2) 113446449(MICAL3) 113446968 113447781

NSS:	113410315(MICAL2) 113418788 113418967 113419348(MICAL3)

VKO:	123021138(MICAL2) 123030031 123036086(MICAL3)

PMUA:

114597808(MICAL2) 114599198 114604933(MICAL3)

PRAF:

128415097(MICAL2) 128415977(MICAL1) 128421898(MICAL3)

ZVI:	118086880(MICAL2) 118088166(MICAL1) 118090781(MICAL3)

HCG:	128322372(MICAL1) 128322878(MICAL2) 128326284(MICAL3)

GJA:	107108023 107110968 107114958 107116309(MICAL2)

STOW:

125426590(MICAL2) 125432619(MICAL1) 125435915(MICAL3)

EMC:	129325275(MICAL2) 129329963(MICAL1) 129335282(MICAL3)

XLA:	108704384(mical3.L) 108712569(mical3.S) 108713737 108715283

XTR:	100486205(mical3) 100487018(mical2)

NPR:	108786140(MICAL2) 108791576(MICAL3)

RTEM:

120916987 120932722(MICAL3)

BBUF:

120980982(MICAL2) 121004621(MICAL3)

BGAR:

122920224(MICAL2) 122928479(MICAL3)

MUO:	115468873(MICAL2) 115477148(MICAL3) 115481756(MICAL1)

GSH:	117347228(MICAL1) 117352145(MICAL2) 117363346(MICAL3)

DRE:	402881(mical3a) 566850(mical3b) 568573(mical1) 569564(mical2b) 569607(mical2a)

SRX:	107707484 107722450 107726023 107727100 107730085 107738397 107738415 107743961 107745933 107754885

SANH:

107654348 107656292 107658814 107664200 107672585 107673136 107686639 107686850 107697883 107701044

SGH:	107558750 107559327 107562792 107572458 107581280 107584726 107587046 107589188 107590487 107592209

CCAR:

109054397 109057386 109057463 109057741 109069974 109079851 109082941 109109594 109109600 109109904

CAUA:

113041277 113043106 113048312 113051769 113059278 113060030 113061528 113065630 113065666 113066852 113068816 113097201 113106480 113118209

CGIB:

127933893 127944930 127947215 127956889 127961987 127976741 127977121 128011560 128014201 128016518

PTET:

122323016(mical3a) 122330750(mical2b) 122332809(mical1) 122343293 122348596(mical2a)

LROH:

127154808(mical1) 127156688(mical2b) 127163903(mical3b) 127168070(mical2a) 127180997(mical3a)

OMC:	131524333(mical3a) 131531941(mical1) 131534938(mical2b) 131543645(mical2a)

PPRM:

120460225(mical2b) 120462996(mical1) 120474291(mical3a) 120476785(mical3b) 120492652(mical2a)

RKG:	130069527(mical3b) 130076247(mical1) 130085265(mical2b) 130094854(mical3a) 130100373(mical2a)

MAMB:

125245110(mical3b) 125247010(mical2b) 125253909(mical3a) 125260083(mical1) 125265779(mical2a)

CIDE:

127500023 127504652 127507335 127510441 127515751

MASI:

127412613 127417058 127418738 127419975 127435298 127435886 127437354 127440450 127456203

TROS:

130545209(mical1) 130548227(mical3b) 130551716(mical2b) 130554990(mical2a) 130562598(mical3a)

TDW:	130409271(mical1) 130413881(mical2b) 130418520(mical2a) 130421382(mical3b) 130435342(mical3a)

MANU:

129419749(mical3a) 129430980(mical1) 129432576(mical3b) 129433434(mical2b) 129450903(mical2a)

IPU:	108264267(mical3a) 108269164(mical2b) 108271050(mical2a) 108276121(mical1) 108279684(mical3b)

IFU:	128606578(mical3a) 128611684(mical2b) 128613866(mical2a) 128619588(mical1) 128623139(mical3b)

PHYP:

113530650 113531879 113534442 113536712 113546575

SMEO:

124385840(mical2b) 124390950(mical2a) 124396235(mical3a) 124398989(mical1) 124401046(mical3b)

TFD:	113636039(mical2b) 113641886(mical1) 113645760(mical3b) 113646713(mical2a) 113652390(mical3a)

TVC:	132851331(mical3a) 132855644(mical2b) 132856386(mical2a) 132858665(mical3b) 132861841(mical1)

AMEX:

103027313 103033073 103035944 103039549 103041185(mical2)

CMAO:

118803226(mical3b) 118806635(mical2b) 118817937(mical3a) 118818826(mical2a) 118822153(mical1)

EEE:	113576304 113579066(mical2) 113582500 113584408 113589628 113589629

CHAR:

105905150(mical3a) 105906362(mical1) 105906548(mical2a) 105910422(mical2b)

TRU:	101067707(mical2) 101068062 101075455 101078087(mical3)

TFS:	130519786 130520993(mical2a) 130530518(mical1) 130536351(mical3a) 130536936(mical2b)

TNG:	GSTEN00005241G001 GSTEN00016838G001 GSTEN00017771G001 GSTEN00035663G001

LCO:	104923864 104930096(mical2) 104934557 104935406 104940257

NCC:	104947440 104962979(mical2) 104963695

TBEN:

117471847(mical2a) 117483563(mical1) 117491373(mical2b) 117491784(mical3a)

CGOB:

115009280 115009542(mical3) 115010592 115027260(mical2)

PGEO:

117443733 117447687(mical2b) 117447881(mical3a) 117449461(mical1) 117467669(mical2a)

GACU:

117532902(mical2b) 117533313(mical2a) 117537116 117537388(mical1) 117550841(mical3a)

EMAC:

134863043(mical2a) 134866876(mical1) 134879534 134880401(mical2b) 134881674(mical3a)

ELY:	117249600 117253746(mical3a) 117255597(mical2a) 117258420(mical1) 117261847(mical2b)

EFO:	125883078 125887082(mical2b) 125888125(mical3a) 125891817(mical1) 125905856(mical2a)

PLEP:

121944379(mical2a) 121946665(mical1) 121949689(mical2b) 121949913(mical3a) 121961649

SLUC:

116038671(mical3a) 116043692(mical1) 116048679(mical2b) 116067719(mical2a)

ECRA:

117944361(mical2a) 117947226(mical1) 117948581(mical3a) 117948584(mical2b)

ESP:	116686714 116688308(mical2) 116692730 116694327

PFLV:

114550471 114553052(mical2) 114558963 114559964 114560232

GAT:	120809051(mical2b) 120809321 120812478 120817926(mical3b) 120829288(mical1) 120831698(mical2a)

PPUG:

119195544(mical3a) 119196034(mical2b) 119210297 119223768(mical1) 119229535(mical2a)

AFB:	129099268(mical2a) 129099737(mical1) 129107688(mical3a) 129107792(mical2b) 129112798

CLUM:

117726540 117732014(mical2b) 117732865(mical3a) 117733090(mical1) 117750323(mical2a)

PSWI:

130192965(mical2a) 130195212(mical2b) 130195945(mical3a) 130199506(mical1)

MSAM:

119884220 119890609(mical2a) 119893282 119894420 119895533 119905126(mical1) 119917843

SCHU:

122871423 122874389(mical3a) 122874552(mical2b) 122876097(mical2a) 122882518(mical1)

CUD:	121505383 121506861 121514570(mical3a) 121515399(mical2b) 121517766(mical1)

ALAT:

119017827(mical2a) 119022329(mical1) 119024271(mical2b) 119024855(mical3a) 119032346

MZE:	101468163 101468834 101479267 101482484(mical2) 101483062(mical3)

ONL:	100692605(mical2) 100695036 100701520 100703176 100709311

OAU:	116309401(mical3a) 116313773(mical3b) 116319135(mical2b) 116320228(mical2a) 116321981(mical1)

OLA:	101158080 101161940 101162445(mical3) 101162914(mical2) 101171492

OML:	112141146(mical2b) 112152148(mical3a) 112155189 112158704(mical1) 112160807(mical2a)

CSAI:

133424009 133443877(mical2b) 133443982(mical3a) 133456660(mical1) 133462051(mical2a)

XMA:	102223100 102226853(mical2) 102228008 102231712 102232140

XCO:	114140356 114142885(mical2) 114156092 114160608 114160769

XHE:	116717436 116718551(mical2) 116730706(mical3) 116734966 116736451

PRET:

103459833 103462477 103466250 103467967 103481203(mical3)

PFOR:

103129565 103138857 103139480(mical2) 103142522 103152499

PLAI:

106947923 106950419 106954104 106954617 106958858

PMEI:

106917099 106918113 106926054 106927665 106928687

GAF:	122821586(mical2a) 122826769 122834946(mical1) 122835001(mical3a) 122835003(mical2b)

PPRL:

129351936 129363126(mical3a) 129364203(mical2a) 129377075(mical1) 129379678(mical2b)

CVG:	107084740(mical3) 107090202(mical2) 107092972 107101150 107103849

CTUL:

119777218(mical1) 119787214(mical3a) 119790614 119792185(mical2a) 119799029(mical2b)

GMU:	124867358(mical2a) 124873768(mical1) 124881960(mical3a) 124883380 124884873(mical2b)

NFU:	107374222 107381406(mical2) 107389084 107389209 107390458 107397376

KMR:	108228914(mical2a) 108229591 108237501(mical3a) 108237661(mical1) 108243470(mical2b)

ALIM:

106523178 106530300 106530301 106531251 106534701 106535855

NWH:	119416172(mical2b) 119416240(mical3a) 119428429

AOCE:

111566215 111568429 111570486 111570864 111575931

MCEP:

125000285 125005632(mical2a) 125014760(mical2b) 125014803(mical3a) 125019903(mical1)

CSEM:

103379765 103380424(mical3) 103382487 103385235 103398410(mical2)

POV:	109636865(mical2) 109639898(mical3) 109640267 109640338 109641646 109645222

SSEN:

122766977(mical3b) 122772082(mical2a) 122775703(mical2b) 122775999(mical3a) 122777163(mical1)

HHIP:

117754926(mical2a) 117757289(mical3b) 117763306(mical3a) 117763753(mical2b) 117764345(mical1)

HSP:	118101956(mical3b) 118106389(mical2a) 118109572(mical3a) 118109893(mical2b) 118110746(mical1)

SMAU:

118301881(mical2a) 118315072(mical3a) 118315972(mical2b) 118316539(mical1)

LCF:	108875448 108879907 108890621(mical2a) 108892103 108895333(mical1) 108902312(mical2b)

SDU:	111222517 111228358 111229482 111234946 111236549(mical2)

SLAL:

111644253 111647664 111653081 111653403 111658348(mical2) 111661808

XGL:	120793122(mical2b) 120793404(mical3a) 120795547(mical2a) 120803748(mical1) 120804093

HCQ:	109512974 109520720 109525935(mical2) 109530374(mical3) 109532568

SSCV:

125967643 125970504 125971324 125989204 125992450

SBIA:

133493219 133497787(mical2a) 133501632(mical3a) 133501783(mical2b) 133505272(mical1)

PEE:	133397471 133399270(mical2a) 133402749(mical3a) 133402980(mical2b) 133411700(mical1)

PTAO:

133468212(mical2a) 133472168 133477074(mical1) 133477612(mical2b) 133478766(mical3a)

BPEC:

110154008 110161532 110169287 110175060(mical3) 110175382(mical2)

MALB:

109961790 109962503 109962892(mical2) 109971000

BSPL:

114851857(mical2a) 114857632(mical2b) 114857663(mical3a) 114858577(mical1) 114862396

SJO:	128353185 128357217(mical1) 128358432(mical3a) 128359489(mical2b) 128363569(mical2a)

SASA:

106561386 106561462 106561477 106562102 106567111 106572625 106573174 106573205 106576093 106587193 106609145

STRU:

115152209 115152261 115165585 115167288 115167933 115180187 115197409 115197473 115198686 115203060

OTW:	112215051 112216307 112216812 112218753 112218807(mical2b) 112221779(mical1) 112249569 112252562 112252603 112263679(mical2a)

OMY:	110490203 110492051 110498015 110498817(mical2b) 110501065 110506499 110523110 110523755 110526379 110532622

OGO:	123994686 124002854(mical3a) 124003378 124014359 124032208 124033779(mical2a) 124034241 124034659 124035756 124046025

ONE:	115102495 115106901 115109580 115109617 115112216 115113638 115132454 115133828 115134075

OKI:	109864354 109867080 109867196 109869171 109887421 109889545 109889585 109895259 109896324 109908262

OKE:	118360706 118362387 118372023 118392775 118393841(mical2a) 118396043(mical2b) 118401019 118401065(mical3a)

SALP:

111951310 111952514 111952935(mical3) 111956125 111962602 111962638 111966756 111969353 111976617 112068647

SNH:	120024955 120031783 120046701 120049864 120053289 120054092(mical3a) 120059155 120061078 120065864(mical2b) 120066430

CCLU:

121532284 121532340(mical2b) 121537960 121543978 121545785 121546615 121556336 121559486 121576922 121576970(mical3a)

ELS:	105013576 105016835(mical2) 105018133 105018257 105020163

SFM:	108923275 108931534 108934626 108935978 108942170

PKI:	111832973 111833245 111834363 111834693 111857398

AANG:

118208582(mical1) 118215474(mical2b) 118218793(mical3a) 118228296(mical2a) 118231531(mical3b)

LOC:	102682516(mical3) 102685438 102698794

PSPA:

121294400 121299647 121300159 121318088(mical3a) 121320007 121329865

ARUT:

117397166 117419817 117431940 117432252 117434979

PSEX:

120525937 120526805 120533808

LCM:	102345089 102360081(MICAL3) 102366021(MICAL2)

CMK:	103175113(mical2a) 103189720 103190352(mical3a)

RTP:	109918782 109935358

CPLA:

122557729 122562959 122563302(mical1)

HOC:	132824465(mical2a) 132825026 132828447(mical1)

LERI:

129705655

PMRN:

116939898 116945575

LRJ:	133350324(MICAL3) 133351535

BFO:

118406631

BBEL:

109463367

CIN:

100175527

SCLV:

120331928

SPU:

582210

APLC:

110989175

SKO:

100378899

DME:	Dmel_CG33208(Mical)

DER:

6552049

DSE:

6607011

DSI:	Dsimw501_GD20744(Dsim_GD20744)

DYA:	Dyak_GE24713

DAN:

6499929

DSR:

110188462

DPE:

6598648

DMN:

108155526

DWI:

6647152

DGR:

6567609

DAZ:

108615232

DNV:

108658541

DHE:

111595671

DVI:

6630093

CCAT:

101461727

BOD:

106615184

BDR:

105225857

RZE:

108372393

AOQ:

129235652

TDA:

119678548

MDE:

101887289

SCAC:

106080531

LCQ:

111690633

LSQ:

119612091

GFS:

119640090

ECOE:

129938805

HIS:

119650882

ACOZ:

120957678

AARA:

120905537

ASTE:

118506709

AAG:

5568484

AALB:

109622444 115260102

CQU:	CpipJ_CPIJ013401 CpipJ_CPIJ013403

CPII:

120426071

CNS:

116343176

BCOO:

119081069

AME:

413310

ACER:

107998540

ALAB:

122710683

ADR:

102679655

AFLR:

100869779

BIM:

100744389

BBIF:

117210322

BVK:

117242074

BVAN:

117159486

BTER:

100650962

BAFF:

126915669

BPYO:

122569298

BPAS:

132916255

FVI:

122533470

CCAL:

108628034

OBB:

114878658

OLG:

117607963

MGEN:

117218581

NMEA:

116433105

CGIG:

122399978

SOC:

105204672

MPHA:

105832633 105837906

AEC:

105145217

ACEP:

105617147

PBAR:

105423576

VEM:

105565851

HST:	105181424 105187813

DQU:

106741595

CFO:

105257878

FEX:

115244410

LHU:

105675006

PGC:

109854698

OBO:

105283811

PCF:

106785377

PFUC:

122524970

VPS:

122631229

VCRB:

124425837

VVE:

124951875

NVI:

100120752

CSOL:

105360342

TPRE:

106657087

MDL:

103579831

CGLO:

123267013

FAS:

105273333

DAM:

107048514

AGIF:

122856900

CCIN:

107274519

TCA:

100141546

DPA:

109542110

CSET:

123312276

AGB:

108917939

LDC:

111505921

NVL:

108557182

APLN:

108735517

PPYR:

116173363 116173364

OTU:

111416895

BMOR:

101742566

BMAN:

114246423

MSEX:

115440545

DPL:	KGM_203372

MCIX:

123668387

PMAC:

106717230

PPOT:

106110241

PXU:

106126107

PRAP:

111003396

ZCE:

119835875

CCRC:

123705053

LSIN:

126978528

HAW:

110382349

HZE:

124644745

TNL:

113503945

SLIU:

111360670

OFU:

114362758

PXY:	105391701 105392405

CCRN:

123296568

API:

100168266

DNX:

107162729

AGS:	114132361 114132377

RMD:

113550115

BTAB:

109029643

DCI:

103513125

CLEC:

106674386

HHAL:

106689369

NLU:

111047126

PHU:	Phum_PHUM131590

FOC:

113215085

TPAL:

117640578

ZNE:

110827699

CSEC:

111868080

BROR:

134538857

FCD:	110843113 110851562

DPX:	DAPPUDRAFT_605

DMK:

116923296

DPZ:	124342234 124344495

PVM:	113802897 113810462

PJA:

122249514

PCHN:

125030332

PMOO:

119572369

HAME:

121867957

PCLA:

123755898

PTRU:

123519450

HAZT:

108667277

EAF:	111696410 111696437 111701615 111702890 111708683

LSM:

121124341

TCF:

131883336

PPOI:

119097135 119108074

DSV:

119464482

RSAN:

119403408

RMP:

119163869

VDE:

111252253

VJA:

111264794

TUT:

107372243

DPTE:

113794869

DFR:

124493261

CSCU:

111623901

PTEP:

107453849

ABRU:

129964304

UDV:

129229339

SDM:

118183661

NAI:	NECAME_14230

BMY:	BM_BM10060(Bm10060)

LOA:	LOAG_18362

TSP:

Tsp_08092

LGI:	LOTGIDRAFT_106467 LOTGIDRAFT_51710

PVUL:

126811481

PCAN:

112565533 112565534

BGT:

106078791

GAE:

121370621

HRF:

124122405

HRJ:

124260930

CRG:

105346067

CVN:

111104401

CANU:

128183102

OED:

125673352

MYI:

110457951

PMAX:

117327417

RPHI:

132759086

OBI:

106870794

OSN:

115220265

LAK:

106178150

SMM:	Smp_130440

SHX:	MS3_00010476(MICAL3_1)

OVI:	T265_04365

EGL:

EGR_02335

NVE:	5504232 5509851

EPA:	110233073 110252769

ATEN:

116293795 116294133

ADF:

107332908

AMIL:

114961133 114968231

PDAM:

113668834 113676994

SPIS:

111321254 111326638

DGT:	114530260 114531751

XEN:	124438597 124439271

HMG:	100203435 101241235

HSY:

130654219

TAD:	TRIADDRAFT_451

AQU:	100633984 100634111 105311991

SMIN:

v1.2.023094.t1(symbB.v1.2.023094.t1) v1.2.027574.t1(symbB.v1.2.027574.t1)

PIF:	PITG_13712 PITG_13713 PITG_14532 PITG_14547

PSOJ:

PHYSODRAFT_253756 PHYSODRAFT_324211 PHYSODRAFT_545333 PHYSODRAFT_546706

EHX:	EMIHUDRAFT_465693

» show all

Reference

1 [PMID:20148037]

Authors

Hung RJ, Yazdani U, Yoon J, Wu H, Yang T, Gupta N, Huang Z, van Berkel WJ, Terman JR

Title

Mical links semaphorins to F-actin disassembly.

Journal

Nature 463:823-7 (2010)
DOI:10.1038/nature08724

Sequence

[dme:Dmel_CG33208]

Reference

2 [PMID:22116028]

Authors

Hung RJ, Pak CW, Terman JR

Title

Direct redox regulation of F-actin assembly and disassembly by Mical.

Journal

Science 334:1710-3 (2011)
DOI:10.1126/science.1211956

Sequence

[dme:Dmel_CG33208]

Reference

3 [PMID:24212093]

Authors

Hung RJ, Spaeth CS, Yesilyurt HG, Terman JR

Title

SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics.

Journal

Nat Cell Biol 15:1445-54 (2013)
DOI:10.1038/ncb2871

Sequence

[dme:Dmel_CG33208]

Reference

4 [PMID:21864500]

Authors

Zucchini D, Caprini G, Pasterkamp RJ, Tedeschi G, Vanoni MA

Title

Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1.

Journal

Arch Biochem Biophys 515:1-13 (2011)
DOI:10.1016/j.abb.2011.08.004

Sequence

[hsa:64780]

Reference

5 [PMID:26845023]

Authors

Vitali T, Maffioli E, Tedeschi G, Vanoni MA

Title

Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains.

Journal

Arch Biochem Biophys 593:24-37 (2016)
DOI:10.1016/j.abb.2016.01.016

Sequence

[hsa:64780]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.225

IUBMB Enzyme Nomenclature:

1.14.13.225

ExPASy - ENZYME nomenclature database:

1.14.13.225

BRENDA, the Enzyme Database:

1.14.13.225

DBGET integrated database retrieval system