KEGG ENZYME: 1.14.13.227

ENZYME: 1.14.13.227

Entry

EC 1.14.13.227              Enzyme

Name

propane 2-monooxygenase;
prmABCD (gene names)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

propane,NADH:oxygen oxidoreductase (2-hydroxylating)

Reaction(IUBMB)

propane + NADH + H+ + O2 = propan-2-ol + NAD+ + H2O [RN:R10702]

Reaction(KEGG)

R10702

Substrate

propane [CPD:C20783];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

propan-2-ol [CPD:C01845];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Comment

The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.

History

EC 1.14.13.227 created 2016

Pathway

ec00650

Butanoate metabolism

ec01100

Metabolic pathways

Orthology

K18223

propane 2-monooxygenase large subunit

K18224

propane 2-monooxygenase small subunit

Genes

GAI:	IMCC3135_23930(mmoY) IMCC3135_23940(mmoX)

BCAI:

K788_0003073 K788_0003075

PHS:	C2L64_20505 C2L64_20515

PACP:

FAZ97_27890 FAZ97_27900

CABA:

SBC2_62630(prmA_2) SBC2_62650(prmC_2)

VEI:	Veis_4409 Veis_4411

MPT:	Mpe_A0950(prmA) Mpe_A0952(ormC)

METP:

C1M51_04490 C1M51_04500

XYK:	GT347_05725 GT347_05735

AZO:	azo1219 azo1221

AOA:	dqs_1334 dqs_1336

AZR:	CJ010_07485 CJ010_07495

MAMO:

A6B35_24800 A6B35_24810

MESM:

EJ066_17145 EJ066_17155

MOH:	IHQ72_18715 IHQ72_18725

MMEI:

LRP31_28255 LRP31_28265

AAK:	AA2016_6220 AA2016_6223

RJG:	CCGE525_05445 CCGE525_05455

BJA:	blr3677(blr3677) blr3679(blr3679)

BJU:	BJ6T_61670 BJ6T_61690

BJP:	RN69_29860 RN69_29870

BRA:	BRADO4348 BRADO4350

BBT:	BBta_3630 BBta_3632

AOL:	S58_14660 S58_14680

BIC:	LMTR13_17510 LMTR13_17520

BOT:	CIT37_20150 CIT37_20160

BSEP:

HAP48_0008250 HAP48_0008260

BQB:	J4P68_0027300 J4P68_0027310

BBAN:

J4G43_042520 J4G43_042530

BGK:	IC762_13930 IC762_13940

BPAH:

QA639_17710 QA639_17720

BXN:	I3J27_35020 I3J27_35030

STAR:

G3545_26545 G3545_26555

LNE:	FZC33_06715 FZC33_06725

BID:	Bind_3395 Bind_3397

MSL:	Msil_1649 Msil_1651

MTUN:

MTUNDRAET4_0144.1(prmC) MTUNDRAET4_0146.1(prmA)

PLEO:

OHA_1_03553(mmoY) OHA_1_03555(mmoX)

HDI:	HDIA_3874(mmoY) HDIA_3876(mmoX)

JIE:	OH818_18920

PGD:	Gal_01406 Gal_01408

MALG:

MALG_01260 MALG_01262

PABY:

Ga0080574_TMP3298 Ga0080574_TMP3300

AHT:	ANTHELSMS3_04149(mmoY) ANTHELSMS3_04151(mmoX)

MALU:

KU6B_14980 KU6B_15000

PALX:

GQA70_22650 GQA70_22660

RSP:	RSP_2792 RSP_2794

RSH:	Rsph17029_1506 Rsph17029_1508

RSK:	RSKD131_1174 RSKD131_1176

PAMI:

JCM7686_pAMI4p208 JCM7686_pAMI4p211

GFU:	KM031_18825 KM031_18835

ACR:	Acry_1379 Acry_1381

AMV:	ACMV_14260(prmC) ACMV_14280(prmA)

AZL:	AZL_c02870 AZL_c02890

ALI:	AZOLI_p10730(prmC) AZOLI_p10732(prmA)

ATI:	AL072_26915 AL072_26925

AZZ:	DEW08_25720 DEW08_25730

AOZ:	HUE56_03135 HUE56_03145

AZS:	E6C72_23970 E6C72_23980

SKT:	IGS68_06155 IGS68_06165

SMUC:

JL100_021455 JL100_021465 JL100_032495 JL100_032505

SROE:

JL101_020155 JL101_020165

BTS:	Btus_1550 Btus_1552 Btus_2036

PANC:

E2636_01275 E2636_01285

SAY:	TPY_3182 TPY_3184

SAP:	Sulac_1731 Sulac_1734

MSA:	Mycsm_01477 Mycsm_01479

MPSE:

MPSD_01250

MSHO:

MSHO_12020

MDX:	BTO20_38070

MSIM:

MSIM_49440 MSIM_49470

MSM:	MSMEG_1971

MSG:	MSMEI_1927 MSMEI_1929

MSB:	LJ00_09835 LJ00_09845

MSN:	LI99_09835 LI99_09845

MSH:	LI98_09835 LI98_09845

MCB:	Mycch_5463 Mycch_5465

MLL:	B1R94_07255 B1R94_07265

MMAG:

MMAD_31800

MTY:	MTOK_17290 MTOK_17310

MHEV:

MHEL_18730

MGO:	AFA91_29110 AFA91_29120

MCRO:

MI149_22725

MTER:

4434518_02253(mmoX) 4434518_02255(mmoY)

MHIB:

MHIB_39860 MHIB_39880

ASD:	AS9A_2157 AS9A_2159

NFR:	ERS450000_02058(mmoY) ERS450000_02060(mmoX)

RHA:	RHA1_ro00441 RHA1_ro00443

ROA:	Pd630_LPD04550 Pd630_LPD04552

RAV:	AAT18_26335 AAT18_26345

RFA:	A3L23_02106(mmoY) A3L23_02108(mmoX)

RHS:	A3Q41_01275(mmoX) A3Q41_01277(mmoY)

RHW:	BFN03_06840 BFN03_06850

RRZ:	CS378_15775 CS378_15785

RHOD:

AOT96_22160 AOT96_22170

RCR:	NCTC10994_02802(mmoX) NCTC10994_02804(mmoY)

RKO:	JWS14_19305 JWS14_19315

ROZ:	CBI38_04455 CBI38_04465

RPSK:

JWS13_25460 JWS13_25470

GBR:	Gbro_3551 Gbro_3553

GPO:	GPOL_c34280 GPOL_c34300

GOR:	KTR9_3575 KTR9_3577

GTA:	BCM27_18320 BCM27_18330

GRU:	GCWB2_18380(mmoX) GCWB2_18390(mmoY)

GOM:	D7316_05134(mmoY) D7316_05136(mmoX)

GAV:	C5O27_09755 C5O27_09765

GOD:	GKZ92_17365 GKZ92_17375

GAM:	GII34_01545 GII34_01555

GJI:	H1R19_17090 H1R19_17100

GAMI:

IHQ52_21135 IHQ52_21145

GMG:	NWF22_02570 NWF22_02580

SSPN:

LXH13_39055 LXH13_39065

ARTY:

AHiyo4_21320 AHiyo4_21340

NDK:	I601_2091(mmoX) I601_2093(mmoY)

NPS:	KRR39_09015 KRR39_09025

KQI:	F1D05_01950 F1D05_01960

KSL:	OG809_21805 OG809_21815 OG809_39430 OG809_39440

FRA:	Francci3_2518 Francci3_2520

NAKA:

H7F38_07135 H7F38_07145

SACG:

FDZ84_37200 FDZ84_37210

AMD:	AMED_4324 AMED_4326

AMN:	RAM_22015 RAM_22025

AMM:	AMES_4272 AMES_4274

AMZ:	B737_4272 B737_4274

AMQ:	AMETH_2368 AMETH_2370 AMETH_4324 AMETH_4326

AMYB:

BKN51_07845 BKN51_07855

AACD:

LWP59_05735 LWP59_05745 LWP59_20300 LWP59_20310

APRT:

MUY14_15865 MUY14_15875

ARHD:

VSH64_06515 VSH64_06525 VSH64_14835 VSH64_14845

PDX:	Psed_0629 Psed_0631

PSEA:

WY02_19390 WY02_19400

PSEE:

FRP1_23450 FRP1_23460

PSEH:

XF36_22070 XF36_22080

PSEQ:

AD006_02645 AD006_02655

PECQ:

AD017_10460 AD017_10470

PHH:	AFB00_07920 AFB00_07930

PAUT:

Pdca_07470 Pdca_07490

PBRO:

HOP40_04720 HOP40_04730

PPEL:

H6H00_05165 H6H00_05175

KUT:	JJ691_42080 JJ691_42100

ACTY:

OG774_23125 OG774_23135

RUB:	GBA63_12420 GBA63_12430

BALA:

DSM104299_05052(prmC_2) DSM104299_05054(prmA)

PARN:

NBH00_09495 NBH00_09500 NBH00_21780 NBH00_21790

» show all

Reference

1 [PMID:14645271]

Authors

Kotani T, Yamamoto T, Yurimoto H, Sakai Y, Kato N

Title

Propane monooxygenase and NAD+-dependent secondary alcohol dehydrogenase in propane metabolism by Gordonia sp. strain TY-5.

Journal

J Bacteriol 185:7120-8 (2003)
DOI:10.1128/JB.185.24.7120-7128.2003

Reference

2 [PMID:17873074]

Authors

Sharp JO, Sales CM, LeBlanc JC, Liu J, Wood TK, Eltis LD, Mohn WW, Alvarez-Cohen L

Title

An inducible propane monooxygenase is responsible for N-nitrosodimethylamine degradation by Rhodococcus sp. strain RHA1.

Journal

Appl Environ Microbiol 73:6930-8 (2007)
DOI:10.1128/AEM.01697-07

Reference

3 [PMID:21183637]

Authors

Furuya T, Hirose S, Osanai H, Semba H, Kino K

Title

Identification of the monooxygenase gene clusters responsible for the regioselective oxidation of phenol to hydroquinone in mycobacteria.

Journal

Appl Environ Microbiol 77:1214-20 (2011)
DOI:10.1128/AEM.02316-10

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.227

IUBMB Enzyme Nomenclature:

1.14.13.227

ExPASy - ENZYME nomenclature database:

1.14.13.227

BRENDA, the Enzyme Database:

1.14.13.227

DBGET integrated database retrieval system