Entry
Name
3-hydroxybenzoate 4-monooxygenase;
3-hydroxybenzoate 4-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
3-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O [RN:
R01628 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.
History
EC 1.14.13.23 created 1972 as EC 1.14.99.13, transferred 1984 to EC 1.14.13.23
Pathway
ec00624 Polycyclic aromatic hydrocarbon degradation
ec01120 Microbial metabolism in diverse environments
Orthology
K19065 3-hydroxybenzoate 4-monooxygenase
Genes
Taxonomy
Reference
Authors
Michalover JL, Ribbons DW, Hughes H.
Title
3-Hydroxybenzoate 4-hydroxylase from Pseudomonas testosteroni.
Journal
Reference
Authors
Premkumar R, Rao PV, Sreeleela NS, Vaidyanathan CS.
Title
m-Hydroxybenzoic acid 4-hydroxylase from Aspergillus niger.
Journal
Other DBs
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.23