Entry
Name
L-lysine N6-monooxygenase (NADPH);
lysine N6-hydroxylase;
L-lysine 6-monooxygenase (NADPH) (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
L-lysine + NADPH + H+ + O2 = N6-hydroxy-L-lysine + NADP+ + H2O [RN:
R00448 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein (FAD). The enzyme from strain EN 222 of Escherichia coli is highly specific for L-lysine; L-ornithine and L-homolysine are, for example, not substrates.
History
EC 1.14.13.59 created 1999, modified 2001, modified 2012
Pathway
ec00997 Biosynthesis of various other secondary metabolites
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
Genes
ECOO : ECRM13514_1293(iucD)
ECOH : ECRM13516_1249(iucD)
ECV : APECO1_O1CoBM169(iucD)
CLAP : NCTC11466_02784(iucD)
YPE : YPO0993(iucD) YPO1530(alcA)
YPK : y2640(ysuI) y3384(iucD)
YPM : YP_1419(alcA) YP_3447(iucD)
YPP : YPDSF_0525 YPDSF_1446
YPZ : YPZ3_0745(iucD) YPZ3_1395(alcA)
YPT : A1122_00010 A1122_18255
YPD : YPD4_0700(iucD) YPD4_1361(alcA)
YPX : YPD8_0700(iucD) YPD8_1587(alcA)
YPW : CH59_308 CH59_870(iucD)
YPJ : CH55_1008 CH55_3547(iucD)
YPV : BZ15_2022 BZ15_2580(iucD)
YPL : CH46_3596 CH46_4152(iucD)
YPS : YPTB1542(alcA) YPTB3266(iucD)
YPO : BZ17_3344(iucD) BZ17_973
YPI : YpsIP31758_0711(iucD) YpsIP31758_2447
YPQ : DJ40_3171(iucD) DJ40_670
YPU : BZ21_2546(iucD) BZ21_880
YPR : BZ20_2848(iucD) BZ20_422
YPC : BZ23_1159 BZ23_2827(iucD)
YSI : BF17_03350 BF17_17060
SMAR : SM39_3651 SM39_4454(iucD)
SMAC : SMDB11_3458 SMDB11_4148(iucD)
SPE : Spro_0025 Spro_0919 Spro_2520
SRR : SerAS9_0844 SerAS9_2495
SRL : SOD_c07750(iucD1) SOD_c23600(iucD2) SOD_c47380(iucD)
SRY : M621_04275 M621_12890 M621_25650
SPLY : Q5A_004125(iucD_1) Q5A_013040(iucD_2)
SRS : SerAS12_0844 SerAS12_2496
SRA : SerAS13_0844 SerAS13_2497
SLQ : M495_03880 M495_12465 M495_24705
SERS : SERRSCBI_00130 SERRSCBI_20200
SQU : E4343_03620 E4343_11905 E4343_16150
SFJ : SAMEA4384070_0951(iucD)
SOF : NCTC11214_00581(iucD)
SENP : KHA73_04105 KHA73_23070
RAH : Rahaq_1994 Rahaq_3478
RACE : JHW33_06790 JHW33_11610
RAQ : Rahaq2_2139 Rahaq2_3554
ROX : BV494_04390 BV494_12445
RVC : J9880_03080 J9880_19430
RIU : I2123_11510 I2123_19285
EAME : GXP68_03935 GXP68_09665
RBAD : H2866_01225 H2866_12030
ETO : RIN69_13275 RIN69_18765
PAM : PANA_0353(iucD) PANA_0636(alcA)
PLF : PANA5342_3679 PANA5342_4061(iucD)
PAJ : PAJ_3508(iucD) PAJ_3771(alcA)
PAQ : PAGR_g3562 PAGR_g3924
PVA : Pvag_pPag30340(dfoA)
VAU : VANGNB10_67p040c(angU)
VSA : VSAL_I0135(iucD) VSAL_II0278(iucD)
PSYC : DABAL43B_1549(rhbE)
ACB : A1S_1648 A1S_2384 A1S_2572
ABC : ACICU_01673 ACICU_02580(basC)
ABB : ABBFA_01045(iucD_1) ABBFA_01827(iucD_2)
ABZ : ABZJ_01834 ABZJ_02774(basC)
ABR : ABTJ_01133 ABTJ_02034
ABD : ABTW07_1889 ABTW07_2829(basC)
ABAD : ABD1_16330 ABD1_23780(basC)
ABJ : BJAB07104_02079 BJAB07104_02738
ABAB : BJAB0715_01856 BJAB0715_02786
ABAJ : BJAB0868_01795 BJAB0868_02620
ABAZ : P795_5010 P795_9045
ABK : LX00_08310 LX00_13130
ABAU : IX87_08665 IX87_19060
ABAA : IX88_10145 IX88_15210
ABW : BL01_04715 BL01_08525
ABAL : ABLAC_10780 ABLAC_24790
ALC : OTEC02_05360 OTEC02_07335
APRL : PY247_17250 PY247_23365(acbB)
SCAA : TUM17387_16290(pubA)
LCJ : NCTC11976_01019(iucD)
MISZ : MishRS11D_43100(iucD)
FGU : SD28_01870 SD28_04605
KUS : B9G99_08695 B9G99_09250
NANI : NCTC12227_01601(iucD_1)
CRZ : D1345_00070(basC) D1345_06150
CHAE : CH06BL_00120(basC) CH06BL_13350
AXX : ERS451415_02967(iucD)
AMIM : MIM_c25820(alcA1) MIM_c25860(alcA2)
OUR : CEQ07_01965 CEQ07_03555
ALF : CFBP5473_16835(basC)
REC : RHECIAT_PC0000681(vbsO)
REL : REMIM1_PF00420(iucD)
REP : IE4803_PC00508(iucD)
REI : IE4771_PD00518(iucD)
RHN : AMJ98_PC00365 AMJ98_PE00534(iucD)
RPHA : AMC79_PC00336 AMC79_PD00672(iucD)
RHX : AMK02_PC00354 AMK02_PD00403(iucD)
RHK : Kim5_PA00462 Kim5_PC00465(iucD)
REZ : AMJ99_PB00359 AMJ99_PD00534(iucD)
BAO : BAMF_1075(RBAM_010080)
BSON : S101395_03652(iucD)
BPUM : BW16_05050 BW16_05860
BPUS : UP12_05010 UP12_05470
BXI : BK049_02790 BK049_03280
BALT : CFN77_04950 CFN77_05460
BAER : BAE_12510 BAE_13020
BSAF : BSL056_04920 BSL056_05415
BACW : QR42_04850 QR42_05305
BFX : BC359_07740 BC359_19160
HHD : HBHAL_1030 HBHAL_4894
HMN : HM131_01005 HM131_02990 HM131_07085
HLI : HLI_11475 HLI_13455 HLI_20520
HNZ : P9989_00290 P9989_15090
SJE : AAV35_001545 AAV35_013590
GRC : GI584_04190 GI584_16200
POF : GS400_00155 GS400_00165
CRL : NCTC7448_00161(iucD)
NSL : BOX37_17000 BOX37_20165
NAH : F5544_07265 F5544_31155
SCO : SCO2016(SC7H2.30c) SCO2783(SCC105.14)
SGR : SGR_1210 SGR_4749(alcA) SGR_5513
SGB : WQO_07760 WQO_11790 WQO_29280
SFI : SFUL_1562 SFUL_2378 SFUL_6271
SANL : KZO11_07490 KZO11_11985 KZO11_31345 KZO11_35730
SGRF : SGFS_066720 SGFS_073930 SGFS_086000
SCYE : R2B67_04680 R2B67_23975 R2B67_28555
SCB : SCAB_57941(desB) SCAB_68811
SVL : Strvi_1068 Strvi_7089
SHO : SHJGH_3255 SHJGH_4049
SRC : M271_20110 M271_36335
SMAL : SMALA_1944 SMALA_4656
SSOI : I1A49_12875 I1A49_27350
SDV : BN159_5487(alcA) BN159_6449
STRP : F750_1862 F750_2609(desB)
SCI : B446_10515 B446_14680 B446_31510
SLV : SLIV_23760(alcA) SLIV_27630
SGU : SGLAU_09125 SGLAU_12695(alcA)
SVT : SVTN_09680 SVTN_13765
STRE : GZL_06515 GZL_06724 GZL_09053
SCW : TU94_08665 TU94_12175
SLD : T261_6168 T261_6371 T261_7621
SLC : SL103_05005 SL103_09250 SL103_10275
SXI : SXIM_06680 SXIM_09420
STRM : M444_10200 M444_13350
STRC : AA958_06030 AA958_10365
SAMB : SAM23877_2102(rhbE) SAM23877_2818(desB)
SPRI : SPRI_4759 SPRI_5512
SCZ : ABE83_04985 ABE83_24055 ABE83_28035
SCX : AS200_28450 AS200_32920
SRW : TUE45_02530(iucD_1) TUE45_03398(iucD_2)
SLE : sle_44570(desB) sle_51230(sle_51230)
SRN : A4G23_01835(iucD_1) A4G23_04771(iucD_2)
SPAV : Spa2297_08205 Spa2297_11790
SCLF : BB341_18595 BB341_22060
SGS : AVL59_36990 AVL59_41585
STSI : A4E84_10405 A4E84_14670 A4E84_35470
SKY : D0C37_22570 D0C37_26215
SALW : CP975_08715 CP975_12500
SGM : GCM10017557_52950 GCM10017557_62050
SCAD : DN051_24640 DN051_28385
SLS : SLINC_2333 SLINC_3206
SNR : SNOUR_30320 SNOUR_31330(alcA) SNOUR_40995
SALU : DC74_2285 DC74_2484
SALL : SAZ_12110 SAZ_13765
SPLU : LK06_006925 LK06_010725
STRD : NI25_24940 NI25_29085
SNW : BBN63_16005 BBN63_26555
SAUO : BV401_13200 BV401_27140
SVU : B1H20_06865 B1H20_11035 B1H20_30145
SPUN : BFF78_26570 BFF78_29745 BFF78_31120
SGV : B1H19_09125 B1H19_11005 B1H19_11955
SALF : SMD44_02199(iucD) SMD44_03081(iucD)
SLX : SLAV_23920(iucD1) SLAV_27510(iucD2) SLAV_39955(iucD3)
STRO : STRMOE7_09830 STRMOE7_14925
SNZ : DC008_08395 DC008_12275
SGE : DWG14_05325(iucD_1) DWG14_06029(iucD_2) DWG14_06338(iucD_3)
SLK : SLUN_09760 SLUN_14255
SDX : C4B68_25735 C4B68_30185
SQZ : FQU76_06620 FQU76_10310 FQU76_11675
SCYA : EJ357_11795 EJ357_16805
SAST : CD934_21330 CD934_25455
SNQ : CP978_09735 CP978_12910
STIR : DDW44_03260 DDW44_09000
SKA : CP970_27935 CP970_32695
SGZ : C0216_23090 C0216_26190
SVN : CP980_21555 CP980_24915
SHAW : CEB94_10875 CEB94_15260
SFIC : EIZ62_06225 EIZ62_21540 EIZ62_25125
SGAL : CP966_08865 CP966_13290
SSPO : DDQ41_02630 DDQ41_07470
SVR : CP971_10620 CP971_29835
SPAD : DVK44_05965 DVK44_10040 DVK44_14940
SFY : GFH48_25695 GFH48_29955
SAQU : EJC51_13565 EJC51_19205
SGF : HEP81_05013 HEP81_05771
SCAV : CVT27_06620 CVT27_10480 CVT27_28775
SSEO : D0Z67_06905 D0Z67_10260
SRIM : CP984_30950 CP984_32055
SPHV : F9278_10310 F9278_16755
SCIN : CP977_08980 CP977_12445
SFUG : CNQ36_08915 CNQ36_12660
SPAC : B1H29_23530 B1H29_27290
STSU : B7R87_06610 B7R87_10040 B7R87_11320 B7R87_30270
SCHA : CP983_27385 CP983_32310
SGX : H4W23_10130 H4W23_14865
SCOE : CP976_11640 CP976_16215
SBAT : G4Z16_26680 G4Z16_27585
SSPB : CP982_11830 CP982_16540
SNF : JYK04_02653(iucD_1) JYK04_03396(iucD_2)
SPLA : CP981_08910 CP981_09920
SBRO : GQF42_12985 GQF42_17600
STUI : GCM10017668_16470 GCM10017668_25040
SATA : C5746_10955 C5746_15065
SCHF : IPT68_09420 IPT68_13605
SHUN : DWB77_04909(iucD_1) DWB77_05729(iucD_2)
SHAR : HUT13_03955 HUT13_05340
SCYG : S1361_11075(iucD1) S1361_15230(iucD2)
SFEU : IM697_07205 IM697_11900
SLIA : HA039_16385 HA039_26020
SDW : K7C20_08415 K7C20_09455
SVD : CP969_11170 CP969_15025
SCAL : I6J39_07060 I6J39_11250 I6J39_29950 I6J39_34655
SAUH : SU9_006880 SU9_007900
SFB : CP974_10280 CP974_25540
SROI : IAG44_26040 IAG44_30135
SXN : IAG42_22695 IAG42_26765
SGJ : IAG43_07425 IAG43_11120 IAG43_25475
SANU : K7396_26925 K7396_27865
STRY : EQG64_10905 EQG64_30040
SDD : D9753_22555 D9753_26590
SACT : DMT42_09505 DMT42_14660
SINE : KI385_07805 KI385_11505 KI385_12605
SLF : JEQ17_29660 JEQ17_34490
SDEC : L3078_11875 L3078_16875
SDUR : M4V62_26975 M4V62_31115
SYAN : NRK68_08960 NRK68_12360
SRUG : F0345_05775 F0345_08965
SAKB : K1J60_28015 K1J60_33650
STAA : LDH80_25480 LDH80_29265
SNIG : HEK616_14980 HEK616_17010
SVIO : HWN34_21170 HWN34_24580
SCAE : IHE65_28450 IHE65_33780
STUB : MMF93_06945 MMF93_07890
SSPN : LXH13_10555 LXH13_15505
SCIR : STRCI_002201 STRCI_003147
SXT : KPP03845_102219(iucD)
SLON : LGI35_13785 LGI35_17875
STUD : STRTU_005412 STRTU_005604
SGK : PET44_08820 PET44_12045
SANT : QR300_17975 QR300_31905
SYUN : MOV08_30340 MOV08_31340 MOV08_35465 MOV08_42040
SARG : HKX69_21850 HKX69_25890
SJN : RI060_04845 RI060_26945 RI060_31965
SCYN : N8I84_11210 N8I84_15345
SFIY : F0344_23435 F0344_28395
SHAU : K9S39_09315 K9S39_10135 K9S39_33045 K9S39_34020
SKG : KJK29_24100 KJK29_28910
SCOA : QU709_27135 QU709_32790
SROC : RGF97_21605 RGF97_26075 RGF97_31030
SFP : QUY26_25425 QUY26_30150
SCHG : NRO40_06730 NRO40_10265 NRO40_24140
STTN : BSL84_08655 BSL84_11945
SINN : ABB07_24140 ABB07_28300
SCT : SCAT_1143 SCAT_p1224(alcA)
SCY : SCATT_11400 SCATT_p05040
KAB : B7C62_06735 B7C62_10675 B7C62_31400
ARTY : AHiyo4_04000 AHiyo4_04010
NAQU : ENKNEFLB_01322(iucD)
KQI : F1D05_35110 F1D05_36505
FRA : Francci3_3275 Francci3_4057
FSY : FsymDg_0710 FsymDg_2883
KBU : Q4V64_12630 Q4V64_18445 Q4V64_41730
SAQ : Sare_0571 Sare_1046 Sare_2739
MAU : Micau_2597 Micau_3806
MICB : MicB006_2754 MicB006_2881
MTUA : CSH63_06350 CSH63_12080
MCHL : PVK74_08710 PVK74_09360
MPRN : Q3V37_03980 Q3V37_23420
DVC : Dvina_35560 Dvina_39455 Dvina_40770
DMAT : Dmats_30405 Dmats_34360 Dmats_35660
CAI : Caci_1810 Caci_4294 Caci_6320
NIA : A8C56_02590 A8C56_12455
ATEE : K9M52_01450 K9M52_12065
FLW : LVD16_14410 LVD16_17540
KAN : IMCC3317_12960(iucD)
CGLE : NCTC11432_00673(iucD)
CRHI : KB553_09350 KB553_19535
CHRJ : CHRYMOREF3P_0463(alcA)
» show all
Taxonomy
Reference
Authors
Plattner HJ, Pfefferle P, Romaguera A, Waschutza S, Diekmann H.
Title
Isolation and some properties of lysine N6-hydroxylase from Escherichia coli strain EN222.
Journal
Reference
Authors
Macheroux P, Plattner HJ, Romaguera A, Diekmann H.
Title
FAD and substrate analogs as probes for lysine N6-hydroxylase from Escherichia coli EN 222.
Journal
Reference
Authors
Thariath AM, Fatum KL, Valvano MA, Viswanatha T.
Title
Physico-chemical characterization of a recombinant cytoplasmic form of lysine: N6-hydroxylase.
Journal
Reference
Authors
de Lorenzo V, Bindereif A, Paw BH, Neilands JB
Title
Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12.
Journal
Sequence
Reference
5
Authors
Marrone, L., Siemann, S., Beecroft, M. and Viswanatha, T.
Title
Specificity of lysine:N-6-hydroxylase: A hypothesis for a reactive substrate intermediate in the catalytic mechanism.
Journal
Bioorg Chem 24:401-406 (1996)
Reference
Authors
Goh CJ, Szczepan EW, Menhart N, Viswanatha T.
Title
Studies on lysine:N6-hydroxylation by cell-free systems of Aerobacter aerogenes 62-1.
Journal
Other DBs