KEGG   ENZYME: 1.14.13.61
Entry
EC 1.14.13.61               Enzyme                                 
Name
2-hydroxyquinoline 8-monooxygenase;
2-oxo-1,2-dihydroquinoline 8-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating)
Reaction(IUBMB)
quinolin-2-ol + NADH + H+ + O2 = quinolin-2,8-diol + NAD+ + H2O [RN:R05158]
Reaction(KEGG)
R05158
Substrate
quinolin-2-ol [CPD:C06338];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
quinolin-2,8-diol [CPD:C06342];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
Requires iron. Quinolin-2-ol exists largely as the quinolin-2(1H)-one tautomer.
History
EC 1.14.13.61 created 1999
Reference
1  [PMID:7629085]
  Authors
Rosche B, Tshisuaka B, Fetzner S, Lingens F.
  Title
2-Oxo-1,2-dihydroquinoline 8-monooxygenase, a two-component enzyme system from Pseudomonas putida 86.
  Journal
J Biol Chem 270:17836-42 (1995)
DOI:10.1074/jbc.270.30.17836
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.61
IUBMB Enzyme Nomenclature: 1.14.13.61
ExPASy - ENZYME nomenclature database: 1.14.13.61
BRENDA, the Enzyme Database: 1.14.13.61
CAS: 166799-89-9

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Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (19)   
   UniProt (1)   
   PDBSTR (18)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
3D Structure (3)   
   PDB (3)   
All databases (35)   

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