Entry Name 3-hydroxyindolin-2-one monooxygenase;
Class Oxidoreductases;BRITE hierarchy
Sysname 3-hydroxyindolin-2-one,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming)
Reaction(IUBMB) 3-hydroxyindolin-2-one + [reduced NADPH---hemoprotein reductase] + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R07422 ]
Reaction(KEGG) Substrate 3-hydroxyindolin-2-one [CPD:
C11130 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one [oxidized NADPH---hemoprotein reductase];
H2O [CPD:
C00001 ]
Comment A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).
History EC 1.14.14.109 created 2012 as EC 1.14.13.139, transferred 2018 to EC 1.14.14.109
Pathway ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
Orthology K13225 3-hydroxyindolin-2-one monooxygenase
Genes TAES : 123101969 123110086 123119085
Taxonomy Reference Authors Glawischnig E, Grun S, Frey M, Gierl A
Title Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses.
Journal Reference Authors Frey M, Chomet P, Glawischnig E, Stettner C, Grun S, Winklmair A, Eisenreich W, Bacher A, Meeley RB, Briggs SP, Simcox K, Gierl A.
Title Analysis of a chemical plant defense mechanism in grasses.
Journal Sequence Reference Authors Spiteller P, Glawischnig E, Gierl A, Steglich W
Title Studies on the biosynthesis of 2-hydroxy-1,4-benzoxazin-3-one (HBOA) from 3-hydroxyindolin-2-one in Zea mays.
Journal Sequence Other DBs
