KEGG   ENZYME: 1.14.14.113
Entry
EC 1.14.14.113              Enzyme                                 
Name
alpha-humulene 10-hydroxylase;
CYP71BA1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
alpha-humulene,[reduced NADPH---hemoprotein reductase]:oxygen 10-oxidoreductase
Reaction(IUBMB)
alpha-humulene + O2 + [reduced NADPH---hemoprotein reductase] = 10-hydroxy-alpha-humulene + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R09934]
Reaction(KEGG)
R09934
Substrate
alpha-humulene [CPD:C09684];
O2 [CPD:C00007];
[reduced NADPH---hemoprotein reductase] [CPD:C03024]
Product
10-hydroxy-alpha-humulene [CPD:C20229];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The recommended numbering of humulene gives 10-hydroxy-alpha-humulene as the product rather than 8-hydroxy-alpha-humulene as used by the reference. See {iupac/sectionF/index::Section F: Natural Product Nomenclature}.
History
EC 1.14.14.113 created 2012 as EC 1.14.13.150, transferred 2018 to EC 1.14.14.113
Orthology
K21717  alpha-humulene 10-hydroxylase
Reference
1  [PMID:20730551]
  Authors
Yu F, Okamoto S, Harada H, Yamasaki K, Misawa N, Utsumi R
  Title
Zingiber zerumbet CYP71BA1 catalyzes the conversion of alpha-humulene to 8-hydroxy-alpha-humulene in zerumbone biosynthesis.
  Journal
Cell Mol Life Sci 68:1033-40 (2011)
DOI:10.1007/s00018-010-0506-4
  Sequence
[ag:BAJ39893]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.113
IUBMB Enzyme Nomenclature: 1.14.14.113
ExPASy - ENZYME nomenclature database: 1.14.14.113
BRENDA, the Enzyme Database: 1.14.14.113

  All links  
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (4)   
   UniProt (3)   
   SWISS-PROT (1)   
Protein domain (5)   
   InterPro (5)   
All databases (19)   

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