Entry
Name
methyl farnesoate epoxidase;
CYP15A1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R08148 ]
Reaction(KEGG)
Substrate
methyl (2E,6E)-farnesoate [CPD:
C16503 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
juvenile hormone III [CPD:
C09694 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC
1.14.14.128 , farnesoate epoxidase) [1,2].
History
EC 1.14.14.127 created 2015 as EC 1.14.13.202, transferred 2018 to EC 1.14.14.127
Pathway
ec00981 Insect hormone biosynthesis
Orthology
K14937 methyl farnesoate epoxidase / farnesoate epoxidase
Genes
ASTE : 118512764 118516377
AALB : 109400580 109404918
BCOO : 119066619 119073268 119073855 119083868
ACER : 107999236 107999579
ALAB : 122719253 122721167
AFLR : 100866566 100870838
CCAL : 108622763 108626525 108628064
MGEN : 117222866 117228940
NMEA : 116430512 116432333
CGIG : 122395104 122402997
ACEP : 105617514 105626825
PBAR : 105428423 105432897
PFUC : 122515519 122517103
VCRB : 124424609 124428312
CSOL : 105360112 105365111
TPRE : 106655022 106660328
CGLO : 123266720 123266763 123271251
AGIF : 122855280 122856814
CINS : 118068554 118074777
VCAN : 122405938 122417189
CCIN : 107269292 107273413
AROA : 105684963 105685744
API : 100160402 100162751 100169165
HVI : 124354873 124354874 124354875 124354880 124355845 124363098
MQU : 128994102 128995641 129004845 129004882
FOC : 113202002 113205309 113218014
TPAL : 117642593 117653881
CSEC : 111866554 111868805 111871464 111871465
SGRE : 126267564 126272610 126272979 126272980 126273242
BROR : 134527535 134528134 134536071 134538589 134538919 134541542 134541570
IEL : 124159398 124161931 124162168 124162206 124162214 124162282 124162320 124162352 124162462 124162472 124162501 124162633 124162844 124166645 124167510 124167769 124167830 124168163
DPX : DAPPUDRAFT_301663 DAPPUDRAFT_315215
DMK : 116924346 116931639 116932049 116932050 116932816 116932985 116932987 116933272 116933273 116933274 116933275 123476951
DPZ : 124349645 124349655 124349661
PCHN : 125030907 125030911
PCLA : 123751070 123755940 123767222
CQD : 128700072 128700083 128703296 128703656
TCF : 131885335 131888931 131892864
PPOI : 119089751 119091396 119101642 119102852 119104409 119104475 119104495 119104602 119104834 119104835 119104836 119104837 119104838 119104840 119107626 119108650 119109044 119109052 119110551 119110590
» show all
Taxonomy
Reference
Authors
Helvig C, Koener JF, Unnithan GC, Feyereisen R
Title
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata.
Journal
Sequence
Reference
Authors
Daimon T, Shinoda T
Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
Journal
Other DBs