KEGG ENZYME: 1.14.14.153

ENZYME: 1.14.14.153

Entry

EC 1.14.14.153              Enzyme

Name

indole-2-monooxygenase;
BX2 (gene name);
CYP71C4 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

indole,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating)

Reaction(IUBMB)

indole + [reduced NADPH---hemoprotein reductase] + O2 = indolin-2-one + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R07403]

Reaction(KEGG)

R07403

Substrate

indole [CPD:C00463];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

indolin-2-one [CPD:C12312];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).

History

EC 1.14.14.153 created 2012 as EC 1.14.13.137, transferred 2018 to EC 1.14.14.153

Pathway

ec00402

Benzoxazinoid biosynthesis

ec00999

Biosynthesis of various plant secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology