KEGG ENZYME: 1.14.14.164

ENZYME: 1.14.14.164

Entry

EC 1.14.14.164              Enzyme

Name

fraxetin 5-hydroxylase;
CYP82C4;
fraxetin 5-monooxygenase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

fraxetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5-hydroxylating)

Reaction(IUBMB)

fraxetin + [reduced NADPH---hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12223]

Reaction(KEGG)

R12223

Substrate

fraxetin [CPD:C09265];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

sideretin [CPD:C22007];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.

History

EC 1.14.14.164 created 2018

Pathway

ec00999

Biosynthesis of various plant secondary metabolites

ec01110

Biosynthesis of secondary metabolites

Orthology

K23136

fraxetin 5-hydroxylase

Genes

ATH:	AT4G31940(CYP82C4)

ALY:

9303340

CRB:

17879967

CSAT:

104716994 104720023 104721639 104727626 104730082 104733184

BRP:

103835488

BNA:	106390013 106449600

BOE:

106333001

RSZ:

108821793

THJ:	104803692 104819460 104819461

CPAP:

110813494

CIT:

102608597

CIC:	CICLE_v10003803mg

PVY:	116137768 116140031

MINC:

123228524

TCC:

18591293

GRA:

105769156

GHI:	107888141 107942681

GAB:

108471489

HSYR:

120167556

DZI:	111311379 111314823

GMX:

100811993

GSJ:

114408673

PVU:	PHAVU_009G061600g

VRA:

106760470

VAR:

108342698

VUN:

114162602

VUM:

124824491

CCAJ:

109802833

APRC:

113865890

LJA:	Lj1g3v1615300.1(Lj1g3v1615300.1)

ADU:

107460456

AIP:

107610187

AHF:	112705794 112762412

LANG:

109343928

QSA:	O6P43_018869

FVE:

105350002

PPER:

18789706

PMUM:

103320922

PAVI:

110762562

PDUL:

117615155

MDM:

103441505

MSYL:

126603185

PXB:

103954079

MNT:	112091840 21404129

CSAV:

115725723

RCU:	8260896 8260897 8260900

JCU:	105633709 105633710 105633711

HBR:	110661464 110661466

MESC:

110614589 110615124 110616234

POP:

18104964

PEU:

105130198

PALZ:

118034182 118034206 118036573

JRE:

109010345

CILL:

122297470

CAVE:

132185629

QSU:

112004233

QLO:

115957904

TWL:

120000202

VVI:

100247206

VRI:

117907345

SLY:

101267593

SPEN:

107007174

SOT:

102581162

SSTN:

125861990

SDUL:

129895103

LBB:

132602552

NTA:	107782393 107790829

NSY:

104246870

NTO:

104094857

NAU:

109215771

INI:

109169781

ITR:

116013393

OEU:

111381794

HAN:	110868438 110914130

ECAD:

122609547

LSV:	111876237 111876238 111893788

CCAV:

112511847

CSIN:

114289226 114302463 114311935 114311955

RVL:	131319191 131319630

NNU:	104594945 104602643

MING:

122057355 122057456 122062028 122064336 122064730 122064731 122066479 122069348 122070247 122072865 122072912 122073149 122073602 122074394 122074395 122074740 122074750 122075296 122075812 122075964 122076219 122076251 122077292 122079511 122086196 122086257 122093030

TSS:	122638622 122643304 122643712 122645181 122645182 122645310 122645792 122645793 122645796 122645799 122645805 122646692 122648499 122648500 122648503 122650927 122654093 122654104 122654105 122655608 122665079 122665816 122669424 122669804 122669805 122669806 122672531 122672552

MSIN:

131218600 131218601 131218602 131219075 131219134 131219135 131219136 131219137 131219138 131228921 131229439 131229683 131230491 131231031 131231046 131236884 131247622

NCOL:

116245832 116245835 116245851 116245854 116245899 116245912 116248524 116249848 116249858 116249984 116249996 116250038 116250385 116252370 116252483 116253042 116253192 116253742

» show all

Reference

1 [PMID:29581584]

Authors

Rajniak J, Giehl RFH, Chang E, Murgia I, von Wiren N, Sattely ES

Title

Biosynthesis of redox-active metabolites in response to iron deficiency in plants.

Journal

Nat Chem Biol 14:442-450 (2018)
DOI:10.1038/s41589-018-0019-2

Sequence

[ath:AT4G31940]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.164

IUBMB Enzyme Nomenclature:

1.14.14.164

ExPASy - ENZYME nomenclature database:

1.14.14.164

BRENDA, the Enzyme Database:

1.14.14.164

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (202)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (201)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (5)   
   InterPro (5)   
All databases (221)   

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