Entry Name (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase;
Class Oxidoreductases;BRITE hierarchy
Sysname (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine 8-hydroxylase,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating)
Reaction(IUBMB) (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine + [reduced NADPH---hemoprotein reductase] + O2 = (13S,14R)-13-O-acetyl-1,8-dihydroxy-cis-N-methylcanadine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R11690 ]
Reaction(KEGG) Substrate (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine [CPD:
C21588 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product (13S,14R)-13-O-acetyl-1,8-dihydroxy-cis-N-methylcanadine [CPD:
C21589 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment This cytochrome P-450 (heme-thiolate) enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.
History EC 1.14.14.167 created 2018
Pathway ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K22096 (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
Genes Taxonomy Reference Authors Dang TT, Chen X, Facchini PJ
Title Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.
Journal Reference Authors Li Y, Smolke CD
Title Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
Journal Reference Authors Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD
Title Complete biosynthesis of noscapine and halogenated alkaloids in yeast.
Journal Sequence Other DBs
