KEGG ENZYME: 1.14.14.17

ENZYME: 1.14.14.17

Entry

EC 1.14.14.17               Enzyme

Name

squalene monooxygenase;
squalene epoxidase;
squalene-2,3-epoxide cyclase;
squalene 2,3-oxidocyclase;
squalene hydroxylase;
squalene oxydocyclase;
squalene-2,3-epoxidase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

squalene,NADPH---hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)

Reaction(IUBMB)

squalene + [reduced NADPH---hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R02874]

Reaction(KEGG)

R02874

Substrate

squalene [CPD:C00751];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7, lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].

History

EC 1.14.14.17 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 1.14.99.7, transferred 2011 to EC 1.14.13.132, transferred 2015 to EC 1.14.14.17

Pathway

ec00100

Steroid biosynthesis

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K00511

squalene monooxygenase

Genes

HSA:	6713(SQLE)

PTR:	464383(SQLE)

PPS:	100976805(SQLE)

GGO:	101129462(SQLE)

PON:	100453462(SQLE)

NLE:	100585992(SQLE)

HMH:	116813584(SQLE)

MCC:	706764(SQLE)

MCF:	102118907(SQLE)

MTHB:

126961387

MNI:	105468467(SQLE)

CSAB:

103237411(SQLE)

CATY:

105598691(SQLE)

PANU:

101024819(SQLE)

TGE:	112630089(SQLE)

MLEU:

105554625(SQLE)

RRO:	104662802(SQLE)

RBB:	108538084(SQLE)

TFN:	117079024(SQLE)

PTEH:

111550671(SQLE)

CANG:

105509084(SQLE)

CJC:	100410163(SQLE)

SBQ:	101054084(SQLE)

CIMI:

108305992(SQLE)

CSYR:

103261734(SQLE)

MMUR:

105882727(SQLE)

LCAT:

123626491 123645008(SQLE)

PCOQ:

105823589(SQLE)

OGA:	100943926(SQLE)

MMU:	20775(Sqle)

MCAL:

110310474(Sqle)

MPAH:

110334642(Sqle)

RNO:	29230(Sqle)

MCOC:

116082750(Sqle)

ANU:	117718991(Sqle)

MUN:	110552435(Sqle)

CGE:	100764834(Sqle)

MAUA:

101828754(Sqle)

PROB:

127235377(Sqle)

PLEU:

114694806(Sqle)

MORG:

121461493(Sqle)

MFOT:

126503576

AAMP:

119822620(Sqle)

NGI:	103743909(Sqle)

HGL:	101709317(Sqle)

CPOC:

100732653(Sqle)

CCAN:

109688126(Sqle)

DORD:

105992349(Sqle)

DSP:	122102333(Sqle)

PLOP:

125360436(Sqle)

NCAR:

124988952

MMMA:

107142912(Sqle)

OCU:

100356021

OPI:	101531954(SQLE)

TUP:	102473783(SQLE)

GVR:	103597602(SQLE)

CFA:	608021(SQLE)

CLUD:

112662471(SQLE)

VVP:	112915974(SQLE)

VLG:	121499171(SQLE)

NPO:	129502586(SQLE)

AML:	100465589(SQLE)

UMR:	103661624(SQLE)

UAH:	113252737(SQLE)

UAR:	123797709(SQLE)

ELK:

111146730

LLV:

125097171

MPUF:

101685937(SQLE)

MNP:	132014294(SQLE)

MLK:	131826411(SQLE)

NVS:	122904308(SQLE)

ORO:	101386907(SQLE)

EJU:	114211101(SQLE)

ZCA:	113924202(SQLE)

MLX:	118015202(SQLE)

NSU:	110579242(SQLE)

LWW:	102744035(SQLE)

FCA:	101086537(SQLE)

PYU:	121042961(SQLE)

PCOO:

112859573(SQLE)

PBG:	122495802(SQLE)

PVIV:

125156112(SQLE)

LRUF:

124507796

PTG:	102948681(SQLE)

PPAD:

109273158(SQLE)

PUC:

125924733

AJU:

106986573

HHV:	120231766(SQLE)

BTA:	526535(SQLE)

BOM:	102264644(SQLE)

BIU:	109568596(SQLE)

BBUB:

102411716(SQLE)

BBIS:

104987823(SQLE)

CHX:	102187506(SQLE)

OAS:	100125351(SQLE)

BTAX:

128059437(SQLE)

ODA:	120878917(SQLE)

CCAD:

122450914(SQLE)

MBEZ:

129544169

SSC:	100113409(SQLE)

CFR:	102518096(SQLE)

CBAI:

105082932(SQLE)

CDK:	105096439(SQLE)

VPC:	102542392(SQLE)

BACU:

103015244(SQLE)

BMUS:

118883444(SQLE)

LVE:	103088551(SQLE)

OOR:	101275903(SQLE)

DLE:	111164434(SQLE)

PCAD:

102996556(SQLE)

PSIU:

116742380(SQLE)

NASI:

112397029(SQLE)

ECB:	100067615(SQLE)

EPZ:	103555758(SQLE)

EAI:	106839365(SQLE)

MYB:	102239947(SQLE)

MYD:	102766276(SQLE)

MMYO:

118670987(SQLE)

MLF:	102420731(SQLE)

PKL:	118718421(SQLE)

EFUS:

103287586(SQLE)

MNA:	107539554(SQLE)

DRO:	112315359(SQLE)

SHON:

118988668(SQLE)

AJM:	119064843(SQLE)

PDIC:

114514691(SQLE)

PHAS:

123833168(SQLE)

MMF:	118631492(SQLE)

PPAM:

129084323(SQLE)

HAI:	109383232(SQLE)

RFQ:	117033653(SQLE)

PALE:

102894920(SQLE)

PGIG:

120595652(SQLE)

PVP:	105292551(SQLE)

RAY:	107521591(SQLE)

MJV:	108400205(SQLE)

TOD:	119238151(SQLE)

SARA:

101556612(SQLE)

LAV:	100664731(SQLE)

TMU:

101359006

ETF:	101654543(SQLE)

DNM:	101421617(SQLE)

MDO:	100032247(SQLE)

GAS:	123231957(SQLE)

SHR:	100918180(SQLE)

AFZ:

127544441

PCW:	110193305(SQLE)

OAA:	100076751(SQLE)

GGA:	420335(SQLE)

PCOC:

116227739(SQLE)

MGP:	100546703(SQLE)

CJO:	107310534(SQLE)

TPAI:

128091557(SQLE)

LMUT:

125691209(SQLE)

NMEL:

110394194(SQLE)

APLA:

101802617(SQLE)

ACYG:

106038503(SQLE)

CATA:

118252669(SQLE)

AFUL:

116485727(SQLE)

TGU:	100225604(SQLE)

LSR:	110476988(SQLE)

SCAN:

103814522(SQLE)

PMOA:

120505198(SQLE)

OTC:	121337483(SQLE)

PRUF:

121349874(SQLE)

GFR:	102033103(SQLE)

FAB:	101806873(SQLE)

OMA:	130249902(SQLE)

PHI:	102109574(SQLE)

PMAJ:

107200846(SQLE)

CCAE:

111925120(SQLE)

CCW:	104692651(SQLE)

CBRC:

103623503(SQLE)

ETL:	114065244(SQLE)

ZAB:	102074085(SQLE)

ACHL:

103797105(SQLE)

SVG:	106849516(SQLE)

MMEA:

130574943(SQLE)

HRT:	120751751(SQLE)

FPG:	101920264(SQLE)

FCH:	102054050(SQLE)

CLV:	102090054(SQLE)

EGZ:	104134437(SQLE)

NNI:	104017981(SQLE)

PCRI:

104024695(SQLE)

PLET:

104617099(SQLE)

EHS:

104504707

PCAO:

104040977(SQLE)

ACUN:

113477107(SQLE)

TALA:

104365772(SQLE)

PADL:

103916372(SQLE)

AFOR:

103897248(SQLE)

ACHC:

115340708(SQLE)

HALD:

104310485(SQLE)

HLE:	104837664(SQLE)

AGEN:

126050136

GCL:

127013274

CCRI:

104161456(SQLE)

CSTI:

104550899(SQLE)

CMAC:

104479388(SQLE)

MUI:	104534385(SQLE)

BREG:

104629202(SQLE)

GSTE:

104261844(SQLE)

LDI:	104340528(SQLE)

MNB:	103770063(SQLE)

OHA:	104330492(SQLE)

NNT:	104405133(SQLE)

SHAB:

115618879(SQLE)

DPUB:

104309334(SQLE)

PGUU:

104464945(SQLE)

ACAR:

104518746(SQLE) 104531213

CPEA:

104388689(SQLE)

AVIT:

104272064(SQLE)

CVF:	104282876(SQLE)

RTD:	128906291(SQLE)

CUCA:

104058485(SQLE)

TEO:	104370183(SQLE)

BRHI:

104489273(SQLE)

AAM:	106496303(SQLE)

AROW:

112972845(SQLE)

NPD:	112952744(SQLE)

TGT:	104579911(SQLE)

DNE:	112989163(SQLE)

SCAM:

104144655(SQLE)

ASN:	102368291(SQLE)

AMJ:	102563308(SQLE)

CPOO:

109321952(SQLE)

GGN:	109305187(SQLE)

PSS:	102444614(SQLE)

CMY:	102929627(SQLE)

CCAY:

125632817(SQLE)

DCC:	119852215(SQLE)

CPIC:

101943545(SQLE)

TST:	117873807(SQLE)

CABI:

116826537(SQLE)

MRV:	120399202(SQLE)

ACS:	100557553(sqle)

ASAO:

132775108(SQLE)

PVT:	110080534(SQLE)

SUND:

121929845(SQLE)

PBI:

103062700

PMUR:

107295853(SQLE)

CTIG:

120315456(SQLE)

PGUT:

117668408(SQLE)

APRI:

131196376(SQLE)

PTEX:

113438311(SQLE)

NSS:	113419630(SQLE)

VKO:	123033690(SQLE)

PMUA:

114600258(SQLE)

PRAF:

128417086(SQLE)

ZVI:	118089924(SQLE)

HCG:	128323105(SQLE)

GJA:	107118942(SQLE)

STOW:

125439014(SQLE)

EMC:	129333239(SQLE)

XLA:	108695454(sqle.S) 108719421(sqle.L)

XTR:	100491400(sqle)

NPR:	108789438(SQLE)

RTEM:

120941518(SQLE)

BBUF:

121000908(SQLE)

BGAR:

122937981(SQLE)

MUO:	115480384(SQLE)

GSH:	117353551(SQLE)

DRE:	565329(sqleb) 799528(sqlea)

SRX:	107714342 107719155(sqle)

SANH:

107666801 107686341

SGH:	107556968 107592438

CCAR:

109055982 109056009

CAUA:

113059233 113115850

CGIB:

127974439 128030407

PTET:

122323326(sqleb) 122360855 122360958(sqlea)

LROH:

127178878(sqlea) 127181547(sqleb)

OMC:	131521851(sqlea) 131525154(sqleb)

PPRM:

120462296(sqlea)

RKG:	130100686(sqlea) 130102375(sqleb)

MAMB:

125243770(sqlea) 125275704(sqleb)

CIDE:

127497628 127500651

MASI:

127454463

TROS:

130558187(sqlea)

TDW:	130432315(sqlea)

MANU:

129448752(sqlea)

IPU:	108256332(sqlea)

IFU:	128599566(sqlea)

PHYP:

113532934(sqle)

SMEO:

124375414(sqlea)

TFD:	113658932(sqlea)

TVC:	132840035(sqlea)

AMEX:

103022030(sqle)

CMAO:

118798753(sqlea)

EEE:	113577069(sqle)

CHAR:

105896381(sqlea) 105909038

TRU:	101073594(sqle)

TFS:	130532129(sqlea)

TNG:	GSTEN00015617G001

LCO:	104926267(sqle)

NCC:	104964943(sqle)

TBEN:

117480051(sqlea)

CGOB:

115021330(sqle)

PGEO:

117461103(sqlea)

GACU:

117553874(sqlea)

EMAC:

134862461(sqlea)

ELY:	117266512(sqlea)

EFO:	125893686(sqlea)

PLEP:

121945373(sqlea)

SLUC:

116066669(sqlea)

ECRA:

117946150(sqlea)

ESP:	116691636(sqle)

PFLV:

114557392(sqle)

GAT:	120810464(sqlea)

PPUG:

119197864(sqlea)

AFB:	129109862(sqlea)

CLUM:

117728281(sqlea)

PSWI:

130188007(sqlea)

MSAM:

119898054(sqlea)

SCHU:

122881879(sqlea)

CUD:	121514036(sqlea)

ALAT:

119006824(sqlea)

MZE:	101469229(sqle)

ONL:	100703372(sqle)

OAU:	116320637(sqlea)

OLA:	101165835(sqle)

OML:	112144081(sqlea)

XMA:	102218921(sqle)

XCO:	114143874(sqle)

XHE:	116714625(sqle)

PRET:

103478205(sqle)

PFOR:

103137007(sqle)

PLAI:

106962779(sqle)

PMEI:

106924619(sqle)

GAF:	122831166(sqlea)

PPRL:

129367398(sqlea)

CVG:	107090131(sqle)

CTUL:

119771395(sqlea)

GMU:	124864134(sqlea)

NFU:	107378852(sqle)

KMR:	108234140(sqlea)

ALIM:

106523620(sqle)

NWH:	119410230(sqlea)

AOCE:

111562938(sqle)

MCEP:

125016931(sqlea)

CSEM:

103388631(sqle)

POV:	109631985(sqle)

SSEN:

122772048 122774583(sqlea)

HHIP:

117777255(sqlea)

HSP:	118113113(sqlea)

SMAU:

118313365(sqlea)

LCF:	108887154(sqlea)

SDU:	111227759(sqle)

SLAL:

111658124(sqle)

XGL:	120784387(sqlea)

HCQ:	109507068(sqle)

SSCV:

125975227

SBIA:

133501113(sqlea)

PEE:	133401157(sqlea)

PTAO:

133479732(sqlea)

BPEC:

110171635(sqle)

MALB:

109966629(sqle)

BSPL:

114843703(sqlea)

SJO:	128366599(sqlea)

SASA:

106579093 106605546

STRU:

115177539 115181075

OTW:	112222797 112227598

OMY:	110485563 110511248

OGO:	123997899 124006371

ONE:	115121375 115140935

OKI:	109901053 109901880

OKE:	118364568 127906086

SALP:

111958774 112076800

SNH:	120031445 120048506

CCLU:

121586050(sqlea)

ELS:	105019213(sqle)

SFM:	108940515(sqle)

PKI:	111844075(sqle)

AANG:

118216892(sqlea)

PSPA:

121313129(sqlea)

ARUT:

117400364(sqlea)

PSEX:

120516928(sqlea)

LCM:	102345671 102353148(SQLE) 102363496 102363771 102364039 102364287

CMK:	103187848(sqlea)

RTP:

109919445

CPLA:

122549182(sqlea)

HOC:	132815376(sqlea)

LERI:

129696697(sqlea)

LRJ:	133353211(SQLE)

BFO:

118410114

BBEL:

109480954

SPU:	756574 757019 763532

LPIC:

129279885 129280359 129280485

APLC:

110978788

SKO:

100370736

DPX:	DAPPUDRAFT_71528

PMEO:

129597136

LGI:	LOTGIDRAFT_144418

PVUL:

126818038

PCAN:

112573399

BGT:

106061665

GAE:	121375040 121391435

HRF:

124142800

HRJ:

124275304

OSN:

115228832

LAK:

106169642

TAD:	TRIADDRAFT_63342

AQU:

100632870

ATH:	AT1G58440(XF1) AT2G22830(SQE2) AT4G37760(SQE3) AT5G24140(SQP2) AT5G24150(SQP1) AT5G24160(SQE6)

ALY:	9305037 9308163 9310239 9310240 9310241 9316531 9324278

CRB:	17879593 17881486 17882298 17883036 17889030 17896403

CSAT:

104702819 104706714 104706715 104706717 104706718 104716345 104720986 104729388 104736426 104736427 104736428 104750186 104751922 104770792 104770795 104772519 104787229

EUS:	EUTSA_v10000099mg EUTSA_v10004005mg EUTSA_v10005661mg EUTSA_v10023406mg

BRP:	103838611 103842601 103854873 103854874 103854876 103857940 103863546 103864397 103865842 103874288 103874805

BNA:	106348279 106348280 106366016 106366599 106380094 106380095 106380096 106392124 106392394 106404411 106404424 106415877 106426862 106428446 106432517 106445755 106446452 111211195 125574895 125581325

BOE:	106303240 106307047 106314195 106318641 106321215 106323003 106325308 106339788 106342659

RSZ:	108811538 108818016 108823405 108825489 108837227 108849546 108852195 108855833 130494774 130500427 130505819

THJ:	104798890 104798908 104798909 104801658 104807642 104822879 104823679 104823760

CPAP:

110807845 110809071

CIT:	102610049 102614721 102615022 102616721 102622201 102624867 127899210

CIC:	CICLE_v10000839mg CICLE_v10010276mg CICLE_v10010419mg CICLE_v10010705mg CICLE_v10010782mg CICLE_v10025367mg CICLE_v10029886mg CICLE_v10029969mg

PVY:	116106813 116109253 116109258 116109277 116109282 116122734 116122735 116122737 116131545 116133721

MINC:

123202343 123203376 123221443 123225816 123226912 123228678

TCC:	108660985 18591923 18607297 18607298 18607299 18611338 18611827 18611834

GRA:	105769380 105772828 105778884 105784925 105787701 105795485

GHI:	107898505 107898506 107898507 107898509 107898510 107898512 107905167 107908577 107916766 107930592 107934884 107934890 107934901 107934916 107934957 107935261 107938317 107938857 107950526 107957887

GAB:	108450247 108457979 108458975 108459422 108459602 108460811 108460812 108469738 108474966 108480717 108486331

HSYR:

120121530 120123211 120130132 120145844 120160868 120183196 120183198 120197691 120197693 120198000 120199834 120200008 120200015 120207608 120212152

DZI:	111279674 111281465 111282914 111292612 111298163 111298772 111300707 111308631 111312522 111314901

EGR:	104418420 104419813 104423240 104447805 104449232

GMX:	100795027 100795522 100796946 100800329 100804406 100808856 100810547 100820031

GSJ:	114374663 114385447 114385686 114393911 114397505 114414794 114419444 114421346

PVU:	PHAVU_001G031600g PHAVU_002G216900g PHAVU_006G029400g PHAVU_006G197900g PHAVU_009G074500g

VRA:	106753043 106765138 106765593 106766844 106774500

VAR:	108331915 108338681 108342749 108342876 108344729

VUN:	114164844 114175615 114188185 114188948 114194766

VUM:	124822950 124831100 124836056 124844943 124848568

CCAJ:

109791859 109796770 109808246 109811675 109811686

APRC:

113847564 113848935 113857491 113858000 113864681

MTR:	11415396 25482032 25490000 25496080 25496089

TPRA:

123894256 123909109 123917289 123918094 123918096

CAM:	101491995 101493207 101496784 101508894

PSAT:

127083635 127087972 127091218 127105283 127136761

VVO:	131596439 131596453 131598094 131607573 131660801

LJA:

Lj0g3v0267429.1(Lj0g3v0267429.1) Lj0g3v0267429.2(Lj0g3v0267429.2) Lj0g3v0267429.3(Lj0g3v0267429.3) Lj0g3v0292939.1(Lj0g3v0292939.1) Lj0g3v0298799.2(Lj0g3v0298799.2) Lj1g3v1779010.1(Lj1g3v1779010.1) Lj1g3v1779010.2(Lj1g3v1779010.2) Lj4g3v0412640.1(Lj4g3v0412640.1) Lj5g3v0347610.1(Lj5g3v0347610.1) Lj6g3v2171780.1(Lj6g3v2171780.1) Lj6g3v2171780.2(Lj6g3v2171780.2) Lj6g3v2171780.3(Lj6g3v2171780.3)

ADU:	107468743 107480542 107482392 107495824

AIP:	107605573 107624122 107626262 107638248

AHF:	112697714 112714750 112728665 112740944 112756004 112785023 112791341 112795667

LANG:

109332966 109337353 109345643 109358525

PCIN:

129286320 129294931 129294938 129298552 129299396 129300227 129304809 129304810 129311524

QSA:	O6P43_012478 O6P43_015949 O6P43_019048 O6P43_024512 O6P43_031707 O6P43_031709 O6P43_031742

FVE:	101296607 101297207 101301827 101311715 101312297 101312586 101313166 101313461

RCN:	112169211 112172133 112172174 112172593 112173431 112174075 112174507 112175399 112183737 112192799 112192807 112197445 112199387 112199392 112200311 112200467

PPER:

18766762 18767485 18768153 18775060 18793889

PMUM:

103320605 103334961 103334962 103336172

PAVI:

110745624 110747303 110757217 110757254

PDUL:

117615124 117631045 117636805 117637083

MDM:	103404994 103409320 103420059 103420510 103420543 103428431 103431165 103436286 103436299 103438574 103438709 103441409 103443090 103445174 103455855

MSYL:

126586692 126601280 126603963 126611228 126613713 126623288 126623289 126623290 126623291 126623292 126627999 126628000 126628006 126630583 126632198

PXB:	103931412 103931590 103946237 103946238 103951565 103952120 103952121 103952123 103952682 103967038 103967039 103967055 103967056 103967075

ZJU:	107420604 107425040 107427421 107427466 107427482 112492770

MNT:	112094087 112095292 21385790 21396175

CSAV:

115704166 115712817

CSV:	101204949 101210582 101213038

CMO:	103487810 103493632 103495674

BHJ:	120076479 120077762 120087280

MCHA:

111004801 111010224 111017664 111025080

CMAX:

111471032 111481205 111491959 111496410

CMOS:

111442598 111446533 111454180 111454931 111462746

CPEP:

111788153 111797580 111805616 111811375

RCU:	8265245 8267674 8268892 8272164 8281344

JCU:	105630804(SQE) 105634515 105634535 105634536 105634540 105634542 105634543 105639884

HBR:	110633570 110635155 110635156 110635160 110635163 110642235 110643574 110647259 110652051 110661905 110661906 110665457 110666477 110669811

MESC:

110606759 110615992 110618809 110624242 110624578 110625166 110627423 110628978 122724859 122724879 122724886 122724887 122724888

POP:	18096264 18099572 18105959 18108148 7465918 7497730

PEU:	105107839 105114089 105114092 105117255 105117259 105130487

PALZ:

118028376 118035575 118035773 118040992 118040996 118045758 118050555

JRE:	108983035 108987866 108989032 109001142 109003433 109013467 109022319 118346317

CILL:

122274729 122274730 122274732 122308970 122314750 122315530 122317948 122318877

CAVE:

132170410 132170875 132172209 132189727

QSU:	111985237 111989595 111989596 111990232

QLO:	115960408 115968696 115994670 115994671

TWL:	119982210 119983278 119983769 119986340 120009540 120011244

VVI:	100254037 100260031 100265235 100854014

VRI:	117907890 117911199 117911200 117917303

SLY:	101250012 101252376(bc2.1) 112940012 112940619

SPEN:

107011971 107011974 107017670

SOT:	102579136 102585235

SSTN:

125847696 125854349

SDUL:

129873969 129902522

CANN:

107840150 107851009 107858627 107867273

LBB:	132621802 132627737

NTA:	107761131 107771747 107786596 107821041 107828762 107831617

NSY:	104211864 104224029 104232898

NTO:	104103362 104113280 104115212

NAU:	109210468 109239474

INI:	109161287 109170294 109171408 109177866

ITR:	115999778 116022254 116028770 116029673

SIND:

105159079 105162196 105169793 105172646

OEU:	111365439 111365440 111376794 111380881 111388896 111390117 111401374 111410179 111410519

EGT:	105956088 105961564

SSPL:

121742421 121743295 121761048 121762523 121762922 121765536 121766152 121810949

SMIL:

131001055 131001820 131017851

SHIS:

125200755 125202166 125214423 125217814

APAN:

127246795 127252480 127252482 127254999 127260551 127262341 127263599 127263830 127263906

HAN:	110883742 110885327 110903826 110912718 110936879 110940251

ECAD:

122586576 122590852 122595218 122602792

LSV:	111879628 111900225 111911464 111913279

CCAV:

112506522 112506592 112514431 112516273 112516564 112519150

DCR:	108196765 108199283 108202809 108214582 108219323

CSIN:

114259457 114284236 114298578 114298887 114300785 114323318

RVL:	131328017 131330212 131331436 131335659

AEW:	130758874 130769010 130776567 130780568

BVG:	104894986 104901642

SOE:	110803651 110803950

CQI:	110682470 110685768 110719994 110732064

ATRI:

130798108 130807824

MOF:	131162061 131166829

NNU:	104591228 104609137

MING:

122070260

TSS:	122660088 122661958

PSOM:

113283435 113286643 113288492 113356619

OSA:	4332152 4332153

DOSA:

Os03t0231700-01(Os03g0231700) Os03t0231800-02(Os03g0231800)

OBR:	102712971 102713249

OGL:	127768083 127768084

BDI:

100839945

ATS:

109744486

TDC:	119285011 119291116

TAES:

123085101 123092891 123098170

TUA:

125552432

LPER:

127296319

LRD:

124695081

SBI:

8056854

ZMA:	100274333 100285558

SITA:

101777295

SVS:

117838753

PVIR:

120646775 120689530

PHAI:

112874853

PDA:	103707523 103713674

EGU:	105055883 105061253

MUS:	103978791 103993815 103993817 103994329 103994331 103999437

ZOF:	121972198 121977218 121983819 122036991 122051227 122051228 122053576 122055857

DCT:	110095241 110115472

PEQ:	110023856 110023857 110039210

AOF:	109833188 109834286 109844344

MSIN:

131218840 131228674

NCOL:

116252420 116265744

ATR:

18446877

SMO:	SELMODRAFT_150266 SELMODRAFT_176270

PPP:

112296106

CRE:	CHLRE_17g734644v5

VCN:	VOLCADRAFT_74714

MNG:

MNEG_6310

CSL:	COCSUDRAFT_53930

CVR:	CHLNCDRAFT_137251

APRO:

F751_4796

OLU:	OSTLU_88065

OTA:	OT_ostta08g03180

BPG:	Bathy01g06810

MIS:	MICPUN_60873

MPP:	MICPUCDRAFT_49604(JGI:MicpuC2_49604)

CME:	CYME_CMH256C

GSL:	Gasu_30550

SCE:	YGR175C(ERG1)

SEUB:

DI49_2141

SPAO:

SPAR_G03900

AGO:	AGOS_AAL141C

ERC:

Ecym_6016

KLA:	KLLA0_F15224g

KMX:	KLMA_30204(ERG1)

LTH:	KLTH0B03784g

VPO:	Kpol_2002p90

ZRO:	ZYRO0B10912g

CGR:	CAGL0D05940g

NCS:	NCAS_0A06930(NCAS0A06930)

NDI:	NDAI_0D01990(NDAI0D01990)

TPF:	TPHA_0E03160(TPHA0E03160)

TBL:	TBLA_0C05980(TBLA0C05980) TBLA_0H02130(TBLA0H02130)

TGB:	HG536_0E04540

TDL:	TDEL_0E04440(TDEL0E04440)

KAF:	KAFR_0D01720(KAFR0D01720)

KNG:	KNAG_0H02660(KNAG0H02660)

ZMK:	HG535_0C05190

PPA:	PAS_chr3_0124

DHA:	DEHA2G14300g

PIC:	PICST_75910(ERG1)

PGU:	PGUG_04402

SPAA:

SPAPADRAFT_62808(ERG1)

LEL:	PVL30_000683(ERG1)

CAL:	CAALFM_C108590CA(ERG1)

CTP:	CTRG_05483

COT:	CORT_0A09800

CDU:	CD36_08100

CTEN:

CANTEDRAFT_93607

YLI:	YALI0E15730g

CLU:	CLUG_01944

CLUS:

A9F13_02g03509

CAUR:

CJI96_0000987

PKZ:	C5L36_0C07670

BNN:	FOA43_003086

BBRX:

BRETT_003315

OPA:	HPODL_02301

SLUD:

SCDLUD_004479

NCR:

NCU08280

NTE:	NEUTE1DRAFT116406(NEUTE1DRAFT_116406)

SMP:	SMAC_00934

PAN:	PODANSg7130

PBEL:

QC761_605940(ERG1)

PPSD:

QC762_605940(ERG1)

PPSP:

QC763_605940(ERG1)

PPSA:

QC764_605940(ERG1)

TTT:	THITE_165536 THITE_2115532

MTM:	MYCTH_2299088

CTHR:

CTHT_0018980 CTHT_0032780

MGR:

MGG_06139

PPEI:

PpBr36_02970

PGRI:

PgNI_01730

TMN:	UCRPA7_7904

SSCK:

SPSK_03260

FGR:	FGSG_06215

FPU:	FPSE_02575

FPOA:

FPOAC1_009199

FVN:	FVRRES_09831

FVR:	FVEG_06181

FOX:	FOXG_08495

NHE:	NECHADRAFT_34081

FFC:	NCS54_00240700

FKR:	NCS57_00236200

FMU:	J7337_004601

TRE:	TRIREDRAFT_121230

TRR:	M419DRAFT_109136

MAW:

MAC_01304

MAJ:

MAA_06325

PCHM:

VFPPC_05078

CMT:

CCM_07184

AMUS:

LMH87_010514

PLJ:	VFPFJ_06332

PTKZ:

JDV02_000201(ERG1)

VAL:	VDBG_01618

VDA:	VDAG_01934

CFJ:	CFIO01_07855

CLUP:

CLUP02_15020

CHIG:

CH63R_04644

SAPO:

SAPIO_CDS8059

ELA:	UCREL1_10241

PFY:	PFICI_04283

SSL:	SS1G_13084

BFU:	BCIN_01g00360(Bcerg1)

MBE:

MBM_00629

PSCO:

LY89DRAFT_598274 LY89DRAFT_703032 LY89DRAFT_720744

GLZ:	GLAREA_08350

AFM:	AFUA_5G07780

ACT:	ACLA_012730

NFI:	NFIA_079490

AOR:	AO090701000685

ANG:	An03g03770

AFV:	AFLA_005205

ALUC:

AKAW2_50776S(ERG1)

ACHE:

ACHE_21335S(ERG1)

PCS:	N7525_004825

PDP:	PDIP_52510

POU:	POX_a00343

TMF:	EYB26_002253

TRG:	TRUGW13939_08216

CIM:	CIMG_06149

CPW:	CPC735_027040

URE:	UREG_04240

PBL:	PAAG_08773

PBN:	PADG_02704

ABE:

ARB_06092

TVE:

TRV_00314

AJE:	HCAG_02957

BGH:	BDBG_08449

PNO:	SNOG_12929

PTE:

PTT_17609

BZE:	COCCADRAFT_7296

BSC:	COCSADRAFT_37658

BOR:	COCMIDRAFT_96504

AALT:

CC77DRAFT_1015578

ARAB:

EKO05_0011393

ZTR:	MYCGRDRAFT_108597(ERG1)

PFJ:	MYCFIDRAFT_203278

FFU:	CLAFUR5_06476

CBET:

CB0940_08405

BCOM:

BAUCODRAFT_65358

TML:	GSTUM_00004857001

SPO:	SPBC713.12(erg1)

SOM:	SOMG_01463(erg1)

CNE:

CND06110

CNB:

CNBD0290

CNG:	CNAG_06829

CGI:	CGB_I0350C

CDEU:

CNBG_5896

TMS:	TREMEDRAFT_42427

TASA:

A1Q1_01672

CCAC:

CcaHIS019_0406150(ERG1)

TVS:	TRAVEDRAFT_31841

DSQ:	DICSQDRAFT_59311

PCO:	PHACADRAFT_263119

SHS:	STEHIDRAFT_106330

HIR:	HETIRDRAFT_323724

PSQ:	PUNSTDRAFT_145584

ADL:	AURDEDRAFT_115335

FME:	FOMMEDRAFT_91853

GTR:	GLOTRDRAFT_128167

RSX:	RhiXN_04699

LBC:	LACBIDRAFT_190855

CCI:	CC1G_03119 CC1G_03987

ABP:	AGABI1DRAFT69774(AGABI1DRAFT_69774)

ABV:	AGABI2DRAFT205454(AGABI2DRAFT_205454)

PCUB:

JR316_0007707

MRR:	Moror_7244

E1B28_001681

SCM:	SCHCO_02514140(SCHCODRAFT_02514140) SCHCO_02645878(SCHCODRAFT_02645878)

CPUT:

CONPUDRAFT_160880

SLA:	SERLADRAFT_356400

WSE:	WALSEDRAFT_39579

WIC:	J056_000439

UMA:	UMAG_02398

PFP:	PFL1_01556

SGRA:

EX895_004854

MGL:

MGL_0127

MRT:

MRET_1190

MSYM:

MSY001_0512

PGR:	PGTG_06567

PTRC:

PtA15_16A79

PSTR:

Pst134EA_028997

MLR:	MELLADRAFT_47732

DDI:	DDB_G0293584(sqle)

DPP:	DICPUDRAFT_49927

DFA:	DFA_07098(sqle)

ACAN:

ACA1_157860

SPAR:

SPRG_11641

TBR:	Tb11.02.0780

TBG:	TbgDal_XI3640

TCR:

509589.20

LMA:	LMJF_13_1620

LIF:	LINJ_13_1360

LDO:	LDBPK_131360

LMI:	LMXM_13_1620

LBZ:	LBRM_13_1480

LPAN:

LPMP_131490

NGR:	NAEGRDRAFT_62881 NAEGRDRAFT_78243

MCA:

MCA2872

METU:

GNH96_03485

MMEO:

OOT43_13970

MAH:	MEALZ_0767

MBUR:

EQU24_17590

MMAI:

sS8_2585

MSZE:

MSZNOR_2693

MMOB:

F6R98_20990

MEIN:

methR_P0929

MISZ:

MishRS11D_32920

MCG:

GL4_3111

MFB:	MFUL124B02_14120

CCX:	COCOR_01775(ubiF)

SUR:	STAUR_5420

MRM:	A7982_03039

LLU:	AKJ09_09405

SRK:	FGW37_00300

GOG:	C1280_23610

GMS:	SOIL9_22870

FTJ:

FTUN_7823

FTE:	Fluta_3221

CRM:	K6119_02985

» show all

Reference

1 [PMID:5918046]

Authors

Cory EJ, Russey WE, Ortiz de Montellano PR.

Title

2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene.

Journal

J Am Chem Soc 88:4750-1 (1966)
DOI:10.1021/ja00972a056

Reference

2 [PMID:13438881]

Authors

TCHEN TT, BLOCH K.

Title

On the conversion of squalene to lanosterol in vitro.

Journal

J Biol Chem 226:921-30 (1957)

Reference

3 [PMID:5918048]

Authors

Van Tamelen EE, Willett JD, Clayton RB, Lord KE.

Title

Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol.

Journal

J Am Chem Soc 88:4752-4 (1966)
DOI:10.1021/ja00972a058

Reference

4 [PMID:5438357]

Authors

Yamamoto S, Bloch K.

Title

Studies on squalene epoxidase of rat liver.

Journal

J Biol Chem 245:1670-4 (1970)

Reference

5 [PMID:234459]

Authors

Ono T, Bloch K

Title

Solubilization and partial characterization of rat liver squalene epoxidase.

Journal

J Biol Chem 250:1571-9 (1975)

Reference

6 [PMID:8358382]

Authors

Satoh T, Horie M, Watanabe H, Tsuchiya Y, Kamei T

Title

Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae.

Journal

Biol Pharm Bull 16:349-52 (1993)
DOI:10.1248/bpb.16.349

Reference

7 [PMID:12467639]

Authors

Chugh A, Ray A, Gupta JB

Title

Squalene epoxidase as hypocholesterolemic drug target revisited.

Journal

Prog Lipid Res 42:37-50 (2003)
DOI:10.1016/S0163-7827(02)00029-2

Reference

8 [PMID:17852349]

Authors

He F, Zhu Y, He M, Zhang Y

Title

Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng.

Journal

DNA Seq 19:270-3 (2008)
DOI:10.1080/10425170701575026

Sequence

[ag:ABE60738]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.17

IUBMB Enzyme Nomenclature:

1.14.14.17

ExPASy - ENZYME nomenclature database:

1.14.14.17

BRENDA, the Enzyme Database:

1.14.14.17

CAS:

9029-62-3

DBGET integrated database retrieval system