KEGG ENZYME: 1.14.14.21

ENZYME: 1.14.14.21

Entry

EC 1.14.14.21               Enzyme

Name

dibenzothiophene monooxygenase;
dszC (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

dibenzothiophene,FMNH2:oxygen oxidoreductase

Reaction(IUBMB)

dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene-5,5-dioxide + 2 FMN + 2 H2O (overall reaction) [RN:R11163];
(1a) dibenzothiophene + FMNH2 + O2 = dibenzothiophene-5-oxide + FMN + H2O [RN:R11161];
(1b) dibenzothiophene-5-oxide + FMNH2 + O2 = dibenzothiophene-5,5-dioxide + FMN + H2O [RN:R11162]

Reaction(KEGG)

R11161 R11162 R11163

Substrate

dibenzothiophene [CPD:C20125];
FMNH2 [CPD:C01847];
O2 [CPD:C00007];
dibenzothiophene-5-oxide [CPD:C21149]

Product

dibenzothiophene-5,5-dioxide [CPD:C21150];
FMN [CPD:C00061];
H2O [CPD:C00001];
dibenzothiophene-5-oxide [CPD:C21149]

Comment

This bacterial enzyme catalyses the first two steps in the desulfurization pathway of dibenzothiophenes, the oxidation of dibenzothiophene into dibenzothiophene sulfone via dibenzothiophene-5-oxide. The enzyme forms a two-component system with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42) encoded by the dszD gene, which also interacts with EC 1.14.14.22, dibenzothiophene sulfone monooxygenase.

History

EC 1.14.14.21 created 2016

Orthology

K22219

dibenzothiophene monooxygenase

Genes

MAV:

MAV_3806