KEGG ENZYME: 1.14.14.55

ENZYME: 1.14.14.55

Entry

EC 1.14.14.55               Enzyme

Name

quinine 3-monooxygenase;
CYP3A4 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

quinine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase

Reaction(IUBMB)

quinine + [reduced NADPH---hemoprotein reductase] + O2 = 3-hydroxyquinine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R05727]

Reaction(KEGG)

R05727

Substrate

quinine [CPD:C06526];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

3-hydroxyquinine [CPD:C07344];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein.

History

EC 1.14.14.55 created 2000 as EC 1.14.13.67, transferred 2017 to EC 1.14.14.55

Orthology

K17689

cytochrome P450 family 3 subfamily A4

Genes

HSA:	1576(CYP3A4)

PTR:	463582(CYP3A4)

PPS:	100976899(CYP3A4)

GGO:

101149513

PON:

100436782

NLE:

100593175

MCC:	678670(CYP3A4)

MCF:	102144258(CYP3A4)

MTHB:

126950475

MNI:

105497389

CSAB:

103246766

CATY:

105584402

PANU:

101026757

TGE:

112621193

MLEU:

105543708

RRO:

104673585

RBB:

108538168

TFN:

117072034

PTEH:

111530171 111534893

CANG:

105513064

CJC:	100404344(CYP3A4)

SBQ:

101037403

CIMI:

108308036(CYP3A4)

CSYR:

103252931

MMUR:

105868328 105868331

LCAT:

123631591 123631593

PCOQ:

105806078

OGA:

100948865

» show all

Reference

1 [PMID:1578365]

Authors

Relling MV, Evans R, Dass C, Desiderio DM, Nemec J.

Title

Human cytochrome P450 metabolism of teniposide and etoposide.

Journal

J Pharmacol Exp Ther 261:491-6 (1992)

Reference

2 [PMID:9088578]

Authors

Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S.

Title

Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine.

Journal

Br J Clin Pharmacol 43:245-52 (1997)
DOI:10.1046/j.1365-2125.1997.00556.x

Sequence

[hsa:1576]

Reference

3 [PMID:9456308]

Authors

Zhao XJ, Kawashiro T, Ishizaki T.

Title

Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.

Journal

Drug Metab Dispos 26:188-91 (1998)

Sequence

[hsa:1576]

Reference

4 [PMID:8968357]

Authors

Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T.

Title

Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.

Journal

J Pharmacol Exp Ther 279:1327-34 (1996)

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.55

IUBMB Enzyme Nomenclature:

1.14.14.55

ExPASy - ENZYME nomenclature database:

1.14.14.55

BRENDA, the Enzyme Database:

1.14.14.55

CAS:	50812-30-1 213327-78-7

All links

Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (31)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (6)   
   InterPro (6)   
All databases (56)   

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