Entry
Name
carnosic acid synthase;
CYP76AK6;
CYP76AK7;
CYP76AK8
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
11-hydroxyferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
11-hydroxyferruginol + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = carnosic acid + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O [RN:
R11973 ]
Reaction(KEGG)
Substrate
11-hydroxyferruginol [CPD:
C21796 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
carnosic acid [CPD:
C21818 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the plants Salvia pomifera (apple sage), S. miltiorrhiza (red sage), S. fruticosa (Greek sage) and Rosmarinus officinalis (Rosemary).
History
EC 1.14.14.61 created 2018
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
Reference
Authors
Ignea C, Athanasakoglou A, Ioannou E, Georgantea P, Trikka FA, Loupassaki S, Roussis V, Makris AM, Kampranis SC
Title
Carnosic acid biosynthesis elucidated by a synthetic biology platform.
Journal
Sequence
Reference
Authors
Scheler U, Brandt W, Porzel A, Rothe K, Manzano D, Bozic D, Papaefthimiou D, Balcke GU, Henning A, Lohse S, Marillonnet S, Kanellis AK, Ferrer A, Tissier A
Title
Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast.
Journal
Sequence
Other DBs