KEGG   ENZYME: 1.14.14.62
Entry
EC 1.14.14.62               Enzyme                                 
Name
salviol synthase;
CYP71BE52
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
ferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (salviol-forming)
Reaction(IUBMB)
ferruginol + [reduced NADPH---hemoprotein reductase] + O2 = salviol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11974]
Reaction(KEGG)
R11974
Substrate
ferruginol [CPD:C09092];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
salviol [CPD:C21819];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia pomifera (apple sage).
History
EC 1.14.14.62 created 2018
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22634  salviol synthase
Reference
1  [PMID:26976595]
  Authors
Ignea C, Athanasakoglou A, Ioannou E, Georgantea P, Trikka FA, Loupassaki S, Roussis V, Makris AM, Kampranis SC
  Title
Carnosic acid biosynthesis elucidated by a synthetic biology platform.
  Journal
Proc Natl Acad Sci U S A 113:3681-6 (2016)
DOI:10.1073/pnas.1523787113
  Sequence
[ag:ALM25794]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.62
IUBMB Enzyme Nomenclature: 1.14.14.62
ExPASy - ENZYME nomenclature database: 1.14.14.62
BRENDA, the Enzyme Database: 1.14.14.62

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (5)   
   InterPro (5)   
All databases (21)   

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