KEGG ENZYME: 1.14.14.96

ENZYME: 1.14.14.96

Entry

EC 1.14.14.96               Enzyme

Name

5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase;
5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase;
coumaroylquinate(coumaroylshikimate) 3'-monooxygenase;
CYP98A3 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

trans-5-O-(4-coumaroyl)-D-quinate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating)

Reaction(IUBMB)

trans-5-O-(4-coumaroyl)-D-quinate + [reduced NADPH---hemoprotein reductase] + O2 = trans-5-O-caffeoyl-D-quinate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R04342]

Reaction(KEGG)

R04342;
(other) R06582

Substrate

trans-5-O-(4-coumaroyl)-D-quinate [CPD:C12208];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

trans-5-O-caffeoyl-D-quinate [CPD:C00852];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein, found in plants. It also acts on trans-5-O-(4-coumaroyl)shikimate.

History

EC 1.14.14.96 created 1990 as EC 1.14.13.36, transferred 2018 to EC 1.14.14.96

Pathway

ec00940

Phenylpropanoid biosynthesis

ec00941

Flavonoid biosynthesis

ec00945

Stilbenoid, diarylheptanoid and gingerol biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K09754

5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase

Genes

ATH:	AT2G40890(CYP98A3)

ALY:

9315964

CRB:

17887658

CSAT:

104782574 104785308 104792955

EUS:	EUTSA_v10016538mg

BRP:	103857960 103865848 103866522

BNA:	106352767 106386334 106391625 106395719 106431114 106438010

BOE:	106335822 106340718 106342398

RSZ:	108847330 108848401 108858042

THJ:

104803227

CPAP:

110811301

CIT:	102623337 102624231 127902134

CIC:	CICLE_v10000848mg CICLE_v10003647mg CICLE_v10011520mg CICLE_v10019813mg

PVY:

116130453

MINC:

123211020 123211225 123224750

TCC:

18598608

GRA:	105782306 105786247

GHI:	107920919 107935532 107950342 121229624

GAB:	108464295 108466431

HSYR:

120139846 120154034

DZI:

111293639

EGR:	104443712 104443731 104443755 104454510

GMX:	100811080 606506(CYP98A2)

GSJ:	114399785 114406591

PVU:	PHAVU_001G117900g

VRA:

106753926

VAR:

108346061

VUN:

114186352

VUM:

124835773

CCAJ:

109802555

APRC:

113861260

MTR:

120576930

TPRA:

123888242

CAM:

101502624

PSAT:

127126484

VVO:	131609986 131622232

LJA:	Lj1g3v4081860.1(Lj1g3v4081860.1)

ADU:

107494128

AIP:

107604697

AHF:	112696779 112754637

LANG:

109326958

PCIN:

129311613

QSA:	O6P43_006317 O6P43_022834

FVE:

101310387

RCN:

112191575

PPER:

18789678 18789708 18789709 18792412

PMUM:

103319005 103319006 103319007

PAVI:

110765625 110765626 110765627 110765628 110771536

PDUL:

117612862 117616059 117616060 117629116

MDM:	103402429 103425389 103428961 103441965

MSYL:

126599158 126603427 126605902 126631773 126631775

PXB:	103944996 103944997 103944999 103946365 103946366

ZJU:

107431535

MNT:

21410476

CSAV:

115712743 115724660

CSV:

101217257

CMO:

103486874

BHJ:

120091747

CMAX:

111482281

CMOS:

111441713

CPEP:

111790179

RCU:	8277408 8277879 8277880

JCU:

105636120

HBR:

110668477

MESC:

110621178

POP:	18106094 7458907 7495679

PEU:	105136908 105137345

PALZ:

118033187 118033188 118052995

JRE:	109008126 109008127 109019007

CILL:

122275816 122276443 122278307

CAVE:

132161799 132161912

QSU:	112007479 112007503

QLO:

115953326

TWL:

119992803

VVI:

100263633

VRI:

117920828

SLY:	101246092 101247849 101261765 101262063 101262367

SPEN:

107001769 107001863 107002593 107008188 107028331

SOT:	102578406 102578747 102586130 102590105 102590484 102590830 102590870 102606401

SSTN:

125863836 125865331 125865642 125865643 125865644 125865645 125871059

SDUL:

129876173 129876783 129876993 129877011 129886387 129887625

CANN:

107839366 107844023 107844024 107844025

LBB:	132607582 132607583 132607584 132607585 132607586 132607587 132626332 132645355

NTA:	107767804 107768690 107771987 107792896 107797681 107800961 107803600 107824233(CYP98A33v1)

NSY:	104216569 104221515 104228627 104235549

NTO:	104088297 104092594 104112912 104119156

NAU:	109221014 109228215 109239726 109239730

INI:

109159148

ITR:	115996353 116029460

SIND:

105162700 105172202

OEU:	111391169 111401521

EGT:	105949334 105949335 105951765 105951768 105951769 105963605

SSPL:

121747388 121747439 121751565 121753302 121804071 121805425 121805775 121806378 121808561

SMIL:

130990242 131006470 131022484 131022485

SHIS:

125189439 125192111 125194298 125194318 125194375 125211920 125213897

APAN:

127256589 127260999

HAN:	110865896 110895770

ECAD:

122579549 122582247

LSV:	111877005 111891710 111908828 111919428

CCAV:

112504027 112512472

DCR:	108209804 108227431

CSIN:

114298795 114303480 114303482

RVL:	131323005 131323006 131323008

AEW:	130755199 130777412 130786255

BVG:	104887604 104889547 104889649 104889748

SOE:	110778982 110779503 110799229

CQI:	110709209 110711729 110714717 110714951 110717575 110720052

ATRI:

130800658 130821286 130827890

MOF:	131146393 131160666

NNU:

104588272

MING:

122063491 122063496 122068462 122069164 122088749

TSS:	122666848 122669889

PSOM:

113298939 113358675

OSA:

4339188

DOSA:

Os05t0494000-01(Os05g0494000)

OBR:

102712257

OGL:	127752952 127773835

BDI:

100835531

ATS:	109731922 109752053 109757203 109771149 109775586

TDC:	119269306 119277305 119284878 119348794

TAES:

123060768 123062331 123071098 123079468 123100799 123108593 123137844 123182452

TUA:	125506560 125522601 125545066

LPER:

127318794 127344160

LRD:	124662229 124707437

SBI:	8077042 8082405

ZMA:	100191539 100274274

SITA:

101771055

SVS:

117849885

PVIR:

120665065 120673263 120698273

PHAI:

112887100 112894578

PDA:	103705056 103706282

EGU:	105033349 105052441

MUS:

103995155

ZOF:	121971833 122002816 122007084 122030545

DCT:

110101632

PEQ:

110024997

AOF:

109819911

MSIN:

131226852 131227290 131227703 131227845 131227846

NCOL:

116245980

ATR:	18427105 18441256

SMO:	SELMODRAFT_450942(C3'H1-1) SELMODRAFT_450943(C3'H1-2)

PPP:

112275074

» show all

Reference

1 [PMID:2821918]

Authors

Kuhnl T, Koch U, Heller W, Wellmann E.

Title

Chlorogenic acid biosynthesis: characterization of a light-induced microsomal 5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase from carrot (Daucus carota L.) cell suspension cultures.

Journal

Arch Biochem Biophys 258:226-32 (1987)
DOI:10.1016/0003-9861(87)90339-0

Reference

2 [PMID:11429408]

Authors

Schoch G, Goepfert S, Morant M, Hehn A, Meyer D, Ullmann P, Werck-Reichhart D

Title

CYP98A3 from Arabidopsis thaliana is a 3'-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway.

Journal

J Biol Chem 276:36566-74 (2001)
DOI:10.1074/jbc.M104047200

Sequence

[ath:AT2G40890]

Reference

3 [PMID:11967091]

Authors

Franke R, Humphreys JM, Hemm MR, Denault JW, Ruegger MO, Cusumano JC, Chapple C

Title

The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism.

Journal

Plant J 30:33-45 (2002)
DOI:10.1046/j.1365-313X.2002.01266.x

Sequence

[ath:AT2G40890]

Reference

4 [PMID:19779199]

Authors

Matsuno M, Compagnon V, Schoch GA, Schmitt M, Debayle D, Bassard JE, Pollet B, Hehn A, Heintz D, Ullmann P, Lapierre C, Bernier F, Ehlting J, Werck-Reichhart D

Title

Evolution of a novel phenolic pathway for pollen development.

Journal

Science 325:1688-92 (2009)
DOI:10.1126/science.1174095

Sequence

[ath:AT2G40890]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.96

IUBMB Enzyme Nomenclature:

1.14.14.96

ExPASy - ENZYME nomenclature database:

1.14.14.96

BRENDA, the Enzyme Database:

1.14.14.96

CAS:	112131-08-5

DBGET integrated database retrieval system