KEGG ENZYME: 1.14.15.30

ENZYME: 1.14.15.30

Entry

EC 1.14.15.30               Enzyme

Name

3-ketosteroid 9alpha-monooxygenase;
KshA;
3-ketosteroid 9alpha-hydroxylase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

androsta-1,4-diene-3,17-dione,[reduced ferredoxin]:oxygen oxidoreductase (9alpha-hydroxylating)

Reaction(IUBMB)

androsta-1,4-diene-3,17-dione + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O [RN:R09860]

Reaction(KEGG)

R09860

Substrate

androsta-1,4-diene-3,17-dione [CPD:C20144];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

9alpha-hydroxyandrosta-1,4-diene-3,17-dione [CPD:C14909];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]

Comment

The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It forms a two-component system with a ferredoxin reductase (KshB). The enzyme contains a Rieske-type iron-sulfur center and non-heme iron. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.

History

EC 1.14.15.30 created 2012 as EC 1.14.13.142, transferred 2018 to EC 1.14.15.30

Pathway

ec00984

Steroid degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K15982

3-ketosteroid 9alpha-monooxygenase subunit A

K15983

3-ketosteroid 9alpha-monooxygenase subunit B

Genes

RGL:	CS053_01730 CS053_01930

VAF:	D1115_22765 D1115_23260

PSG:	G655_23840

PRE:	PCA10_12240(kshA) PCA10_43650(kshB)

PFUW:

KF707C_11570 KF707C_11880

PNT:	G5B91_19005

PPUT:

L483_14105 L483_14320

PPUN:

PP4_26740(kshA) PP4_27180(kshB)

PVR:	PverR02_11715 PverR02_11735

PPUU:

PputUW4_01666 PputUW4_01678

PKC:	PKB_4313(ksha1) PKB_4319(kshB) PKB_4338(ksha3)

PFZ:	AV641_09605

PLQ:	AA042_00420 AA042_20380

PPSY:

AOC04_06430 AOC04_07880

PSET:

THL1_1304 THL1_4407

PSIL:

PMA3_11750 PMA3_11875

PKE:	DLD99_14675 DLD99_14730

PUM:	HGP31_20625 HGP31_20745

PPSH:

G5J76_13535 G5J76_17295

PLAL:

FXN65_05725 FXN65_21125

PKH:	JLK41_05750 JLK41_05865

PPRG:

HU725_015180

PAZE:

KSS91_19205 KSS91_19265

PTAE:

NCTC10697_01839(kshA) NCTC10697_02066(hmp_2)

PCAV:

D3880_17050 D3880_17450

PPHN:

HU825_08370 HU825_14425 HU825_14710

PIZ:	LAB08_R40790 LAB08_R40910

PKM:	PZ739_11585 PZ739_11800

PSC:	A458_17160

PSH:	Psest_3453

PSTU:

UIB01_04060

PSED:

DM292_14720

PCHL:

LLJ08_16585

PBM:	CL52_03850 CL52_10355

PKG:	LW136_18030

SDEG:

GOM96_01420 GOM96_01715 GOM96_13715

PZD:	KQ248_00520

HARR:

HV822_17640 HV822_17935

PPHA:

BVH74_17575 BVH74_17920

KAK:	Kalk_07500

SPL:	Spea_2121 Spea_2130

SHL:	Shal_2093 Shal_2102

COLW:

A3Q33_18555 A3Q33_18810

CBER:

B5D82_11010 B5D82_11285

PHA:	PSHAa0878 PSHAa2137

PTN:	PTRA_a1005(kshB) PTRA_a2590(kshA)

PNG:	PNIG_a1057(kshB) PNIG_a2784(kshA)

SNAN:

I6N98_00555 I6N98_01445 I6N98_05770 I6N98_10760

ZAL:	AZF00_00470 AZF00_04635 AZF00_12085 AZF00_12900 AZF00_15655

HJA:	BST95_04800

HALC:

EY643_17500

AFUS:

EYZ66_12990 EYZ66_13035

PAQM:

E0F26_07235 E0F26_07250 E0F26_07320

ALCA:

ASALC70_02445(kshA)

AXE:

P40_21405

MSEC:

LN244_04810 LN244_04920

MRZ:	KDW95_00805 KDW95_00865

ENW:	MJO57_10955 MJO57_21295

EMP:	EZMO1_1334(kshB) EZMO1_1339(kshA) EZMO1_2690 EZMO1_3801

SOK:	D0B54_03435 D0B54_05260 D0B54_05645 D0B54_08470 D0B54_08675

SINI:

GT972_09345

FCE:	JN531_005745 JN531_007625

GPB:	HDN1F_02750

AQS:	DKK66_00835

AQL:	BXU06_10045

RIN:	ACS15_4367 ACS15_4387 ACS15_4390

REH:	H16_B0643(h16_B0643) H16_B0672(hcaE)

CNC:	CNE_2c05890 CNE_2c06190(kshA) CNE_BB1p00120(kshA)

CUH:	BJN34_30925 BJN34_31150

REU:	Reut_A1546 Reut_A1576

RME:

Rmet_0543

CTI:	RALTA_B0492 RALTA_B0514

CBW:	RR42_m2029 RR42_s2318 RR42_s2340

CGD:	CR3_2920(kshA)

CCUP:

BKK81_32785

CUP:	BKK80_23495

CUU:	BKK79_28795

COX:	E0W60_08160 E0W60_08305

CUK:	KB879_20655 KB879_20805

BMA:

BMAA1220

BMV:	BMASAVP1_0187

BML:	BMA10229_0463

BMN:	BMA10247_A1112

BMAL:

DM55_4293

BMAE:

DM78_3877

BMAQ:

DM76_3245

BMAI:

DM57_10905

BMAF:

DM51_4883

BMAZ:

BM44_4256

BMAB:

BM45_3379

BPS:

BPSS0996

BPM:	BURPS1710b_A2607

BPL:	BURPS1106A_A1377

BPD:	BURPS668_A1464

BPSE:

BDL_4290

BPSM:

BBQ_5138

BPSU:

BBN_4458

BPSD:

BBX_6131

BPZ:	BP1026B_II1091

BPQ:	BPC006_II1385

BPK:

BBK_6151

BPSH:

DR55_4337

BPSA:

BBU_5033

BPSO:

X996_4235

BUT:

X994_6124

BUR:	Bcep18194_B1416 Bcep18194_B1448

BCJ:	BCAM1620 BCAM1644

BCEN:

DM39_3466 DM39_6206(hmp) DM39_6233(kshA)

BCEO:

I35_5481 I35_5504

BCT:	GEM_4012 GEM_4096 GEM_4102

BCED:

DM42_6314(hmp) DM42_6338(kshA)

BCEP:

APZ15_30835 APZ15_31110

BPYR:

ABD05_27655 ABD05_27770

BCON:

NL30_03965 NL30_04080

BDF:	WI26_21190 WI26_21235 WI26_21355

BTEI:

WS51_05735 WS51_05845

BPSL:

WS57_05865 WS57_06000 WS57_06445

BMEC:

WJ16_26825 WJ16_26955

BSTL:

BBJ41_21390 BBJ41_21510 BBJ41_35425

BANN:

JFN94_25695 JFN94_25735 JFN94_26155

BARI:

NLX30_30000 NLX30_30120 NLX30_35345

BAEN:

L3V59_21795 L3V59_21920

BGD:	bgla_2g02180

BURK:

DM992_32470 DM992_32590

BFN:	OI25_4592 OI25_4611

PBRY:

NDK50_32895 NDK50_32990

PPAI:

E1956_08275 E1956_20140 E1956_37110 E1956_37205

PVE:	UC34_06905 UC34_06920

CABA:

SBC2_48790(kshB_1) SBC2_48980(kshA)

APES:

FOC84_00230

CTT:	CtCNB1_1306 CtCNB1_1359

CTES:

O987_07520 O987_07770

CRJ:	QMY55_06885 QMY55_07050

HYN:	F9K07_31150

DIH:	G7047_09735 G7047_10060

AZI:	AzCIB_1457 AzCIB_1462

AZD:	CDA09_09680 CDA09_09705

THU:	AC731_008070 AC731_008185

THAU:

C4PIVTH_4166(kshB) C4PIVTH_4177

THK:	CCZ27_15785

NAR:	Saro_3601 Saro_3649 Saro_3666

NPP:	PP1Y_Mpl3383

NPN:	JI59_09815

NOV:	TQ38_027405

NOT:	C7W88_20195 C7W88_20485 C7W88_20690

SPHK:

SKP52_00800

SWI:	Swit_1829 Swit_2053 Swit_3307

SPHD:

HY78_09015 HY78_15255 HY78_16435

RDI:	CMV14_16795 CMV14_16825

SPHM:

G432_11540 G432_14050 G432_14385 G432_16975

SSAN:

NX02_07805 NX02_17130

SKR:	BRX40_00225 BRX40_00230

SPKC:

KC8_00700 KC8_06855 KC8_08825 KC8_10270 KC8_14070 KC8_16645 KC8_19680

SPHA:

D3Y57_15525

SLAN:

GV829_01745

SBIN:

SBA_ch2_3940

SYB:	TZ53_23495

SPHB:

EP837_02947 EP837_03216 EP837_03246 EP837_03584 EP837_03637

SPHJ:

BSL82_11680 BSL82_11870

PHAO:

HF685_05250 HF685_05340 HF685_05370

PHZ:	CHX26_05450

NTD:	EGO55_02315 EGO55_02665 EGO55_03045 EGO55_04130 EGO55_13445 EGO55_16290 EGO55_16310

CAEN:

K5X80_01135 K5X80_05620 K5X80_05965 K5X80_14960

ADE:

Adeh_0398

ACP:	A2cp1_0427

ANK:	AnaeK_0426

MRM:	A7982_01269 A7982_10481

MTU:	Rv3526(kshA) Rv3571(kshB)

MTV:	RVBD_3526 RVBD_3571

MTC:

MT3676

MRA:	MRA_3565 MRA_3610(hmp)

MTF:	TBFG_13559 TBFG_13604

MTB:	TBMG_03565 TBMG_03610

MTK:	TBSG_03592 TBSG_03637

MTZ:	TBXG_003541 TBXG_003585

MTG:	MRGA327_21785 MRGA327_22045

MTE:	CCDC5079_3267 CCDC5079_3312

MTUR:

CFBS_3742 CFBS_3788(hmp)

MTL:	CCDC5180_3219 CCDC5180_3264

MTO:	MTCTRI2_3590 MTCTRI2_3636(hmp)

MTD:	UDA_3526 UDA_3571(hmp)

MTN:	ERDMAN_3866 ERDMAN_3918(hmp)

MTJ:	J112_18980 J112_19230

MTUB:

MT7199_3587 MT7199_3634

MTUC:

J113_24655

MTUE:

J114_18850 J114_19100

MTX:	M943_18130 M943_18365

MTUH:

I917_24735 I917_25090

MTUL:

TBHG_03466 TBHG_03512

MTUT:

HKBT1_3727 HKBT1_3773(hmp)

MTUU:

HKBT2_3736 HKBT2_3782(hmp)

MTQ:	HKBS1_3739 HKBS1_3785(hmp)

MBO:	BQ2027_MB3556(ksha) BQ2027_MB3602(kshb)

MBB:	BCG_3590 BCG_3636(hmp)

MBT:	JTY_3591 JTY_3637(hmp)

MBM:	BCGMEX_3588 BCGMEX_3634(hmp)

MBK:	K60_036610 K60_037090

MBX:	BCGT_3389 BCGT_3438

MAF:	MAF_35380 MAF_35840(hmp)

MMIC:

RN08_3901 RN08_3948

MCE:	MCAN_35371 MCAN_35841(hmp)

MCQ:	BN44_110015 BN44_110066(hmp)

MCV:	BN43_90021 BN43_90072(hmp)

MCX:	BN42_90018 BN42_90069(hmp)

MCZ:	BN45_100018 BN45_100085(hmp)

MORY:

MO_003682(kshA) MO_003730(kshB)

MPA:	MAP_0496c MAP_1434 MAP_2377 MAP_2882c

MAO:	MAP4_0925 MAP4_1446 MAP4_2411 MAP4_3328 MAP4_3371

MAVI:

RC58_04545 RC58_07170 RC58_11985 RC58_16505 RC58_16720

MAVU:

RE97_04545 RE97_07170 RE97_11995 RE97_16540 RE97_16755

MAV:	MAV_0590 MAV_0633 MAV_1603 MAV_1857 MAV_3037 MAV_3666

MIT:	OCO_04980 OCO_05430 OCO_28760 OCO_34910 OCO_37890

MIA:	OCU_05020 OCU_05470 OCU_28620 OCU_34960 OCU_37970

MID:	MIP_00939 MIP_00998 MIP_03683 MIP_05257 MIP_05742

MYO:	OEM_05040 OEM_05500 OEM_27250 OEM_35350 OEM_38530

MCHI:

AN480_02490 AN480_02715 AN480_15050 AN480_18495 AN480_19995

MIR:	OCQ_05140 OCQ_05580 OCQ_27340 OCQ_36130 OCQ_39120

MMAL:

CKJ54_02420 CKJ54_02640 CKJ54_13075 CKJ54_16420 CKJ54_18030

MLP:	MLM_0734 MLM_0777

MMAN:

MMAN_03030 MMAN_10160 MMAN_41010 MMAN_41330 MMAN_47930(hmp) MMAN_48390(kshA)

MSA:	Mycsm_04176 Mycsm_04590 Mycsm_05671 Mycsm_05761 Mycsm_05841

MUL:	MUL_2161 MUL_4089 MUL_4142(hmp)

MMI:	MMAR_1935 MMAR_5015 MMAR_5066(hmp)

MMAE:

MMARE11_18630 MMARE11_48250 MMARE11_48810(hmp)

MLI:	MULP_02106 MULP_05266 MULP_05324(hmp)

MPSE:

MPSD_19540 MPSD_52140(kshA) MPSD_52670(hmp)

MSHO:

MSHO_04870(kshA) MSHO_05500(hmp) MSHO_52600

MMC:	Mmcs_0296 Mmcs_0319 Mmcs_1788 Mmcs_3569 Mmcs_3712 Mmcs_4640 Mmcs_4710

MKM:	Mkms_0306 Mkms_0329 Mkms_1835 Mkms_3642 Mkms_3785 Mkms_4728 Mkms_4796

MJL:	Mjls_0287 Mjls_0310 Mjls_1769 Mjls_3574 Mjls_3725 Mjls_4115 Mjls_5022 Mjls_5095

MMM:	W7S_02435 W7S_02660 W7S_13945 W7S_17465 W7S_18975

MKN:	MKAN_11805 MKAN_12135 MKAN_24985

MYV:	G155_01230 G155_03705 G155_04100 G155_04260 G155_04755 G155_07820 G155_09255 G155_10850 G155_24375 G155_26490

MYE:	AB431_00270 AB431_11155 AB431_15090 AB431_17425 AB431_24925 AB431_26315 AB431_26560

MHAD:

B586_04440 B586_04665

MDX:	BTO20_04370 BTO20_24105 BTO20_26115 BTO20_31150 BTO20_33265

MSHG:

MSG_00805(kshA_1) MSG_01415 MSG_01753 MSG_02466 MSG_04513(kshA_2) MSG_04564(hmp)

MFJ:	MFLOJ_08010 MFLOJ_15040 MFLOJ_37900 MFLOJ_40640(hmp) MFLOJ_41090(kshA)

MSTO:

MSTO_09240 MSTO_16460 MSTO_41650 MSTO_44590(hmp) MSTO_45060(kshA)

MSIM:

MSIM_05770 MSIM_29080(hmp) MSIM_29510 MSIM_53050

MSAK:

MSAS_01950 MSAS_05490 MSAS_28680(kshA) MSAS_29180(hmp) MSAS_55210

MKU:	I2456_13035 I2456_25455 I2456_25690

MLW:	MJO58_09530 MJO58_12925 MJO58_24865 MJO58_25105 MJO58_26420

MXE:	MYXE_05050(hmp) MYXE_06210 MYXE_09820

MNV:	MNVI_10350 MNVI_10880 MNVI_11900 MNVI_12100(kshA) MNVI_12540(hmp)

MPAG:

C0J29_08865 C0J29_19365 C0J29_22020 C0J29_27500 C0J29_27840

MNM:	MNVM_02730 MNVM_19150 MNVM_19370 MNVM_23420(hmp) MNVM_24080(kshA) MNVM_25620 MNVM_27170

MGOR:

H0P51_05885 H0P51_07835 H0P51_17940 H0P51_25550 H0P51_25880

MCOO:

MCOO_16460 MCOO_24770 MCOO_26240 MCOO_26790(kshA) MCOO_27340(hmp) MCOO_32620

MBAI:

MB901379_01756(kshA_1) MB901379_04408(kshA_3) MB901379_04455(hmp_2)

MSEO:

MSEO_05640 MSEO_08800 MSEO_12570 MSEO_34070(kshA) MSEO_34590(hmp)

MHEK:

JMUB5695_00466(hmp) JMUB5695_00520 JMUB5695_00538 JMUB5695_00733 JMUB5695_00940

MGAU:

MGALJ_04040 MGALJ_04550 MGALJ_23030 MGALJ_25620 MGALJ_30410 MGALJ_31940 MGALJ_37890(kshA) MGALJ_38590(kshB)

MLJ:	MLAC_00150(kshA_1) MLAC_47210(hmp) MLAC_47870(kshA_2)

MBRD:

MBRA_19980(hmp) MBRA_20460(kshA) MBRA_22880 MBRA_33050 MBRA_50470

MSHJ:

MSHI_38510(hmp) MSHI_39140

MMAM:

K3U93_08570 K3U93_11775 K3U93_22435 K3U93_22700

MSPG:

F6B93_00890 F6B93_12430 F6B93_20245 F6B93_20500

MOT:	LTS72_00025 LTS72_15090 LTS72_27905

MPAA:

MKK62_02380 MKK62_02645 MKK62_02840 MKK62_09895

MKY:	IWGMT90018_16290 IWGMT90018_22640 IWGMT90018_56870(kshA) IWGMT90018_57530(hmp)

MADI:

A7U43_00470 A7U43_06650 A7U43_07045 A7U43_23205

MWU:	PT015_07635 PT015_14380 PT015_15120 PT015_15320 PT015_15575

MSM:	MSMEG_0734 MSMEG_2870 MSMEG_2893 MSMEG_5925 MSMEG_6039

MSG:	MSMEI_2796 MSMEI_2819(hmp) MSMEI_5766 MSMEI_5878(hmp)

MSB:	LJ00_14275 LJ00_14390 LJ00_29300 LJ00_29855

MSN:	LI99_14280 LI99_14395 LI99_29305 LI99_29860

MSH:	LI98_14285 LI98_14400 LI98_29310 LI98_29865

MVA:	Mvan_2012 Mvan_2869 Mvan_2893 Mvan_4186 Mvan_5211 Mvan_5225 Mvan_5309

MGI:	Mflv_1462 Mflv_1533 Mflv_1546 Mflv_2468 Mflv_4333 Mflv_4566

MSP:	Mspyr1_09170 Mspyr1_09300 Mspyr1_18940 Mspyr1_21920 Mspyr1_36780 Mspyr1_39660 Mspyr1_47050

MCB:	Mycch_1569 Mycch_1592 Mycch_1754 Mycch_3303 Mycch_3622 Mycch_4570 Mycch_4587 Mycch_4676

MNE:	D174_08275 D174_24200 D174_24715

MYN:	MyAD_08130 MyAD_21895 MyAD_23740 MyAD_24250

MFT:	XA26_02660 XA26_06910 XA26_07730 XA26_08090 XA26_09130 XA26_15580 XA26_18510 XA26_22320 XA26_49330 XA26_53640

MPHL:

MPHLCCUG_00490(hmp_1) MPHLCCUG_00577(kshA_1) MPHLCCUG_00595(kshA_2) MPHLCCUG_01870(kshA_3) MPHLCCUG_01926(kshA_4) MPHLCCUG_02604(kshA_6) MPHLCCUG_03747(hmp_4)

MVQ:	MYVA_1646 MYVA_1666(kshB) MYVA_1911 MYVA_3602 MYVA_3985 MYVA_5096(kshA) MYVA_5113 MYVA_5219

MLL:	B1R94_00400 B1R94_14190 B1R94_20075 B1R94_20210 B1R94_20780 B1R94_24935 B1R94_25475

MRH:	MycrhN_2242 MycrhN_2306 MycrhN_3476 MycrhN_4240 MycrhN_6043 MycrhN_6097

MTHN:

4412656_00372(kshA_2) 4412656_00943(kshA_4) 4412656_00961(hmp_2) 4412656_01450(kshA_5) 4412656_03040(hmp_3) 4412656_03259(kshA_6) 4412656_04042(kshA_8) 4412656_04095(hmp_6)

MHAS:

MHAS_00793(kshA_2) MHAS_00844(kshA_3) MHAS_02479(kshA_4) MHAS_02573(kshB) MHAS_03041(kshA_5) MHAS_03182(kshA_7) MHAS_03697(kshA_8) MHAS_03711(kshA_9) MHAS_03780(hmp)

MDU:	MDUV_04890 MDUV_07840 MDUV_19840 MDUV_19850 MDUV_19890 MDUV_24890 MDUV_26640 MDUV_26870 MDUV_31180 MDUV_31190 MDUV_48980(kshB) MDUV_49830(kshA) MDUV_49950

MCHT:

MCHIJ_12540 MCHIJ_12740 MCHIJ_12900 MCHIJ_19280(kshB) MCHIJ_20060(kshA) MCHIJ_21220 MCHIJ_47580

MAUU:

NCTC10437_01869(kshA_1) NCTC10437_02719(kshA_2) NCTC10437_02741(hmp_2) NCTC10437_03541(kshA_3) NCTC10437_03926(hmp_3) NCTC10437_04973(kshA_5) NCTC10437_04990(kshA_6) NCTC10437_05070(hmp_5)

MMAG:

MMAD_02700 MMAD_47870(kshA) MMAD_48600(kshB)

MMOR:

MMOR_10320 MMOR_11730(kshB) MMOR_12370(kshA) MMOR_26640 MMOR_44820 MMOR_45300

MFX:	MFAL_16460 MFAL_27870(kshA_1) MFAL_32570(kshB) MFAL_33700(kshA_2) MFAL_34890

MAIC:

MAIC_05160(hmp) MAIC_05860(kshA) MAIC_07830 MAIC_26600 MAIC_30570 MAIC_56030

MIJ:	MINS_00070(kshA_1) MINS_00720(kshB) MINS_06060 MINS_18900 MINS_42010 MINS_43000 MINS_43130(kshA_2)

MALV:

MALV_16800 MALV_19850 MALV_21750 MALV_29210 MALV_29530 MALV_30220 MALV_33090 MALV_42110(kshB) MALV_42940(kshA) MALV_46370

MTY:	MTOK_21970(kshB) MTOK_23000(kshA) MTOK_23190 MTOK_60760

MPSC:

MPSYJ_15740(kshB) MPSYJ_16390(kshA) MPSYJ_16560 MPSYJ_29890

MARZ:

MARA_20680 MARA_32980 MARA_47410(kshB) MARA_48540(kshA)

MGAD:

MGAD_00940 MGAD_19550 MGAD_20060 MGAD_30280 MGAD_36970(kshA) MGAD_37710(kshB) MGAD_56920

MHEV:

MHEL_21480 MHEL_27620(hmp) MHEL_28320(kshA) MHEL_44410 MHEL_49770 MHEL_50140

MSAR:

MSAR_10460(kshA) MSAR_11000(hmp) MSAR_16650 MSAR_32120 MSAR_41460

MANY:

MANY_15950 MANY_32520(kshA) MANY_33070(hmp) MANY_33930 MANY_37610

MAUB:

MAUB_13170 MAUB_13780 MAUB_26190(kshA) MAUB_27110(kshB) MAUB_35870 MAUB_38560 MAUB_51360 MAUB_54660

MPOF:

MPOR_23460 MPOR_39600 MPOR_53110 MPOR_53290(kshA) MPOR_54020(kshB)

MPHU:

MPHO_14510 MPHO_31660 MPHO_34400 MPHO_43350(kshB) MPHO_44160(kshA_1) MPHO_45360 MPHO_55450(kshA_2)

MMUC:

C1S78_000955 C1S78_002100 C1S78_009420 C1S78_011035 C1S78_018450 C1S78_019240 C1S78_019360 C1S78_019890 C1S78_024600 C1S78_025205 C1S78_025625

MMAT:

MMAGJ_15440 MMAGJ_33750(kshB) MMAGJ_34960(kshA) MMAGJ_47430

MBOK:

MBOE_03820(kshA) MBOE_04990(kshB) MBOE_18780 MBOE_19670 MBOE_20130 MBOE_42950 MBOE_56150 MBOE_59170 MBOE_60810

MFG:	K6L26_05330 K6L26_05780 K6L26_16780 K6L26_23275 K6L26_27675 K6L26_27820 K6L26_28195

MSEI:

MSEDJ_01820(kshA) MSEDJ_02540(kshB) MSEDJ_18360

MFLV:

NCTC10271_00464(hmp_1) NCTC10271_00524(kshA_1) NCTC10271_02165(kshA_2) NCTC10271_03524(kshA_5) NCTC10271_03628(kshA_6)

MCEE:

MCEL_05830 MCEL_17550 MCEL_18020 MCEL_37710(kshB) MCEL_38400(kshA)

MMON:

EWR22_01585 EWR22_01700 EWR22_18415 EWR22_19145 EWR22_21125 EWR22_21130 EWR22_25090 EWR22_25475

MGO:	AFA91_10575 AFA91_11130

MHOL:

K3U96_03065 K3U96_03360 K3U96_09525 K3U96_17790 K3U96_18060

MSEN:

K3U95_03580 K3U95_09605 K3U95_12885 K3U95_20520 K3U95_25050 K3U95_25525

MPAE:

K0O64_00245 K0O64_10800 K0O64_14540 K0O64_20470 K0O64_24620 K0O64_25805 K0O64_26070

MRF:	MJO55_17045 MJO55_23770 MJO55_23860 MJO55_24190

MDF:	K0O62_02770 K0O62_15775 K0O62_15940 K0O62_25360 K0O62_25980

MCRO:

MI149_00375 MI149_11665 MI149_15395 MI149_15520 MI149_21050 MI149_25025 MI149_26115 MI149_26370

MGRO:

FZ046_02575 FZ046_02955 FZ046_08935

MKR:	MKOR_24880 MKOR_35310(hmp) MKOR_35890(kshA) MKOR_36630

MPAK:

MIU77_01960 MIU77_02235

MAB:	MAB_0080c MAB_0583c MAB_0726 MAB_4173

MMV:	MYCMA_0050 MYCMA_1991 MYCMA_2177 MYCMA_2322

MABB:

MASS_0082 MASS_0552 MASS_3633 MASS_3931 MASS_4172

MABL:

MMASJCM_0083 MMASJCM_0572 MMASJCM_3622 MMASJCM_3937 MMASJCM_4259

MCHE:

BB28_00390 BB28_02780 BB28_18525 BB28_20180 BB28_21490 BB28_22430

MIZ:	BAB75_00690 BAB75_03530 BAB75_20635 BAB75_22365 BAB75_23955

MSTE:

MSTE_00075 MSTE_00540 MSTE_03759 MSTE_04090 MSTE_04349 MSTE_04547

MSAO:

MYCSP_02485 MYCSP_15855 MYCSP_16680 MYCSP_18190 MYCSP_19530 MYCSP_20445

MSAL:

DSM43276_00501(hmp_1) DSM43276_00643(kshA_1) DSM43276_03419(kshA_2) DSM43276_03727(hmp_4) DSM43276_04014(kshA_3)

MJD:	JDM601_1615 JDM601_3357 JDM601_3518(hmp) JDM601_3668 JDM601_3855(hmp) JDM601_4248(hmp) JDM601_4270

MTER:

4434518_01527(kshA_1) 4434518_03344(kshA_2) 4434518_03494(hmp_1) 4434518_03640(kshA_3) 4434518_03730(hmp_2)

MMIN:

MMIN_06680 MMIN_06920 MMIN_11900(kshA) MMIN_12550(hmp) MMIN_32160

MHIB:

MHIB_10560 MHIB_23820 MHIB_24030 MHIB_27800 MHIB_29150 MHIB_30580(kshA) MHIB_31190(hmp)

MHER:

K3U94_08890 K3U94_19910 K3U94_20720 K3U94_21035

MVM:	MJO54_08985 MJO54_19815 MJO54_20640 MJO54_20930

ASD:	AS9A_0920 AS9A_0922(kshA) AS9A_2419

NFA:	NFA_22480 NFA_33560 NFA_33740 NFA_40990 NFA_4750 NFA_50680

NFR:	ERS450000_00679(kshA_1) ERS450000_00697(kshA_2) ERS450000_01849(kshA_3) ERS450000_02931(kshA_4) ERS450000_03761(kshA_5) ERS450000_04823(hmp_4) ERS450000_05814(hmp_5)

NCY:	NOCYR_0504 NOCYR_1557 NOCYR_2402 NOCYR_2420(ksh) NOCYR_2512 NOCYR_4851

NBR:	O3I_002680 O3I_006885 O3I_038125

NNO:	NONO_c05000 NONO_c21270 NONO_c33260 NONO_c36770 NONO_c43500 NONO_c44660 NONO_c51650(kshB1) NONO_c58770(kshB2) NONO_c58790(kshA) NONO_c68680

NSL:	BOX37_02190 BOX37_11740 BOX37_11865 BOX37_15565 BOX37_18490 BOX37_27470 BOX37_29000

NSR:	NS506_01263(kshA) NS506_02682 NS506_04325 NS506_06286 NS506_06779 NS506_06781 NS506_07836

NTP:	CRH09_03320 CRH09_36350

NOZ:	DMB37_16935 DMB37_23605 DMB37_40335

NOD:	FOH10_00665 FOH10_14610 FOH10_16055 FOH10_20585 FOH10_22600 FOH10_22610 FOH10_28730

NAH:	F5544_02645 F5544_20855 F5544_40650

NAD:	NCTC11293_01248(kshA_1) NCTC11293_04392(kshA_2) NCTC11293_04411(hmp_1) NCTC11293_04696(hmp_2) NCTC11293_06443(hmp_4)

NWL:	NWFMUON74_04960 NWFMUON74_14510 NWFMUON74_16510 NWFMUON74_27890 NWFMUON74_64550

NIE:	KV110_03040 KV110_07440 KV110_37315

NTC:	KHQ06_03660 KHQ06_09230 KHQ06_09790 KHQ06_26970 KHQ06_27550 KHQ06_35115 KHQ06_35125 KHQ06_37475

NHU:	H0264_03865 H0264_09095 H0264_13430 H0264_27825 H0264_31525 H0264_34225 H0264_34235

NYA:	LTV02_02155 LTV02_08320 LTV02_23905 LTV02_28875 LTV02_36570 LTV02_38685 LTV02_38695

NGP:	LTT66_15435 LTT66_16795 LTT66_21200 LTT66_28755 LTT66_28765 LTT66_30525

NSPU:

IFM12276_01710 IFM12276_04420 IFM12276_28680 IFM12276_30800 IFM12276_30810 IFM12276_31080

NYU:	D7D52_04510 D7D52_06440 D7D52_07030 D7D52_09485 D7D52_09495 D7D52_10835 D7D52_14120 D7D52_24780 D7D52_29640

RHA:	RHA1_ro02490 RHA1_ro04538(kshA) RHA1_ro05811 RHA1_ro05833(kshB) RHA1_ro06056 RHA1_ro09002(kshB) RHA1_ro09003(kshA)

RER:	RER_07540(kshA) RER_09150(kshA2) RER_13800(kshA) RER_17750(kshB) RER_51130(kshA)

REY:	O5Y_03665 O5Y_04070 O5Y_06500 O5Y_08515 O5Y_18435 O5Y_24235

REB:	XU06_03905 XU06_04315 XU06_06760 XU06_08755 XU06_24655

RQI:	C1M55_04145 C1M55_04545 C1M55_07005 C1M55_08985 C1M55_25820

ROP:	ROP_22170(kshA) ROP_44530(kshA) ROP_58730(kshA2) ROP_58950(kshB) ROP_61150(kshB)

ROA:	Pd630_LPD00990 Pd630_LPD02435 Pd630_LPD02458 Pd630_LPD02696 Pd630_LPD06716

RPY:	Y013_08850 Y013_19020 Y013_19240 Y013_19255

RBY:	CEJ39_05385 CEJ39_05605 CEJ39_05620 CEJ39_19740 CEJ39_21920

RHB:

NY08_2915

RAV:	AAT18_03960 AAT18_18675 AAT18_21250 AAT18_21975

RFA:	A3L23_01127(hmp_2)

RHS:	A3Q41_00422(hmp_1) A3Q41_02260(hmp_2)

RHW:	BFN03_03160 BFN03_15205

RRZ:	CS378_08145 CS378_10105 CS378_10555 CS378_11435 CS378_19600

RHQ:	IM25_00690 IM25_02790 IM25_08870

RHOD:

AOT96_05570 AOT96_14540 AOT96_14950 AOT96_17400 AOT96_19355

RRT:	4535765_00581(kshA_1) 4535765_00622(kshA_2) 4535765_00625(kshB_1) 4535765_03583(hmp_2) 4535765_04053(kshA_4) 4535765_04385(kshB_2)

RCR:	NCTC10994_02095(kshB_1) NCTC10994_02098(kshA_1) NCTC10994_02139(kshA_2) NCTC10994_02986(kshB_2) NCTC10994_03234(kshA_3) NCTC10994_03286(kshA_4) NCTC10994_03312(kshA_5) NCTC10994_03677(hmp_2)

RTM:	G4H71_04465 G4H71_04560 G4H71_07400 G4H71_13750 G4H71_16250

RKO:	JWS14_13070 JWS14_20720 JWS14_24480 JWS14_31790 JWS14_31900 JWS14_33035

RGO:	KYT97_09650 KYT97_11690 KYT97_12275 KYT97_15615 KYT97_16665 KYT97_18410 KYT97_23230

ROZ:	CBI38_00920 CBI38_01305 CBI38_01320 CBI38_04165 CBI38_04885 CBI38_20480

RPSK:

JWS13_10920 JWS13_12010 JWS13_12120 JWS13_20445 JWS13_24105 JWS13_32815

RGOR:

NMQ04_02510 NMQ04_02715 NMQ04_02730 NMQ04_15605 NMQ04_17470 NMQ04_17870

RHOP:

D8W71_01860 D8W71_07945 D8W71_08085 D8W71_12555 D8W71_26920

REQ:	REQ_06790 REQ_08980(kshA) REQ_15470 REQ_36320 REQ_40110 REQ_42740 REQ_43730 REQ_45190

PDEF:

P9209_04770 P9209_10125 P9209_27805 P9209_29080

WHR:	OG579_02805 OG579_07530 OG579_14775 OG579_17630

GBR:	Gbro_0320 Gbro_0919 Gbro_3782 Gbro_4325

GPO:	GPOL_c00590 GPOL_c36520 GPOL_c41100(kshA1) GPOL_c41200(kshA2) GPOL_c41340 GPOL_c46160

GOR:	KTR9_0819(kshA) KTR9_3740(kshB) KTR9_4196 KTR9_5394

GOQ:	ACH46_03115 ACH46_03235 ACH46_15935

GTA:	BCM27_00520 BCM27_04760 BCM27_04885 BCM27_05105 BCM27_19590 BCM27_22040 BCM27_22340

GOC:	CXX93_06455 CXX93_06935

GIT:	C6V83_04270 C6V83_16235

GRU:	GCWB2_04170(kshA1) GCWB2_11625(kshA2) GCWB2_19200(hmp6) GCWB2_21220(hmp7) GCWB2_21605(kshA4)

GOM:	D7316_02031(kshA_1) D7316_02407(hmp_2) D7316_02456(kshA_2) D7316_02565(kshA_3) D7316_02584(kshB_1) D7316_03108(kshA_4) D7316_04922(kshB_2)

GAV:	C5O27_00865 C5O27_06840 C5O27_07040 C5O27_08940 C5O27_10695 C5O27_10760 C5O27_16275

GOD:	GKZ92_00215 GKZ92_03965 GKZ92_16370 GKZ92_16435 GKZ92_18130 GKZ92_19660 GKZ92_20570

GAM:	GII34_03585 GII34_04990 GII34_18075 GII34_18815 GII34_19625

GPD:	GII33_03230 GII33_03925 GII33_04450 GII33_17530 GII33_19165 GII33_21770 GII33_21775

GJI:	H1R19_03895 H1R19_04045 H1R19_12650 H1R19_12715 H1R19_17950 H1R19_20600

GOI:	LK459_05090 LK459_05150 LK459_06945 LK459_09025 LK459_15780

GHN:	MVF96_00500 MVF96_04245 MVF96_18515 MVF96_21255

GAMI:

IHQ52_00755 IHQ52_01025 IHQ52_06825 IHQ52_07705 IHQ52_22105

GMG:	NWF22_03565 NWF22_12205 NWF22_14795 NWF22_14805 NWF22_15750

GSI:	P5P27_15305 P5P27_15795

SPIN:

KV203_03665 KV203_13540 KV203_17355

TPR:	Tpau_3447 Tpau_3517 Tpau_3849 Tpau_3851

TSM:	ASU32_19920 ASU32_20040 ASU32_21925 ASU32_21935

TPUL:

TPB0596_37600(kshB) TPB0596_38260 TPB0596_41900 TPB0596_41920

TSD:	MTP03_13380(kshB) MTP03_39520(hmp) MTP03_43350 MTP03_43370

SRT:

Srot_0411

DTM:	BJL86_0694 BJL86_0697

DIT:	C3V38_09250 C3V38_09260

DIZ:	CT688_03170 CT688_03180

DPC:	A6048_03115 A6048_03125 A6048_14145

DLU:	A6035_03410 A6035_03420

DKN:	NHB83_02960 NHB83_02970

TOY:	FO059_00150 FO059_01345 FO059_05540 FO059_14015 FO059_14025 FO059_16350 FO059_17440 FO059_17470

SGRF:

SGFS_096040

SVT:	SVTN_35870 SVTN_35880

SLD:

T261_3457

SRW:	TUE45_04033(hmp_3)

SALU:

DC74_7441 DC74_7443

SALL:

SAZ_38410 SAZ_38420

SPLU:

LK06_026215

SLX:	SLAV_27410(kshA) SLAV_27420(hmp4)

SNK:	CP967_03265 CP967_03300

SVR:	CP971_15305

SGX:	H4W23_38505 H4W23_38515

SXN:	IAG42_03495 IAG42_26625 IAG42_26635

SRUG:

F0345_00790 F0345_00825

STAA:

LDH80_36365 LDH80_36375

SNIG:

HEK616_31380 HEK616_31400

STUB:

MMF93_22435 MMF93_31665 MMF93_31800

SLON:

LGI35_13860 LGI35_13870

LXY:	O159_24870

MRN:	K8F61_04970 K8F61_04990

ARL:	AFL94_16990 AFL94_17000 AFL94_17140

ARY:	ATC04_01230 ATC04_01245 ATC04_01315

ASUN:

KG104_04210 KG104_04220

GPR:	JQN66_16875 JQN66_16945 JQN66_16955

PAEY:

KUF55_17910 KUF55_17955 KUF55_17965

LMOI:

VV02_06590

JTE:	ASJ30_13635 ASJ30_13640

NCA:	Noca_2518 Noca_2520

NDK:	I601_0574(kshA_1) I601_3442(hmp_2) I601_3444(kshA_2)

NOY:	EXE57_01175

NBE:	Back2_27910 Back2_27930

NANO:

G5V58_10115 G5V58_10125

NARO:

CFH99_05075 CFH99_13240 CFH99_13250

NPI:	G7071_12480 G7071_12670 G7071_15685 G7071_15695

NRO:	K8W59_09520

NPC:	KUV85_04490 KUV85_04500 KUV85_12205

NMAR:

HPC71_08845 HPC71_09745 HPC71_09755

NFC:	KG111_07185 KG111_08645 KG111_08655 KG111_15355 KG111_15415

PSIM:

KR76_14160 KR76_14170 KR76_18045 KR76_27070 KR76_27080

AEB:	C6I20_03500 C6I20_03510

NBT:	KLP28_00550

TCU:	Tcur_3509 Tcur_3520

ACTW:

F7P10_03565 F7P10_14665 F7P10_28350 F7P10_28445 F7P10_38145

AMAZ:

LUW76_36055 LUW76_36145

ACIR:

OG979_26430 OG979_26490

ACTQ:

OG417_40225 OG417_40270

MHAI:

OHB01_03325

FRE:	Franean1_2973 Franean1_3372 Franean1_4306

FAL:

FRAAL3502

FSY:	FsymDg_0014

FRI:	FraEuI1c_4270 FraEuI1c_5408

SVI:	Svir_18640

AMD:	AMED_2517 AMED_2519

AMN:	RAM_12795 RAM_12805

AMM:	AMES_2489 AMES_2491

AMZ:	B737_2490 B737_2492

AOI:	AORI_2479 AORI_2481

AJA:	AJAP_26420(kshA) AJAP_26430(kshB)

AMQ:	AMETH_4841 AMETH_4843

AMYC:

CU254_10435 CU254_10445 CU254_23465 CU254_23475

AMYB:

BKN51_04995 BKN51_05005

AAB:	A4R43_16060 A4R43_16070

AMYY:

YIM_14425(hmp1) YIM_14435(kshA1) YIM_36730(hmp4) YIM_36740(kshA2)

AORI:

SD37_13460 SD37_13470

AACD:

LWP59_17310 LWP59_23965 LWP59_29215 LWP59_29225

APRT:

MUY14_23845 MUY14_23855

AROO:

NQK81_09945 NQK81_09955

ATHM:

L1857_26980 L1857_26990

ARHD:

VSH64_01755 VSH64_01765

KAL:	KALB_5125 KALB_5127

KUT:	JJ691_08300 JJ691_08320

KPHY:

AOZ06_42845 AOZ06_42855

LED:	BBK82_38955 BBK82_38965

ALO:	CRK57807 CRK57817 CRK59604 CRK59606

PMAD:

BAY61_10930 BAY61_10940

SACE:

GIY23_13370 GIY23_13380

ACTU:

Actkin_05403(hmp_2)

CROS:

N8J89_29405 N8J89_29415

STP:	Strop_2672 Strop_2674

SAQ:	Sare_2880 Sare_2882

AMS:	AMIS_19150 AMIS_19170

AIH:	Aiant_18900 Aiant_18920(hmp)

ACTL:

L3i22_084480 L3i22_084500

ASIC:

Q0Z83_065600 Q0Z83_065620

AOU:	ACTOB_004116 ACTOB_004118

JCY:	M6B22_17695 M6B22_17725 M6B22_21595

AQZ:	KSP35_09030

IAM:	HC251_17785

DHI:	LH044_09460 LH044_11415

PSL:

Psta_0972

GMR:	GmarT_59890(ndoA)

CFIL:

MYF79_01955

MGOT:

MgSA37_00351(hmp)

MGIN:

FRZ54_02620

MSAB:

SNE25_05505

SRHO:

HH216_04920

DPF:	ON006_19175

RUP:	DTQ70_25235

FAE:	FAES_0794(paaE)

HYG:	AUC43_05755

HBN:	GUY19_11450

PACT:

CA264_03205

RTI:	DC20_21170

TAJ:	C1A40_00410

HALX:

M0R89_10990

HAXZ:

M0R88_11450

SAIM:

K0C01_00010

» show all

Reference

1 [PMID:19561185]

Authors

Petrusma M, Dijkhuizen L, van der Geize R

Title

Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity.

Journal

Appl Environ Microbiol 75:5300-7 (2009)
DOI:10.1128/AEM.00066-09

Sequence

[rhq:IM25_02790 IM25_00690]

Reference

2 [PMID:19234303]

Authors

Capyk JK, D'Angelo I, Strynadka NC, Eltis LD

Title

Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis.

Journal

J Biol Chem 284:9937-46 (2009)
DOI:10.1074/jbc.M900719200

Sequence

[mtu:Rv3526 Rv3571]

Reference

3 [PMID:21987574]

Authors

Capyk JK, Casabon I, Gruninger R, Strynadka NC, Eltis LD

Title

Activity of 3-ketosteroid 9alpha-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis.

Journal

J Biol Chem 286:40717-24 (2011)
DOI:10.1074/jbc.M111.289975

Other DBs

ExplorEnz - The Enzyme Database:

1.14.15.30

IUBMB Enzyme Nomenclature:

1.14.15.30

ExPASy - ENZYME nomenclature database:

1.14.15.30

BRENDA, the Enzyme Database:

1.14.15.30

DBGET integrated database retrieval system