KEGG   ENZYME: 1.14.19.15
Entry
EC 1.14.19.15               Enzyme                                 
Name
(11Z)-hexadec-11-enoyl-CoA conjugase;
Bmpgdesat1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
(11Z)-hexadec-11-enoyl-CoA,reduced acceptor:oxygen 10,13-allylic oxidase (10E,12E-forming)
Reaction(IUBMB)
(11Z)-hexadec-11-enoyl-CoA + reduced acceptor + O2 = (10E,12Z)-hexadeca-10,12-dienoyl-CoA + acceptor + 2 H2O [RN:R11004]
Reaction(KEGG)
R11004
Substrate
(11Z)-hexadec-11-enoyl-CoA [CPD:C20998];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
(10E,12Z)-hexadeca-10,12-dienoyl-CoA [CPD:C20999];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the silk moth Bombyx mori, catalyses a step in the pathway for the biosynthesis of bombykol, a sex pheromone produced by the moth. The enzyme converts a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds. Prior to catalysing this reaction, the enzyme catalyses the introduction of the cis bond in position 11 (cf. EC 1.14.19.5, acyl-CoA 11-desaturase).
History
EC 1.14.19.15 created 2015
Orthology
K21709  (11Z)-hexadec-11-enoyl-CoA conjugase
Genes
BMOR692567(Desat1)
BMAN114252499
MSEX115441956 115441957 115446447 115449837 115449839 115451799 115455164 119189790 119189823
BANY112044021 112044025 112050800 112050801 112050802 128199563
MJU123864349 123877338 123877339 123877340 123877341 123878762 123878764
NIQ126779609
VCD124541435
MCIX123667011 123667012 123667014 123667015 123667016 123667113
PPOT106103918 106107071
PXU106115230 106115777 106115783
PRAP110995605 110995612 110995613 110999987 111000744 123689588 123689607 123690040
PBX123707398 123708018 123708035 123711759 123718119
PNAP125048490 125048491 125048492 125055873 125058767 125063417 125063797
CCRC123702365
LSIN126973268 126973630 126973631 126973633
HZE124633820 124644155
SLIU111357437
OFU114352825 114352833 114353661 114363109 114363117
PGW126366314 126366637 126375543 126375906 126375907
 » show all
Reference
1  [PMID:15173596]
  Authors
Moto K, Suzuki MG, Hull JJ, Kurata R, Takahashi S, Yamamoto M, Okano K, Imai K, Ando T, Matsumoto S
  Title
Involvement of a bifunctional fatty-acyl desaturase in the biosynthesis of the silkmoth, Bombyx mori, sex pheromone.
  Journal
Proc Natl Acad Sci U S A 101:8631-6 (2004)
DOI:10.1073/pnas.0402056101
  Sequence
[bmor:692567]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.15
IUBMB Enzyme Nomenclature: 1.14.19.15
ExPASy - ENZYME nomenclature database: 1.14.19.15
BRENDA, the Enzyme Database: 1.14.19.15

DBGET integrated database retrieval system