KEGG ENZYME: 1.14.19.24

ENZYME: 1.14.19.24

Entry

EC 1.14.19.24               Enzyme

Name

acyl-CoA 11-(E)-desaturase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Sysname

acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (11,12 trans-dehydrogenating)

Reaction(IUBMB)

an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11E)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O

Substrate

acyl-CoA [CPD:C00040];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]

Product

(11E)-enoyl-CoA;
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]

Comment

Involved in sex pheromone synthesis in the Lepidoptera (moths). The enzyme from the moth Spodoptera littoralis prefers 13:0 and 14:0 substrates. The product is formed by the stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. cf. EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase.

History

EC 1.14.19.24 created 2000 as EC 1.14.99.31, transferred 2015 to EC 1.14.19.24

Reference

Authors

Foster, S. P. and Roelofs, W. L.

Title

Biosynthesis of a monoene and a conjugated diene sex pheromone component of the lightbrown apple moth by 11 desaturation.

Journal

Experientia 46:269-273 (1990)

Reference

2 [PMID:2295634]

Authors

Martinez T, Fabrias G, Camps F

Title

Sex pheromone biosynthetic pathway in Spodoptera littoralis and its activation by a neurohormone.

Journal

J Biol Chem 265:1381-7 (1990)

Reference

Authors

Navarro, I., Font, I., Fabrias, G. and Camps, F.

Title

Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone.

Journal

J Am Chem Soc 119:11335-11336 (1997)

Reference

4 [PMID:10563812]

Authors

Pinilla A, Camps F, Fabrias G

Title

Cryptoregiochemistry of the delta11-myristoyl-CoA desaturase involved in the biosynthesis of Spodoptera littoralis sex pheromone.

Journal

Biochemistry 38:15272-7 (1999)
DOI:10.1021/bi990972n

Other DBs

ExplorEnz - The Enzyme Database:

1.14.19.24

IUBMB Enzyme Nomenclature:

1.14.19.24

ExPASy - ENZYME nomenclature database:

1.14.19.24

BRENDA, the Enzyme Database:

1.14.19.24

CAS:	199543-17-4

All links

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