KEGG ENZYME: 1.14.19.3

ENZYME: 1.14.19.3

Entry

EC 1.14.19.3                Enzyme

Name

acyl-CoA 6-desaturase;
Delta6-desaturase;
Delta6-fatty acyl-CoA desaturase;
Delta6-acyl CoA desaturase;
fatty acid Delta6-desaturase;
fatty acid 6-desaturase;
linoleate desaturase;
linoleic desaturase;
linoleic acid desaturase;
linoleoyl CoA desaturase;
linoleoyl-coenzyme A desaturase;
long-chain fatty acid Delta6-desaturase;
linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase;
linoleoyl-CoA desaturase;
FADS2 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Sysname

acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)

Reaction(IUBMB)

(1) linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R03814];
(2) alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R07933]

Reaction(KEGG)

R03814 R07933;
(other) R07063 R11110 R11111 R12167 R12168 R12170 R12171 R12172

Substrate

linoleoyl-CoA [CPD:C02050];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080];
alpha-linolenoyl-CoA [CPD:C16162]

Product

gamma-linolenoyl-CoA [CPD:C03035];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001];
stearidonoyl-CoA [CPD:C16163]

Comment

An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA [4], and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate [3]. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase.

History

EC 1.14.19.3 created 1986 as EC 1.14.99.25, transferred 2000 to EC 1.14.19.3, modified 2015

Pathway

ec00591

Linoleic acid metabolism

ec01040

Biosynthesis of unsaturated fatty acids

ec01100

Metabolic pathways

Orthology

K00508

linoleoyl-CoA desaturase

K10226

acyl-CoA 6-desaturase (Delta-6 desaturase)

Genes

HSA:	9415(FADS2)

PTR:	451244(FADS2)

PPS:	100980611(FADS2)

GGO:	109024898(FADS2)

PON:	100190814(FADS2)

NLE:	100596455(FADS2)

HMH:	116468868(FADS2)

MCC:	719037(FADS2)

MCF:	101926688(FADS2)

MTHB:

126935474

MNI:	105469424(FADS2)

CSAB:

103234245(FADS2)

CATY:

105577581(FADS2)

PANU:

100126749(FADS2)

TGE:	112606127(FADS2)

MLEU:

105549019(FADS2)

RRO:	104679373(FADS2)

RBB:	108533600(FADS2)

TFN:	117080261(FADS2)

PTEH:

111524318(FADS2)

CANG:

105512289(FADS2)

CJC:	100387410(FADS2)

SBQ:	101051429(FADS2)

CIMI:

108286221(FADS2)

CSYR:

103269267(FADS2)

MMUR:

105878617(FADS2)

LCAT:

123641268(FADS2)

PCOQ:

105825053(FADS2)

OGA:	100953713(FADS2)

MMU:	56473(Fads2)

MCAL:

110285898(Fads2)

MPAH:

110322460(Fads2)

RNO:	83512(Fads2)

MCOC:

116103546(Fads2)

ANU:	117707574(Fads2)

MUN:	110548092(Fads2)

CGE:	100757464(Fads2)

MAUA:

101844598(Fads2)

PROB:

127228840(Fads2)

PLEU:

114703436(Fads2)

MORG:

121453878(Fads2)

MFOT:

126498526

AAMP:

119814598(Fads2)

NGI:	103729125(Fads2)

HGL:	101726663(Fads2)

CPOC:

100724176(Fads2)

CCAN:

109695673(Fads2)

DORD:

105993195 105995277(Fads2)

DSP:	122104886(Fads2)

PLOP:

125362342(Fads2)

NCAR:

124958641

MMMA:

107160135(Fads2)

OCU:	100352712(FADS2)

OPI:	101520480(FADS2)

TUP:	102475407(FADS2)

GVR:	103604810(FADS2)

CFA:	483792(FADS2)

CLUD:

112659414(FADS2)

VVP:	112911087(FADS2)

VLG:	121472257(FADS2)

NPO:	129500992(FADS2)

AML:	100470289(FADS2)

UMR:

103678231

UAH:	113246983(FADS2)

UAR:	123785126(FADS2)

ELK:

111149586

LLV:

125078518

MPUF:

101675571(FADS2)

MNP:	132020124(FADS2)

MLK:	131813734(FADS2)

NVS:	122912990(FADS2)

ORO:	101364529(FADS2)

EJU:	114220204(FADS2)

ZCA:	113914859(FADS2)

MLX:	118015922(FADS2)

NSU:	110576322(FADS2)

LWW:

102726376

FCA:	101085071(FADS2)

PYU:	121043312(FADS2)

PCOO:

112851879(FADS2)

PBG:	122483864(FADS2)

PVIV:

125176351(FADS2)

LRUF:

124505588

PTG:	102968308(FADS2) 102969100

PPAD:

109246554(FADS2) 109261216

PUC:

125911228

AJU:	106986967 106988351

HHV:	120227477 120227525 120246152(FADS2)

BTA:	521822(FADS2)

BOM:	102275533(FADS2)

BIU:	109554370(FADS2)

BBUB:

102405983(FADS2)

BBIS:

104998707(FADS2)

CHX:	100861212 102171133(FADS2)

OAS:	101108615(FADS2)

BTAX:

128069159(FADS2)

ODA:	120874547(FADS2)

CCAD:

122431166(FADS2) 122451127

MBEZ:

129548882(FADS2) 129560310

SSC:	444997(FADS2)

CFR:	102506325(FADS2)

CBAI:

105070113(FADS2)

CDK:	105091525(FADS2) 105104977

VPC:	102535510 102543923(FADS2)

BACU:

103000252(FADS2)

BMUS:

118899178(FADS2)

LVE:	103083143(FADS2)

OOR:	101275563(FADS2)

DLE:	111183883(FADS2)

PCAD:

114487991

PSIU:

116757879(FADS2)

NASI:

112402052(FADS2)

ECB:	100062709(FADS2)

EPZ:	103543786 103567043(FADS2)

EAI:	106847560(FADS2)

MYB:	102261893(FADS2)

MYD:	102773468(FADS2)

MMYO:

118649000(FADS2)

MLF:

102433969

PKL:	118707198(FADS2)

EFUS:

103303327(FADS2)

MNA:	107527684(FADS2)

DRO:	112317237(FADS2)

SHON:

118996917(FADS2)

AJM:	119043681(FADS2)

PDIC:

114499454(FADS2)

PHAS:

123829520(FADS2)

MMF:	118627539(FADS2)

PPAM:

129062749(FADS2)

HAI:	109390019(FADS2)

RFQ:	117030358(FADS2)

PALE:

102894063(FADS2)

PGIG:

120600650(FADS2)

PVP:	105297786(FADS2)

RAY:	107501589(FADS2)

MJV:	108407763(FADS2)

TOD:	119250071(FADS2)

SARA:

101540602(FADS2)

LAV:

100677680

TMU:

101347025

ETF:	101661366(FADS2)

DNM:	101419118(FADS2)

MDO:	100009895(FADS2)

GAS:	123252763(FADS2)

SHR:	100930034(FADS2)

AFZ:

127541862

PCW:	110195307(FADS2)

OAA:

100086288

GGA:	423122(FADS2)

PCOC:

116239008(FADS2)

MGP:

100549977

CJO:	107314439(FADS2)

TPAI:

128085490

LMUT:

125695386

NMEL:

110400735(FADS2)

APLA:

101798758(FADS2)

ACYG:

106033870

CATA:

118249734(FADS2)

AFUL:

116489695(FADS2)

TGU:	100222881(FADS2)

LSR:	110484926(FADS2)

SCAN:

103822123(FADS2)

PMOA:

120499564(FADS2)

OTC:	121339150(FADS2)

PRUF:

121354750(FADS2)

GFR:	102040567(FADS2)

FAB:	101810111(FADS2)

OMA:

130253519

PHI:	102112585(FADS2)

PMAJ:

107205402

CCAE:

111930632

CCW:	104697641(FADS2)

CBRC:

103614698(FADS2)

ETL:

114067866

ZAB:

102066733

ACHL:

103799150

SVG:	106854756(FADS2)

MMEA:

130580081

HRT:

120753732

FPG:	101910606(FADS2)

FCH:	102058085(FADS2)

CLV:	102098615(FADS2)

EGZ:

104122147

NNI:	104009393(FADS2)

PCRI:

104029808

PLET:

104623342

EHS:

104504871

PCAO:

104047971

ACUN:

113481354

TALA:

104369427(FADS2)

PADL:

103925785(FADS2)

AFOR:

103905746(FADS2)

ACHC:

115352166(FADS2)

HALD:

104323730

HLE:	104829423(FADS2)

AGEN:

126046833

GCL:

127016608

CCRI:

104168591

CSTI:

104556935

CMAC:

104479690

MUI:

104535393

BREG:

104632474

FGA:

104078771

GSTE:

104261724

LDI:

104349227

MNB:

103779901

OHA:	104339401(FADS2)

NNT:

104413574

SHAB:

115606141

DPUB:

104304413(FADS2)

PGUU:

104458947

ACAR:

104523447

CPEA:

104397494(FADS2)

AVIT:

104271174

CVF:	104287520(FADS2)

RTD:	128908397(FADS2)

CUCA:

104062412(FADS2)

TEO:

104376392

BRHI:

104495821

AAM:

106490046

AROW:

112978021

NPD:	112948004(FADS2)

TGT:

104566742

DNE:	112991695(FADS2)

SCAM:

104139314(FADS2)

ASN:

102382989

AMJ:	102563693(FADS2)

CPOO:

109318131

GGN:	109295789(FADS2)

PSS:	102460236(FADS2)

CMY:

102933275

CCAY:

125639128

DCC:

119857372

CPIC:

101936434(FADS2)

TST:	117877425(FADS2)

CABI:

116830902(FADS2)

MRV:

120403580

ACS:	100551818(fads2)

ASAO:

132771965

PVT:	110086191(FADS2)

SUND:

121930482

PBI:	103050551(FADS2)

PMUR:

107300095

CTIG:

120312451

TSR:	106538426(FADS2)

PGUT:

117667019

APRI:

131184396

PTEX:

113440355

NSS:

113424551

VKO:

123021211

PMUA:

114600538

PRAF:

128417635

ZVI:

118089026

HCG:

128339343

GJA:	107108854(FADS2)

STOW:

125427058

EMC:

129324106

XLA:	399058(fads2.S) 446688(fads2.L)

XTR:	100145314(fads2)

NPR:	108794176(FADS2)

RTEM:

120917257(FADS2)

BBUF:

120981189(FADS2)

BGAR:

122920199(FADS2)

MUO:	115468974(FADS2)

GSH:	117352277(FADS2)

DRE:	140615(fads2)

SRX:

107754339

SANH:

107655157 107674834

SGH:	107551431 107561173

CCAR:

109079315 109089845 109112895

CAUA:

113042868 113043033 113060802 113066630

CGIB:

127946970 128014141

PTET:

122330662(fads2)

LROH:

127157126(fads2)

OMC:	131534870(fads2)

PPRM:

120474050(fads2)

RKG:	130106492(fads2)

MAMB:

125246733(fads2)

CIDE:

127506530

MASI:

127435798 127437192

TROS:

130551795(fads2)

TDW:	130413973(fads2)

IPU:	100305117 108275104

IFU:	128617945 128618346

PHYP:

113529790 113529791

SMEO:

124392159 124392817(fads2)

TFD:	113660036 113660090

TVC:	132856696 132857380

AMEX:

103027972(fads2)

CMAO:

118811918(fads2)

EEE:	113588191(fads2)

CHAR:

105904229(fads2)

LCO:	104937137(fads2)

NCC:	104956187(fads2)

TBEN:

117491472(fads2)

CGOB:

115010175(fads2)

PGEO:

117447932(fads2)

GACU:

117538871(fads2)

EMAC:

134878275(fads2)

ELY:	117262279(fads2)

EFO:	125887440(fads2)

PLEP:

121949837(fads2)

SLUC:

116038811 116038812

ECRA:

117949003

ESP:	116693333 116693334

PFLV:

114560045 114560046(fads2)

GAT:	120809502(fads2) 120813621 120829775

PPUG:

119195671(fads2)

AFB:	129108760(fads2)

CLUM:

117732372(fads2)

PSWI:

130195900(fads2)

MSAM:

119884848 119893991(fads2) 119914409

SCHU:

122875428(fads2)

CUD:	121515126(fads2)

ALAT:

119023767(fads2)

MZE:	101473241 101473919 101474216

ONL:	100534418(fadsd6) 100700077 100700348

OAU:	116326238 116326239 116326240

OLA:	101156321 101156571 101156814

OML:	112139866 112151777 112151778

CSAI:

133444169 133444170

XMA:	102222635 102222890 102223144

XCO:	114151212 114151221 114151228

XHE:	116729101 116729638 116732254

PRET:

103466509 103466510 103466511

PFOR:

103141299 103141300 103141301

PLAI:

106955830 106955832 106955833

PMEI:

106921859 106921860 106921863

GAF:	122835839 122835840(fads2) 122835841

PPRL:

129358437(fads2) 129358445 129361675

CVG:	107096151 107096160 107096161

CTUL:

119787411 119787428 119787429

GMU:	124878229 124878243(fads2) 124878251

NFU:	107388683 107388684 107388685 107388686

KMR:	108230083(fads2) 108230084

ALIM:

106521189 106521190 106521191

NWH:	119416317 119416318(fads2) 119416319 119416460

AOCE:

111582148(fads2)

MCEP:

125014531(fads2)

CSEM:

103380276(fads2)

POV:	109623584(fads2)

SSEN:

122760510 122775367(fads2)

HHIP:

117763209(fads2) 117777344

HSP:	118109441(fads2)

SMAU:

118314794 118314795(fads2)

LCF:

108886851

SDU:	111229900(fads2)

SLAL:

111666947(fads2)

XGL:	120793558(fads2)

HCQ:	109507604(fads2)

SSCV:

125970130

SBIA:

133502004(fads2)

PEE:	133402376(fads2)

PTAO:

133478499(fads2)

BPEC:

110167702(fads2)

MALB:

109971223 109971244

BSPL:

114856803(fads2)

SJO:	128359300(fads2)

SASA:

100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b)

STRU:

115192896 115192933 115192934 115192935

OTW:	112237565 112237566 112237567(fads2) 112264870

OMY:	100135943(fd6d) 110521168 110521170(fads2) 110522693

OGO:	124037455 124037456 124037457 124037484

ONE:	115124847 115124994 115128068 115144681

OKI:	109884127 109884128 109886014 109898183

OKE:	118359378 118376163 118376164 118382825

SALP:

112071110

SNH:	120042185 120042187 120042189 120052325

CCLU:

121540732 121540762 121540763 121540765

ELS:	105018065(fads2)

SFM:	108921004 108929076

PKI:	111833692 111846795

AANG:

118215202(fads2)

PSPA:

121330343

ARUT:

117434917(fads2)

PSEX:

120535951(fads2)

LCM:	102349949(FADS2)

CMK:

103174861

RTP:

109937250

CPLA:

122557873(fads2)

HOC:

132824407

LERI:

129705771(fads2)

PMRN:

116958616

LRJ:

133360007

BFO:

118428221

BBEL:

109463898

SPU:	105441844 581114 586594 756151

LPIC:

129256333 129261239 129281274

APLC:

110985398 110985778 110985855 110985906

AJC:

117113999

SKO:	100373185 100377526

DPA:

109544444

HRO:	HELRODRAFT_76893

LGI:	LOTGIDRAFT_113523 LOTGIDRAFT_143229 LOTGIDRAFT_198790

PVUL:

126807806 126831574 126832441 126832661 130014276

PCAN:

112556233 112566738

BGT:	106060307 106066585 106080202

GAE:	121387335 121387621 121387746

HRF:	124123564 124149223 124149233

HRJ:	124253964 124284977

CRG:	105318549 105330734

CVN:	111122923 111124908 111126646

CANU:

128156737 128193262

OED:	125679199 125681219

MYI:	110449385 110461670

PMAX:

117317607 117317694

MCAF:

127717696 127717925 127718229 127718232

MMER:

123538004 123538337 123563593

RPHI:

132725645 132731975 132755222

DPOL:

127845194 127846985 127849143 127865988

OBI:

106867675

OSN:

115223335

LAK:	106159034 106169957 112042655

SMM:	Smp_132740

SHX:	MS3_00001558(FADS1_1)

OVI:	T265_11098 T265_12033

AQU:

100632154

OLU:	OSTLU_3430

OTA:	OT_ostta13g01040

BPG:	Bathy17g00650

MIS:	MICPUN_82337

MPP:	MICPUCDRAFT_32578(JGI:MicpuC2_32578)

ACAN:

ACA1_260130

ECG:	E2348C_1358

ENA:	ECNA114_1401

ECOS:

EC958_1504

ECC:

c1695

ELN:	NRG857_06320

ESE:

ECSF_1212

EAB:	ECABU_c15100

ELC:

i14_1525

ELD:

i02_1525

ELF:

LF82_208

ECOJ:

P423_06960

EFE:

EFER_1726

EAL:	EAKF1_ch0205c

EMA:	C1192_05945

ESZ:	FEM44_21185

EEC:	EcWSU1_02601(des6)

ELG:	BH714_08855

ESA:	ESA_01449 ESA_01450

CSK:	ES15_1651 ES15_1652

CSZ:	CSSP291_07070 CSSP291_07075

CSJ:	CSK29544_02752 CSK29544_02753

CCON:

AFK62_11310 AFK62_11315

CDM:	AFK67_11655 AFK67_11660

CMW:	AFK63_06925 AFK63_06930

CTU:	CTU_24860 CTU_24870

LPNU:

KQ929_10745

SUPE:

P0H77_12165

YSI:	BF17_18735 BF17_18740

SMAR:

SM39_2335 SM39_2336

SMAC:

SMDB11_2131 SMDB11_2132

SMW:	SMWW4_v1c28750 SMWW4_v1c28760

SPE:	Spro_2862 Spro_2863

SRR:	SerAS9_2954 SerAS9_2955

SRL:	SOD_c26990(des1) SOD_c27000(des)

SRY:	M621_14700 M621_14705

SRS:	SerAS12_2955 SerAS12_2956

SRA:	SerAS13_2956 SerAS13_2957

SLQ:	M495_14805 M495_14810

SERF:

L085_14410 L085_14415

SERS:

SERRSCBI_13560 SERRSCBI_13565

SFW:	WN53_23625 WN53_23630

SFG:	AV650_19345 AV650_19350

SQU:	E4343_01725 E4343_01730

SSUR:

ATE40_010980 ATE40_010985

SURI:

J0X03_09570 J0X03_09575

SENP:

KHA73_14160 KHA73_14165

SNEM:

NLX84_14490 NLX84_14495

SNEV:

OI978_18120 OI978_18125

SFO:	Z042_22645 Z042_22650

RIU:	I2123_14800

ECA:

ECA0116

PATR:

EV46_00590 EV46_00595

PATO:

GZ59_01200 GZ59_01210

PCT:	PC1_4135 PC1_4136

PCC:	PCC21_001080 PCC21_001090

PCV:	BCS7_00370 BCS7_00375

PWA:	Pecwa_4416 Pecwa_4417

PPAR:

A8F97_19355 A8F97_19360

PEC:	W5S_4596 W5S_4597

PWS:	A7983_08465 A7983_08470

PPOA:

BJK05_17125 BJK05_17130

PBRA:

B5S52_21360 B5S52_21365

PPUJ:

E2566_20975 E2566_20980

PARI:

I2D83_21425 I2D83_21430

PVZ:	OA04_01280 OA04_01290

PPAV:

LOZ86_01345 LOZ86_01350

PPOO:

LW347_21025 LW347_21030

PACB:

M9782_02805

PCOA:

PJ912_13565

EPE:	CI789_00700 CI789_00705

ERWI:

GN242_04345 GN242_04350

ERP:	LJN55_18055 LJN55_18060

PRG:	RB151_029770(desA3) RB151_039160

PALA:

CO695_07030

PHEI:

NCTC12003_01329 NCTC12003_03452

PRQ:	CYG50_01490 CYG50_19130

PRJ:	NCTC6933_03440

PVC:	G3341_06785 G3341_17290

PMAG:

JI723_06695 JI723_17570

PHAG:

PZ638_06530 PZ638_17835

MWI:	MNY66_10115

LRI:	NCTC12151_00626

RGL:	CS053_14415

DTX:	ATSB10_36650

DKO:

I596_2530

PPSE:

BN5_0558

PAVL:

BKM03_28990

PSYI:

MME58_25550

PSKU:

KUIN1_50640

TOL:

TOL_2040

TOR:	R615_07535

OAI:	OLEAN_C27500

BSAN:

CHH28_12110

VCW:	GJQ55_07790

OME:	OLMES_1114

FPP:	FPB0191_02197 FPB0191_02198

SALV:

SALWKB2_0699

SCOM:

PYG29_08790

CVI:	CV_1644(desD) CV_2452

CVC:	BKX93_02755 BKX93_21455

CHRI:

DK842_15490

CHRB:

DK843_21020

RMN:	TK49_20560

RIN:	ACS15_5784

RWE:	KOL96_02900

BUB:

BW23_4705

BSTG:

WT74_24150

JAZ:	YQ44_03125

JAL:	BZG29_24440

JSV:	CNX70_24830

JAS:	FJQ89_14060

JLV:	G3257_25145

JAH:	JAB4_050380

JRI:	P9875_25520

ETB:	N7L95_24100

DMP:	FAK_12480 FAK_41190

ADE:

Adeh_1021

ACP:	A2cp1_3380

AFW:	Anae109_3187

ANK:	AnaeK_0374 AnaeK_1080

AORY:

AMOR_37230

MYX:	QEG98_06420

CCX:	COCOR_07436(des6)

SUR:	STAUR_0738

AGE:	AA314_05794

MBD:	MEBOL_001021 MEBOL_004617

HOH:

Hoch_5632

BSED:

DN745_02880 DN745_05975

PCAY:

FRD00_03300 FRD00_23105

SYN:	sll0262(desD(des6))

SYZ:	MYO_119490(desD(des6))

SYY:	SYNGTS_1931(desD)

SYT:	SYNGTI_1930(desD)

SYS:	SYNPCCN_1929(desD)

SYQ:	SYNPCCP_1929(desD)

SYJ:	D082_30330(desD)

SYO:	C7I86_10070

SYNP:

Syn7502_02943

CGC:	Cyagr_2722

AMR:

AM1_1073

KOV:	K9N68_09575

PSER:

ABRG53_2437

PGX:	OA858_22390

GEE:	GM3708_945

MAR:	MAE_48160(desD)

MPK:

VL20_3454

MIQ:	B5D77_04380

MVZ:	myaer102_21530(desD)

ARP:	NIES39_J03090(desD)

LFS:	HFV01_08435

OAC:	Oscil6304_3294

MIC:	Mic7113_1421

AWA:	AA650_11345 AA650_11350

HBQ:	QI031_00935

CALT:

Cal6303_1445

CALN:

NIES2098_27880(desD)

CALS:

NIES3974_16680(desD)

RIV:	Riv7116_4400

NSPH:

BDGGKGIB_02538(desA3)

TOQ:	HCG51_19350

ALAX:

NIES50_15150(desD)

PUV:	PUV_10250(des6)

WCH:

wcw_0161

AMOB:

HG15A2_45670(desA3)

FMR:	Fuma_00671(desA)

GES:	VT84_04450 VT84_12735

GOG:	C1280_12875

GMS:	SOIL9_48780 SOIL9_57870

FTJ:

FTUN_3002

TSPH:

KIH39_09120

SACI:

Sinac_0398

HBS:	IPV69_24075

TPX:	Turpa_1866

ADIN:

H7849_03985

MCOS:

GM418_05800 GM418_21175 GM418_23330

CPI:	Cpin_5676 Cpin_5677

CBAE:

COR50_08285

CHIT:

FW415_01170 FW415_18530

CHIH:

GWR21_29075

CFIL:

MYF79_18645

CHF:	KTO58_22430

CHOR:

MKQ68_03065 MKQ68_16115

CSAC:

SIO70_03010 SIO70_19005 SIO70_30580

NKO:	Niako_0028 Niako_2214 Niako_5619 Niako_6564

NSO:	NIASO_08625

NIA:	A8C56_04725

NYN:	U0035_04485 U0035_07075

FLA:	SY85_04130 SY85_23690 SY85_23835

FGG:	FSB75_19400

ARB:	A9P82_07590 A9P82_12885

ARK:	D6B99_14620

AGI:	FSB73_05040 FSB73_09885 FSB73_11865

ATEE:

K9M52_05815 K9M52_10175

ARAC:

E0W69_012610

FLN:	FLA_2034 FLA_3880

PSEG:

D3H65_02955 D3H65_14270 D3H65_21685

PGIN:

FRZ67_13380 FRZ67_21700

PGO:	FSB84_05680 FSB84_28195

FLS:	GLV81_10500

LACS:

H4075_12235 H4075_17930

FEI:	K9M53_08205

FLP:	LK994_06745 LK994_09070 LK994_14080

FLC:	KJS93_09095 KJS93_09225 KJS93_12245 KJS93_12775 KJS93_13655

FLV:	KJS94_07185 KJS94_10255 KJS94_17800

SEDT:

TEGAF0_01790

THEO:

IMW88_05580 IMW88_06715

HHY:	Halhy_3263 Halhy_3651

SGN:	SGRA_0953 SGRA_3738

PHE:

Phep_0579

PEP:	AQ505_23795

PCM:	AY601_0291

PSTY:

BFS30_12445

PEK:	FFJ24_000610 FFJ24_000615 FFJ24_009255

PROE:

H9L23_04740 H9L23_11790

PEX:	IZT61_16130

PMUO:

LOK61_08145

PRK:	H9N25_10080

PGJ:	QG516_17325

PSN:	Pedsa_0092

SHG:	Sph21_1254

SHT:	KO02_08730

SPHN:

BV902_16925

SMIZ:

4412673_01383(desA3_1) 4412673_04012(desA3_2)

SPSC:

E2P86_12690 E2P86_12970

SPHE:

GFH32_00630 GFH32_03190 GFH32_06585 GFH32_11525

SPDR:

G6053_13355

SDJ:	NCTC13534_02135(desA3)

SSPI:

I6J01_08990

SSIY:

JVX97_14820

SFAE:

MUK51_09655

SBAM:

SCB77_22100

SCN:	Solca_2015

SLAS:

L2B55_10575

MGIN:

FRZ54_12455

MDJ:	LLH06_12505

AGD:	FRZ59_03065 FRZ59_14730

OLI:	FKG96_03215

SBX:	CA265_00630 CA265_00635 CA265_10185

CMR:	Cycma_1461

CAMU:

CA2015_1137 CA2015_1138 CA2015_1357 CA2015_4277

BBD:	Belba_0611 Belba_0817

EVI:	Echvi_1008 Echvi_2487

EST:	DN752_11560 DN752_18445

ECHI:

FKX85_04965 FKX85_20520

EMAI:

KZP23_05365

ALM:	AO498_08640

ALGO:

GYM62_06400 GYM62_12700

MDA:	IPZ59_05475 IPZ59_05660 IPZ59_16190

CHU:	CHU_3762 CHU_3764

SLI:

Slin_4655

SRD:	SD10_21800

SMON:

AWR27_12490

SPIR:

CWM47_23570

SPIK:

EXU85_12795

SPIB:

G8759_25875

STAE:

HNV11_11570 HNV11_21120

SOQ:	LQ777_30240

SFOL:

H3H32_15745 H3H32_16765

SENF:

GJR95_40500

RHOZ:

GXP67_00645 GXP67_00790 GXP67_19925 GXP67_34085 GXP67_34095

DFE:	Dfer_0898 Dfer_3204

DSN:	HWI92_21275

DYC:	NFI80_21445

DFQ:	NFI81_00830 NFI81_22590

DCN:	MUK70_26880

DPF:	ON006_21660

RSI:	Runsl_2603 Runsl_4114

RUN:	DR864_01875 DR864_13000

RUP:	DTQ70_15945

EMZ:	MB380_12550

FAE:	FAES_3358 FAES_4414(desD)

FIB:	A6C57_20910

ALS:	DJ013_11725

MAQA:

LAG90_05115 LAG90_08950 LAG90_18070

FLI:	Fleli_2211 Fleli_3763

HSW:	Hsw_0774 Hsw_3072

HYM:	N008_13645

HYD:	PK28_13650

HYE:	AM218_02795

HYG:	AUC43_10760 AUC43_17580

HYP:	A0257_10485

HYZ:	AXW84_22490

HNV:	DDQ68_16005

HYH:	D3Y59_00565

HYJ:	FHG12_14055 FHG12_18880

HRS:	HER32_05380 HER32_10030

HBN:	GUY19_19465 GUY19_19470

HTS:	HMJ29_01695 HMJ29_10905

HMT:	MTP16_22770

HTB:	MTX78_16955

HYK:	O9Z63_11765

HSK:	H4317_05740 H4317_05745 H4317_07045

HCW:	O3303_09875

HSB:	MWH26_12760 MWH26_17065

HAEI:

MUN82_13020

HVL:	MUN86_16805

HCF:	MUN80_23735 MUN80_23740

PKO:	PKOR_12515 PKOR_12520 PKOR_15525

PACT:

CA264_02175 CA264_03165 CA264_03620

RUF:	TH63_04060 TH63_14235

RTI:	DC20_14245 DC20_14660

RUD:	TH61_12240

NIB:	GU926_18085

ADD:	HUW48_10675

ASWU:

HUW51_01025 HUW51_20485

MTT:	Ftrac_1277 Ftrac_1374

MHAA:

Q3Y49_01250 Q3Y49_18410

FPF:	DCC35_20270

CLIT:

OQ292_20050

IRO:	RT717_15385 RT717_20555 RT717_21990

FBT:	D770_01380 D770_10140 D770_22385

CHRW:

KA713_17535

CHK:	D4L85_06785 D4L85_13615 D4L85_30080

FUV:	JR347_07595 JR347_12655 JR347_15925

FMM:	LVD15_04060 LVD15_13350 LVD15_26280 LVD15_26705

FUA:	LVD17_02965 LVD17_14155 LVD17_17735 LVD17_26230

FLW:	LVD16_07845 LVD16_11895 LVD16_25410

REK:	N6H18_09105

RCG:	N7E81_09120 N7E81_17880 N7E81_18455

PRHO:

PZB74_19095

TPEL:

P0M28_09140 P0M28_30060

RSR:	T7867_08970

ATK:	AUTU_29800 AUTU_45020

GFO:

GFO_1576

GRL:	LPB144_03720

GRS:	C7S20_13800 C7S20_17135 C7S20_18515

FPS:

FP0413

FPC:	FPSM_00450

FPY:	FPG101_02255

FPO:	FPG3_02170

FPQ:	IB65_01940

FPV:	IA03_02025

FPW:	IA04_01965

FPK:	IA06_02005

FPSZ:

AMR72_11020 AMR72_12580

FJO:	Fjoh_1748 Fjoh_4604

FJG:	BB050_00859(desA3_1) BB050_02987(desA3_2)

FBR:	FBFL15_0640

FCO:	FCOL_03090

FIN:

KQS_11875

FGL:	EM308_06050 EM308_06795

FCM:	BIW12_09460

FFA:	FFWV33_01325

FAT:	DVK85_08110

FKI:	FK004_01385

FPAL:

HYN49_01635

FMG:	HYN48_01600

FALB:

HYN59_06915

FCR:	HYN56_07485 HYN56_09200 HYN56_22190

FSE:	DI487_00875 DI487_09345

FSN:	GS03_00241

FNK:	E1750_13170

FAK:	FUA48_01500

FFL:	HYN86_08210 HYN86_18615

FEN:	J0383_06845 J0383_08685 J0383_18340

FCV:	AWN65_01780

FOE:	JJC03_07225

FSD:	LXD69_02525

FLO:	K1I41_01625

FCC:	LOS86_02380

FCB:	LOS89_10880

FPB:	NLJ00_09245 NLJ00_22200

FEH:	LZF87_01210

FAZ:	M0M57_04100

FBI:	L0669_09080 L0669_20585

FCS:	TRV642_1801

FAO:	SHINM13_01670

FAN:	GENT5_01820

FPLU:

NLG42_08485 NLG42_21180

FHU:	M0M44_09045 M0M44_21335

FCU:	NOX80_01095

FPEC:

Q1W71_02660 Q1W71_21030

FOK:	KK2020170_03000

RBI:	RB2501_02670

ZPR:	ZPR_0940 ZPR_1492

CAT:	CA2559_07355

FBC:	FB2170_16751

MARM:

YQ22_03825

MART:

BTR34_03930

MARB:

CJ263_13770

MARE:

EJ994_00970

MLIO:

NYZ99_14280

CAO:	Celal_2252

CLY:	Celly_0637

CLH:	IX49_02930

CBAL:

M667_08640

CBAT:

M666_08605

COMN:

PBN93_03195

KDI:	Krodi_1870

DOK:	MED134_12621

DDO:	I597_1302(desA3)

DOD:	DCS32_02495

LAN:	Lacal_0517

LVN:	BWR22_13235

LACI:

CW733_04270 CW733_09735

ZGA:	ZOBELLIA_1067(des6-2) ZOBELLIA_755(des6-1)

ZLA:	Q5W13_03625

ASL:	Aeqsu_0518

AEV:	EI546_14540

AIC:	JK629_01570 JK629_12490

PTQ:	P700755_002699

PSYD:

IMZ30_02630

POM:	MED152_06405

POB:	LPB03_14685

PRN:	BW723_00980

POLA:

BXQ17_06895

POA:	CW731_14315

PHAL:

H9I45_13935

PLIT:

K8354_11165

PPEC:

H9W90_09185

PBAT:

JL193_04995

PCEA:

J3359_15260

PUN:	NQP51_15885

PHG:	KCTC32516_00465(desA3)

WIN:

WPG_2001

WIJ:	BWZ20_06125

SZE:	AW14_08200

AHZ:	APS56_08280

SYI:	SB49_00400

TDI:	AUW17_12185

TEN:	LPB136_09710

TJE:	TJEJU_3739

TMAR:

MARIT_2781

TMP:	F9Y86_06280

TOV:	PG911_17440

TRT:	PG912_01315

TPAC:

PG913_11730

TFI:	PJJ26_12910

TTG:	P8625_12730

TSIG:

D6T69_04030

LUT:	Lupro_06980

LUL:	LPB138_09110

WFU:	AXE80_00775

FOR:	FORMB_06270

FOH:	FORMA_06960

FOP:	FNB79_06940

SALT:

AO058_00115

SMIS:

LDL76_09110

SEON:

BWZ22_11950 BWZ22_15155

AALG:

AREALGSMS7_02543(desA3)

OLL:	CW732_06150

OAQ:	DZC78_12695

FEK:	C1H87_06880

TAJ:	C1A40_11340

AUE:	C5O00_08760

MARF:

CJ739_552

AQB:	D1818_09380 D1818_09485 D1818_09490

AQA:	D1815_21665 D1815_21670 D1815_21765

AQD:	D1816_10945

AQE:	NBT05_08765

EMAR:

D1013_05915 D1013_15030

MUR:	EQY75_02165

PSYN:

E9099_04030

PPON:

MUN68_013590

AFLA:

FHG64_13475

ANP:	FK178_00105

OCI:	FEZ18_11675

MGEL:

G5B37_12950

MESQ:

C7H62_0634

GAA:	HX109_09955

CAGG:

HYG79_02970

MARX:

INR76_01415

LPAL:

LDL79_12280

SINH:

LS482_08330 LS482_12605

ASAG:

FGM00_02900

FLG:	LV716_02865

FLB:	LV704_03710

MRS:	Murru_0575 Murru_2048

MLT:

VC82_2131

MUT:	GVT53_01095

MAQI:

LDL77_10735 LDL77_12845

SPON:

HME9304_02346

SABU:

MBM09_05465

ZSP:	MQE36_09485

BIA:	GMA17_04560 GMA17_09985

FBE:	FF125_11040 FF125_18070

FBM:	MQE35_03580

SAHN:

JRG66_03265

ALUT:

O5O44_13390

LUY:	QZH61_13390

AEST:

RBH94_09470

MANG:

RBH95_14805

HWS:	RNZ46_09970

FBQ:	D1817_13600

EAO:

BD94_3599

EMN:	M876_15070

EEN:	BBD30_08675

ELB:	VO54_03046

EMG:	BBD33_05475

EGM:	AYC65_19675

ELZ:	FCS00_12860

ELIZ:

JCR23_12755

CHZ:

CHSO_0007

CGN:	OK18_10425

CIH:	ATE47_14660

CIO:	CEQ15_20755

CPIP:

CJF12_09160 CJF12_11850

CARH:

EGY05_00090 EGY05_16690

CSHA:

EG350_17865

CNK:	EG343_16780

CJT:	EG359_17215

CIL:	EG358_03810

CBEN:

EG339_08225

CGLE:

NCTC11432_03868

CTAI:

NCTC12078_01616

CLAC:

EG342_08295

CTAK:

4412677_01961

CNP:	M0D58_13535

CCAO:

H5J24_19795

CRHI:

KB553_18450

CCAB:

PFY12_11545

CHRJ:

CHRYMOREF3P_3431

CORA:

N0B40_13105

CFLU:

ODZ84_16640

CIV:	IMZ16_00065

FTE:	Fluta_0285 Fluta_0832 Fluta_1718 Fluta_4072

FLU:	CHH17_00735 CHH17_06930 CHH17_10485 CHH17_16625

CRM:	K6119_02165 K6119_02195 K6119_18185

OHO:	Oweho_1245 Oweho_2759

CHYD:

H4K34_06255

PTAN:

CRYO30217_01395

BBAU:

AEM51_07385 AEM51_12040

SRG:	XF24_00844(desA3)

» show all

Reference

1 [PMID:7212717]

Authors

Okayasu T, Nagao M, Ishibashi T, Imai Y.

Title

Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes.

Journal

Arch Biochem Biophys 206:21-8 (1981)
DOI:10.1016/0003-9861(81)90061-8

Reference

2 [PMID:9867867]

Authors

Cho HP, Nakamura MT, Clarke SD

Title

Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.

Journal

J Biol Chem 274:471-7 (1999)
DOI:10.1074/jbc.274.1.471

Sequence

[hsa:9415] [mmu:56473]

Reference

3 [PMID:10903473]

Authors

Sprecher H

Title

Metabolism of highly unsaturated n-3 and n-6 fatty acids.

Journal

Biochim Biophys Acta 1486:219-31 (2000)
DOI:10.1016/S1388-1981(00)00077-9

Reference

4 [PMID:12713571]

Authors

Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM

Title

Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.

Journal

J Invest Dermatol 120:707-14 (2003)
DOI:10.1046/j.1523-1747.2003.12123.x

Reference

5 [PMID:15769252]

Authors

Domergue F, Abbadi A, Zahringer U, Moreau H, Heinz E

Title

In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri.

Journal

Biochem J 389:483-90 (2005)
DOI:10.1042/BJ20050111

Sequence

[ota:OT_ostta13g01040]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.19.3

IUBMB Enzyme Nomenclature:

1.14.19.3

ExPASy - ENZYME nomenclature database:

1.14.19.3

BRENDA, the Enzyme Database:

1.14.19.3

CAS:

9082-66-0

DBGET integrated database retrieval system