KEGG ENZYME: 1.14.19.53

ENZYME: 1.14.19.53

Entry

EC 1.14.19.53               Enzyme

Name

all-trans-retinol 3,4-desaturase;
CYP27C1 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Sysname

all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase

Reaction(IUBMB)

all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2 = all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O [RN:R11952]

Reaction(KEGG)

R11952

Substrate

all-trans-retinol [CPD:C00473];
reduced adrenodoxin [CPD:C00662];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

all-trans-3,4-didehydroretinol [CPD:C21797];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme thiolate) enzyme found in vertebrates. The enzyme is also active with retinal and retinoic acid.

History

EC 1.14.19.53 created 2018

Pathway

ec00830

Retinol metabolism

Orthology

K17951

all-trans-retinol 3,4-desaturase

Genes

HSA:	339761(CYP27C1)

PTR:

470525

PPS:	100975504(CYP27C1)

GGO:

101148971

PON:

100453764

NLE:

100600882

HMH:

116462960

MCC:

713954

MCF:	102138872(CYP27C1)

MTHB:

126933065

MNI:

105492430

CSAB:

103216882(CYP27C1)

CATY:

105592085

PANU:

101003912

TGE:

112636508

MLEU:

105539995

RRO:

104662434

RBB:

108533024

TFN:

117095437

PTEH:

111551563

CANG:

105511519

CJC:

100407433

SBQ:

101050984

CIMI:

108297966(CYP27C1)

CSYR:

103276600

MMUR:

105857517

LCAT:

123643351

PCOQ:

105814827

OGA:

100960218

NCAR:

124980573

MMMA:

107136674

OCU:

100355448

OPI:

101519867

TUP:

102486613

GVR:

103591823

CFA:	483869(CYP27C1)

CLUD:

112652432

VVP:

112932715

VLG:

121482057

NPO:

129503811

AML:

100475175

UMR:

103658573

UAH:

113263376

UAR:

123779504

ELK:

111160854

LLV:

125096318

MPUF:

101672135

MNP:

132013080

MLK:

131826897

NVS:

122902755

ORO:

101369154

EJU:

114207320

ZCA:

113919425

MLX:

118012566

NSU:

110585737

LWW:

102738439

FCA:	101096908(CYP27C1)

PYU:

121030403

PCOO:

112848712

PBG:

122481228

PVIV:

125173292

LRUF:

124515749

PTG:

102957625

PPAD:

109278795

PUC:

125911701

AJU:

106966380

HHV:

120245941

BTA:	617338(CYP27C1)

BOM:

102274061

BIU:

109565330

BBUB:

102407599

BBIS:

105005081

CHX:

102179328

OAS:

101118856

BTAX:

128043653

ODA:

120854056

CCAD:

122453906

MBEZ:

129538154

SSC:

100517560

CFR:

102504552

CBAI:

105068581

CDK:

105084485

VPC:

102531160

BACU:

103017184

BMUS:

118898171

LVE:

103083694

OOR:

101269815

DLE:

111183411

PCAD:

102981411

PSIU:

116757039

NASI:

112395012

ECB:	100051659(CYP27C1)

EPZ:

103562192

EAI:

106834094

SARA:

101545408

TMU:

101354619

DNM:

101412325

MDO:

100026810

GAS:

123239379

SHR:

100916977

AFZ:

127554296

PCW:

110194704

OAA:

100089911

GGA:	424227(CYP27C1)

PCOC:

116227347

MGP:

100542744

CJO:

107316860

TPAI:

128076664

LMUT:

125697181

NMEL:

110399800

APLA:

101801511

ACYG:

106045912

CATA:

118259868

AFUL:

116490455

TGU:

100225584

LSR:

110468322

SCAN:

103814334

PMOA:

120497349

OTC:

121337872

PRUF:

121356668

GFR:

102033475

FAB:

101811458

OMA:

130255660

PHI:

102112535

PMAJ:

107207282

CCAE:

111932211

CCW:

104693991

CBRC:

103625419

ETL:

114055572

ZAB:

102061648

ACHL:

103803665

SVG:

106861390

MMEA:

130572820

HRT:

120755199

FPG:

101921287

CLV:

102092786

EGZ:

104133721

NNI:

104020396

PCRI:

104033283

PLET:

104613748

EHS:

104503200

PCAO:

104049209

ACUN:

113482262

TALA:

104355522

PADL:

103916539

AFOR:

103895456

ACHC:

115343271

HALD:

104319536

HLE:

104833254

AGEN:

126038701

GCL:

127018631

CCRI:

104169131

CSTI:

104560750

CMAC:

104477361

MUI:

104539105

BREG:

104629291

FGA:

104069301

GSTE:

104250432

LDI:

104339886

MNB:

103769754

OHA:

104335235

NNT:

104403096

SHAB:

115608327

DPUB:

104309823

PGUU:

104462388

ACAR:

104517608

CPEA:

104387464

AVIT:

104274981

CVF:

104288476

RTD:

128913044

CUCA:

104056203

TEO:

104377354

BRHI:

104499308

AAM:

106499209

AROW:

112972059

NPD:

112946090

TGT:

104568404

DNE:

112980579

SCAM:

104139600

ASN:

102378794

AMJ:	102574953(CYP27C1)

CPOO:

109322640

GGN:

109301453

PSS:

102448341

CMY:

102940478

CCAY:

125645045

DCC:

119863446

CPIC:

101935484

TST:

117885095

CABI:

116839281

MRV:

120375086

ACS:

100557779

ASAO:

132774187

PVT:

110085301

SUND:

121919156

PBI:

103048791

PMUR:

107302019

CTIG:

120298276

TSR:

106546919

PGUT:

117668268

APRI:

131189329

PTEX:

113441191

NSS:

113410661

VKO:

123027473

PMUA:

114603555 114603564

PRAF:

128420851

ZVI:

118091379

HCG:

128340236

GJA:

107113561

STOW:

125427141

EMC:

129325047

XLA:	108701260 447625(cyp27c1.L) 735141(cyp27c1.S)

XTR:	496805(cyp27c1)

NPR:

108785388

RTEM:

120944247

BBUF:

121008632

BGAR:

122923874

DRE:	558396(cyp27c1)

SRX:	107705550 107706664

SANH:

107660023 107677575

SGH:	107581347 107584837

CCAR:

109045192 109080434

CAUA:

113050868 113092310

CGIB:

127959176 128016160

PTET:

122346589

LROH:

127166630

OMC:

131542389

PPRM:

120491640

RKG:

130101288

MAMB:

125274239

CIDE:

127514747

MASI:

127446271 127448771

TROS:

130557013

TDW:

130424729

MANU:

129450945

IPU:

108272716

IFU:

128615905

PHYP:

113538219

SMEO:

124393172

TFD:

113651072

TVC:

132844941

AMEX:

103026207

CMAO:

118807845

EEE:

113584084

CHAR:

105892705

TRU:

101074060

TFS:

130517963

LCO:

104918263

NCC:	104966145 104966146

TBEN:

117471487

CGOB:

115027128

PGEO:

117461788

GACU:

117548060

EMAC:

134862601

ELY:

117260539

EFO:

125882369

PLEP:

121947707

SLUC:

116054722 116054723

ECRA:

117948167

ESP:	116670746 116671237

PFLV:

114556809 114558100

GAT:

120834626

PPUG:

119227784

AFB:

129104720

CLUM:

117749994

PSWI:

130192606

MSAM:

119890195

SCHU:

122879184 122880162

CUD:

121514646

ALAT:

119018381

MZE:

101466396

ONL:

100700192

OAU:

116311706

OLA:

101157281

OML:

112160631

CSAI:

133460588

XMA:

102223373

XCO:

114142722

XHE:

116718483

PRET:

103461994

PFOR:

103143523

PLAI:

106944717

PMEI:

106914830

GAF:

122846514

PPRL:

129369693

CVG:

107082507

CTUL:

119771877

GMU:

124866500

NFU:

107381651

KMR:

108250623

ALIM:

106513953

NWH:

119428924

AOCE:

111564848

MCEP:

125005862

CSEM:

103398814

POV:

109624782

SSEN:

122772870

HHIP:

117759225

HSP:

118113895

SMAU:

118302790

LCF:

108887985

SDU:

111238623

SLAL:

111652557

XGL:

120793403

HCQ:

109524630

SSCV:

125966700

SBIA:

133498376

PEE:

133416013

PTAO:

133472169

BPEC:

110173034

MALB:

109964498

BSPL:

114852263

SJO:

128381834

SASA:

106575940 106595593

STRU:

115183068 115184096

OTW:	112242330 121838678

OMY:	110510834 110519502

OGO:	124021071 124027374

OKI:

116361459

OKE:

118382529

SNH:	120035602 120040682

CCLU:

121563781

ELS:

105020091

SFM:	108920654 108942618

PKI:

111852224

AANG:

118213728

LOC:

102695873

PSPA:

121323562

ARUT:

117404920

PSEX:

120531264

LCM:

102367688

CMK:

103189034

RTP:

109912647

CPLA:

122551942

HOC:

132817319

LERI:

129693907

PMRN:

116948607

LRJ:

133349759

PCHN:

125029948 125034086

HRF:

124116286

HRJ:

124292172

CVN:

111136095

PMAX:

117337533

» show all

Reference

1 [PMID:26549260]

Authors

Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC

Title

Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.

Journal

Curr Biol 25:3048-57 (2015)
DOI:10.1016/j.cub.2015.10.018

Sequence

[dre:558396]

Reference

2 [PMID:27059013]

Authors

Kramlinger VM, Nagy LD, Fujiwara R, Johnson KM, Phan TT, Xiao Y, Enright JM, Toomey MB, Corbo JC, Guengerich FP

Title

Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.