KEGG   ENZYME: 1.14.19.62
Entry
EC 1.14.19.62               Enzyme                                 
Name
secologanin synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
loganin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (ring-cleaving)
Reaction(IUBMB)
loganin + [reduced NADPH---hemoprotein reductase] + O2 = secologanin + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R03555]
Reaction(KEGG)
R03555;
(other) R05833
Substrate
loganin [CPD:C01433];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
secologanin [CPD:C01852];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids.
History
EC 1.14.19.62 created 2002 as EC 1.3.3.9, transferred 2018 to EC 1.14.19.62
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13400  secologanin synthase
Reference
1
  Authors
Yamamoto, H., Katano, N., Ooi, Y. and Inoue, K.
  Title
Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures.
  Journal
Phytochemistry 50:417-422 (1999)
Reference
2  [PMID:10656401]
  Authors
Yamamoto H, Katano N, Ooi A, Inoue K.
  Title
Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450.
  Journal
Phytochemistry 53:7-12 (2000)
DOI:10.1016/S0031-9422(99)00471-9
Reference
3  [PMID:11135113]
  Authors
Irmler S, Schroder G, St-Pierre B, Crouch NP, Hotze M, Schmidt J, Strack D, Matern U, Schroder J
  Title
Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase.
  Journal
Plant J 24:797-804 (2000)
DOI:10.1111/j.1365-313X.2000.00922.x
  Sequence
[ag:AAA33106]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.62
IUBMB Enzyme Nomenclature: 1.14.19.62
ExPASy - ENZYME nomenclature database: 1.14.19.62
BRENDA, the Enzyme Database: 1.14.19.62
CAS: 258339-71-8

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (58)   
   UniProt (56)   
   SWISS-PROT (2)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (5)   
   InterPro (5)   
All databases (83)   

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