Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy

(S)-N-methylcoclaurine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (C-O phenol-coupling)

(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH---hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R04694]

R04694;
(other) R05210 R05215
Reaction

(S)-N-methylcoclaurine [CPD:C05176];
(R)-N-methylcoclaurine [CPD:C05243];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine.

EC 1.14.19.66 created 1999 as EC 1.1.3.34, transferred 2002 to EC 1.14.21.3, transferred 2018 to EC 1.14.19.66

1  [PMID:8380416]