KEGG ENZYME: 1.14.19.70

ENZYME: 1.14.19.70

Entry

EC 1.14.19.70               Enzyme

Name

mycocyclosin synthase;
CYP121;
rv2276 (locus name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Sysname

cyclo(L-tyrosyl-L-tyrosyl),reduced ferredoxin:oxygen oxidoreductase (diarylbridge-forming)

Reaction(IUBMB)

cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O [RN:R10323]

Reaction(KEGG)

R10323

Substrate

cyclo(L-tyrosyl-L-tyrosyl) [CPD:C20516];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

mycocyclosin [CPD:C20517];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product.

History

EC 1.14.19.70 created 2013 as EC 1.14.21.9, transferred 2018 to EC 1.14.19.70

Orthology

K17483

mycocyclosin synthase

Genes

MTU:	Rv2276(cyp121)

MTV:

RVBD_2276

MTC:

MT2336

MRA:	MRA_2295(cyp121)

MTF:	TBFG_12301

MTB:	TBMG_01706

MTK:	TBSG_01716

MTZ:	TBXG_001689

MTG:	MRGA327_14025

MTE:	CCDC5079_2109

MTUR:

CFBS_2409(cyp121)

MTL:	CCDC5180_2081

MTO:	MTCTRI2_2311(cyp121)

MTD:	UDA_2276(cyp121)

MTJ:	J112_12205

MTUC:

J113_15840

MTUE:

J114_12200

MTX:	M943_11770

MTUT:

HKBT1_2400(cyp121)

MTUU:

HKBT2_2402(cyp121)

MTQ:	HKBS1_2406(cyp121)

MBO:	BQ2027_MB2299(cyp121)

MBB:	BCG_2293(cyp121)

MBT:	JTY_2287(cyp121)

MBM:	BCGMEX_2281(cyp121)

MBK:	K60_023610

MBX:

BCGT_2100

MMIC:

RN08_2523

MCE:	MCAN_23001(cyp121)

MCQ:	BN44_50222(cyp)

MCV:	BN43_31518(cyp)

MCX:	BN42_40197(cyp)

MCZ:	BN45_50612(cyp)

MORY:

MO_002386(cyp121)

MLJ:	MLAC_22970(cyp121)

MOT:	LTS72_08580

NTP:	CRH09_14610

NOZ:	DMB37_28475

NAH:	F5544_25075

NIE:	KV110_23805

SVE:

SVEN_1865

SVT:	SVTN_10710

SLD:

T261_7888

SRW:	TUE45_00817

SGS:	AVL59_26765

SPUN:

BFF78_39740

SGV:	B1H19_37510

SLAU:

SLA_4278

SALJ:

SMD11_0297

SLX:	SLAV_12480

SLK:	SLUN_02670

SCYA:

EJ357_25510

SGZ:	C0216_06095

SVN:	CP980_02820

SRK:	FGW37_32710

SFIC:

EIZ62_17685

SRIM:

CP984_00425 CP984_04050

SCHA:

CP983_19790

SGX:	H4W23_11130

SNF:	JYK04_05847 JYK04_07983

SBRO:

GQF42_05395

SHUN:

DWB77_02435

SFEU:

IM697_43415

SMOB:

J7W19_32325

SHK:	J2N69_29165

SGOB:

test1122_04685

SDUR:

M4V62_06460

SYAN:

NRK68_32840

STAA:

LDH80_28225

SXT:	KPP03845_105190

SLON:

LGI35_44005

SOV:	QZH56_35135

SHAU:

K9S39_12105

SROC:

RGF97_24955

STTN:

BSL84_32800

SINN:

ABB07_35525

KIT:	CFP65_6206

STRH:

GXP74_30935

KPHY:

AOZ06_26070

» show all

Reference

1 [PMID:19416919]

Authors

Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courcon M, Masson C, Dugave C, Genet R, Pernodet JL, Gondry M

Title

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.

Journal

Proc Natl Acad Sci U S A 106:7426-31 (2009)
DOI:10.1073/pnas.0812191106

Sequence

[mtu:Rv2276]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.19.70

IUBMB Enzyme Nomenclature:

1.14.19.70

ExPASy - ENZYME nomenclature database:

1.14.19.70

BRENDA, the Enzyme Database:

1.14.19.70

DBGET integrated database retrieval system