KEGG ENZYME: 1.14.19.71

ENZYME: 1.14.19.71

Entry

EC 1.14.19.71               Enzyme

Name

fumitremorgin C synthase;
ftmE (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Sysname

tryprostatin A,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase

Reaction(IUBMB)

tryprostatin A + [reduced NADPH---hemoprotein reductase] + O2 = fumitremorgin C + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R10416]

Reaction(KEGG)

R10416

Substrate

tryprostatin A [CPD:C20607];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

fumitremorgin C [CPD:C20604];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein. The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.

History

EC 1.14.19.71 created 2013 as EC 1.14.21.10, transferred 2018 to EC 1.14.19.71

Pathway

ec00404

Staurosporine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K17827

fumitremorgin C synthase