Entry Name (+)-piperitol/(+)-sesamin synthase;
Class Oxidoreductases;BRITE hierarchy
Sysname (+)-pinoresinol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB) (1) (+)-pinoresinol + [reduced NADPH-hemoprotein reductase] + O2 = (+)-piperitol + [oxidized NADPH-hemoprotein reductase] + 2 H2O [RN:
R12153 ];
(2) (+)-piperitol + [reduced NADPH-hemoprotein reductase] + O2 = (+)-sesamin + [oxidized NADPH-hemoprotein reductase] + 2 H2O [RN:
R12154 ]
Reaction(KEGG) Substrate (+)-pinoresinol [CPD:
C05366 ];
[reduced NADPH-hemoprotein reductase];
O2 [CPD:
C00007 ];
(+)-piperitol [CPD:
C21954 ]
Product (+)-piperitol [CPD:
C21954 ];
[oxidized NADPH-hemoprotein reductase];
H2O [CPD:
C00001 ];
(+)-sesamin [CPD:
C10882 ]
Comment A cytochrome P-450 (heme-thiolate) protein. Isolated from Sesamum indicum (sesame) and S. radiatum (black sesame).
History EC 1.14.19.74 created 2018
Orthology K22995 (+)-piperitol/(+)-sesamin synthase
Genes SIND : 105176326 105177765
Taxonomy Reference Authors Ono E, Nakai M, Fukui Y, Tomimori N, Fukuchi-Mizutani M, Saito M, Satake H, Tanaka T, Katsuta M, Umezawa T, Tanaka Y
Title Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin.
Journal Sequence Other DBs
