KEGG   ENZYME: 1.14.99.4
Entry
EC 1.14.99.4                Enzyme                                 
Name
progesterone monooxygenase;
progesterone hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
Reaction(IUBMB)
progesterone + reduced acceptor + O2 = testosterone acetate + acceptor + H2O [RN:R02212]
Reaction(KEGG)
R02212
Substrate
progesterone [CPD:C00410];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
testosterone acetate [CPD:C03027];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
Has a wide specificity. A single enzyme from ascomycete the Neonectria radicicola (EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.12 androst-4-ene-3,17-dione monooxygenase.
History
EC 1.14.99.4 created 1972, modified 1999
Reference
1  [PMID:5950688]
  Authors
Rahm MA, Sih CJ.
  Title
Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain.
  Journal
J Biol Chem 241:3615-23 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.4
IUBMB Enzyme Nomenclature: 1.14.99.4
ExPASy - ENZYME nomenclature database: 1.14.99.4
BRENDA, the Enzyme Database: 1.14.99.4
CAS: 37256-85-2

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Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
All databases (12)   

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