Entry
Name
gamma-glutamyl hercynylcysteine S-oxide synthase;
EgtB
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
hercynine,gamma-L-glutamyl-L-cysteine:oxygen oxidoreductase [gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB)
hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O [RN:
R11013 ]
Reaction(KEGG)
Substrate
Product
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:
C20995 ];
H2O [CPD:
C00001 ]
Comment
Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and gamma-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine.
History
EC 1.14.99.50 created 2015
Pathway
Orthology
K18912 gamma-glutamyl hercynylcysteine S-oxide synthase
Genes
MBAI : MB901379_04624(egtB)
MHEK : JMUB5695_00320(egtB_1)
MKY : IWGMT90018_59440(egtB)
MPHL : MPHLCCUG_00352(egtB)
MTHN : 4412656_04308(egtB)
MAUU : NCTC10437_05230(egtB)
MFLV : NCTC10271_00325(egtB)
MSAL : DSM43276_00320(egtB)
MTER : 4434518_03930(egtB)
NFR : ERS450000_05023(egtB)
NAD : NCTC11293_06260(egtB)
NWL : NWFMUON74_10230(egtB)
NSPU : IFM12276_06320(egtB)
RCR : NCTC10994_01625(egtB)
RANT : RHODO2019_07230(egtB)
TPUL : TPB0596_00190(egtB)
SAMB : SAM23877_6629(egtB)
SLE : sle_06840(sle_06840)
SGM : GCM10017557_08710(egtB)
STUI : GCM10017668_06260(egtB)
SGOB : test1122_11460(egtB)
SXT : KPP03845_106341(egtB)
NAQU : ENKNEFLB_01973(egtB)
MSAG : GCM10017556_54340(egtB)
ACTR : Asp14428_55930(egtB)
BALA : DSM104299_01323(egtB)
SBAE : DSM104329_01349(egtB)
» show all
Taxonomy
Reference
Authors
Seebeck FP
Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
Journal
Sequence
Reference
Authors
Pluskal T, Ueno M, Yanagida M
Title
Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
Journal
Other DBs