Entry Name L-cysteinyl-L-histidinylsulfoxide synthase;
Class Oxidoreductases;BRITE hierarchy
Sysname L-histidine,L-cysteine:oxygen [S-(L-histidin-5-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB) L-histidine + L-cysteine + O2 = S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O [RN:
R11015 ]
Reaction(KEGG) Substrate Product S-(L-histidin-5-yl)-L-cysteine S-oxide [CPD:
C20993 ];
H2O [CPD:
C00001 ]
Comment Requires Fe2+ for activity. The enzyme participates in ovothiol biosynthesis. It also has some activity as EC
1.13.11.20 , cysteine dioxygenase, and can perform the reaction of EC
1.14.99.50 , gamma-glutamyl hercynylcysteine sulfoxide synthase, albeit with low activity [4].
History EC 1.14.99.52 created 2015
Reference Authors Braunshausen A, Seebeck FP
Title Identification and characterization of the first ovothiol biosynthetic enzyme.
Journal Reference Authors Song H, Leninger M, Lee N, Liu P
Title Regioselectivity of the oxidative C-S bond formation in ergothioneine and ovothiol biosyntheses.
Journal Reference Authors Mashabela GT, Seebeck FP
Title Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis.
Journal Reference Authors Song H, Her AS, Raso F, Zhen Z, Huo Y, Liu P
Title Cysteine oxidation reactions catalyzed by a mononuclear non-heme iron enzyme (OvoA) in ovothiol biosynthesis.
Journal Other DBs
