KEGG ENZYME: 1.14.99.57

ENZYME: 1.14.99.57

Entry

EC 1.14.99.57               Enzyme

Name

heme oxygenase (mycobilin-producing);
mhuD (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous

Sysname

protoheme,donor:oxygen oxidoreductase (mycobilin-producing)

Reaction(IUBMB)

(1) protoheme + 3 reduced acceptor + 3 O2 = mycobilin a + Fe2+ + 3 acceptor + 3 H2O [RN:R11741];
(2) protoheme + 3 reduced acceptor + 3 O2 = mycobilin b + Fe2+ + 3 acceptor + 3 H2O [RN:R11742]

Reaction(KEGG)

R11741 R11742

Substrate

protoheme [CPD:C00032];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]

Product

mycobilin a [CPD:C21624];
Fe2+ [CPD:C14818];
acceptor [CPD:C00028];
H2O [CPD:C00001];
mycobilin b [CPD:C21625]

Comment

The enzyme, characterized from the bacterium Mycobacterium tuberculosis, is involved in heme degradation and iron utilization. The enzyme binds two stacked protoheme molecules per monomer. Unlike the canonical heme oxygenases, the enzyme does not release carbon monoxide or formaldehyde. Instead, it forms unique products, named mycobilins, that retain the alpha-meso-carbon at the ring cleavage site as an aldehyde group. EC 1.6.2.4, NADPH-hemoprotein reductase, can act as electron donor in vitro.

History

EC 1.14.99.57 created 2017

Orthology

K21481

heme oxygenase (mycobilin-producing)

Genes

ALKL:

MM271_06980

CMIC:

caldi_20900

EUZ:	DVS28_a0730

MTU:	Rv3592(TB11.2)

MTV:

RVBD_3592

MTC:

MT3698

MRA:

MRA_3631

MTF:	TBFG_13625

MTB:	TBMG_03631

MTK:	TBSG_03658

MTZ:	TBXG_003605

MTG:	MRGA327_22160

MTI:	MRGA423_22700

MTE:	CCDC5079_3333

MTUR:

CFBS_3809

MTL:	CCDC5180_3285

MTO:	MTCTRI2_3657(TB11.2)

MTD:	UDA_3592(TB11.2)

MTN:	ERDMAN_3940(TB11.2)

MTJ:	J112_19335

MTUB:

MT7199_3655(TB11.2)

MTUE:

J114_19205

MTX:	M943_18470

MTUL:

TBHG_03533

MTUT:

HKBT1_3794

MTUU:

HKBT2_3803

MTQ:	HKBS1_3806

MBO:	BQ2027_MB3623(mhud)

MBB:	BCG_3657(TB11.2)

MBT:	JTY_3658(TB11.2)

MBM:	BCGMEX_3655

MBK:	K60_037310

MBX:

BCGT_3463

MAF:	MAF_36050(TB11.2)

MMIC:

RN08_3972

MCE:	MCAN_36041(TB11.2)

MCQ:	BN44_110087(TB11)

MCV:	BN43_90093(TB11)

MCX:	BN42_90090(TB11)

MCZ:	BN45_100106(TB11)

MORY:

MO_003751(mhuD)

MLE:

ML1922

MLB:

MLBr01922

MPA:

MAP_0467c

MAO:

MAP4_3400

MAVI:

RC58_16860

MAVU:

RE97_16895

MAV:

MAV_0562

MIT:

OCO_04710

MIA:

OCU_04740

MID:

MIP_00899

MYO:

OEM_04770

MCHI:

AN480_02355

MIR:

OCQ_04870

MMAL:

CKJ54_02285

MLP:

MLM_0706

MMAN:

MMAN_47630

MSA:	Mycsm_05905

MMI:

MMAR_5091

MMAE:

MMARE11_49130

MLI:	MULP_05349

MPSE:

MPSD_52930(TB11.2)

MSHO:

MSHO_05890(mhuD)

MMC:

Mmcs_4751

MKM:

Mkms_4837

MJL:

Mjls_5137

MMM:

W7S_02300

MKN:	MKAN_12340

MYV:	G155_26825

MYE:	AB431_26695

MHAD:

B586_04315

MDX:	BTO20_04175 BTO20_34150

MSHG:

MSG_04590(mhuD)

MFJ:	MFLOJ_40360(mhuD)

MSTO:

MSTO_44320(mhuD)

MSIM:

MSIM_28770(TB11.2)

MSAK:

MSAS_29510

MKU:	I2456_25840(mhuD)

MLW:	MJO58_25255(mhuD)

MXE:	MYXE_04850(mhuD)

MNV:	MNVI_12780(mhuD)

MPAG:

C0J29_28005(mhuD)

MNM:	MNVM_23140(mhuD)

MGOR:

H0P51_25995(mhuD)

MCOO:

MCOO_27650

MBAI:

MB901379_04491(hmoB)

MSEO:

MSEO_34910

MHEK:

JMUB5695_00446(mhuD)

MGAU:

MGALJ_38970

MLJ:	MLAC_46990(TB11.2)

MBRD:

MBRA_19690(TB11.2)

MSHJ:

MSHI_38300(TB11.2)

MMAM:

K3U93_22855(mhuD)

MSPG:

F6B93_20690(mhuD)

MOT:	LTS72_27700(mhuD)

MLM:	MLPF_2438(mhuD)

MPAA:

MKK62_02260(mhuD)

MMEH:

M5I08_21675(mhuD)

MKY:	IWGMT90018_57870(TB11.2)

MADI:

A7U43_06415

MWU:	PT015_15715(mhuD)

MSM:	MSMEG_6086

MSG:	MSMEI_5928

MSB:	LJ00_30100

MSN:	LI99_30105

MSH:	LI98_30110

MVA:

Mvan_5352

MSP:	Mspyr1_47330

MCB:	Mycch_4703

MNE:	D174_27100

MYN:	MyAD_24470

MFT:	XA26_54320

MPHL:

MPHLCCUG_00457(mhuD)

MVQ:

MYVA_5246

MLL:	B1R94_25600

MRH:	MycrhN_2211

MTHN:

4412656_04124(isdG)

MHAS:

MHAS_03809(mhuD)

MDU:	MDUV_48700

MCHT:

MCHIJ_19030

MDR:	MDOR_32750

MAUU:

NCTC10437_05111

MMAG:

MMAD_48910

MMOR:

MMOR_11430

MFX:	MFAL_32330(mhuD)

MAIC:

MAIC_04910

MIJ:	MINS_01000(mhuD)

MALV:

MALV_41740

MTY:	MTOK_21600

MPSC:

MPSYJ_15460

MARZ:

MARA_47080

MGAD:

MGAD_38040

MHEV:

MHEL_27370

MSAR:

MSAR_11250

MANY:

MANY_33360(TB11.2)

MAUB:

MAUB_27460

MPOF:

MPOR_54500

MPHU:

MPHO_42840

MMUC:

C1S78_025840(mhuD)

MMAT:

MMAGJ_33260

MBOK:

MBOE_05480

MFG:	K6L26_04975(mhuD)

MSEI:

MSEDJ_02860

MFLV:

NCTC10271_00429(isdG)

MCEE:

MCEL_37410

MBRM:

L2Z93_000354(mhuD)

MMON:

EWR22_25685

MGO:	AFA91_10340

MHOL:

K3U96_02915(mhuD)

MSEN:

K3U95_25925(mhuD)

MPAE:

K0O64_26205(mhuD)

MRF:	MJO55_24460(mhuD)

MDF:	K0O62_26150(mhuD)

MCRO:

MI149_26505(mhuD)

MGRO:

FZ046_03105(mhuD)

MKR:	MKOR_35130

MPAK:

MIU77_01875

MAB:

MAB_0553c

MMV:	MYCMA_12695

MABB:

MASS_0522

MABL:

MMASJCM_0541

MCHE:

BB28_02610

MIZ:	BAB75_03385

MSTE:

MSTE_00506

MSAO:

MYCSP_02350

MSAL:

DSM43276_00464(mhuD)

MJD:	JDM601_3883

MTER:

4434518_03758(isdG)

MMIN:

MMIN_12780(TB11.2)

MHIB:

MHIB_31450(TB11.2)

MHER:

K3U94_21180(mhuD)

MVM:	MJO54_21075(mhuD)

ASD:

AS9A_0344

CGL:	Cgl2677(Cgl2677) Cgl2991(Cgl2991)

CGB:	cg2962 cg3318

CGU:	WA5_2584 WA5_2889

CGT:	cgR_2579 cgR_2880

CGS:	C624_14690

CGG:	C629_14700

CGM:	cgp_2962 cgp_3318

CGJ:	AR0_12980 AR0_14485

CGQ:	CGLAR1_12845 CGLAR1_14340

CGX:	SB89_14345

CEF:

CE2829

CDI:

DIP1841

CDP:	CD241_1747

CDH:	CDB402_1706

CDT:	CDHC01_1750

CDE:	CDHC02_1746

CDR:	CDHC03_1727

CDA:	CDHC04_1722

CDZ:	CD31A_1839

CDB:	CDBH8_1809

CDS:	CDC7B_1801

CDD:	CDCE8392_1713

CDW:	CDPW8_1813

CDV:	CDVA01_1688

CDIP:

ERS451417_01840

CKP:	ckrop_2015

CPU:	CPFRC_08260

CPL:	Cp3995_1683

CPG:	CP316_08380

CPP:	CpP54B96_1668

CPK:	CP1002_04885

CPQ:	CPC231_08260

CPX:	CPI19_03260

CPZ:	CpPAT10_1641

COR:	Cp267_1706

COP:	CP31_08600

COD:	Cp106_1598

COS:	Cp4202_1630

COI:	CPCIP5297_08390

COE:	CP258_08390

COU:	CP162_08370

CPSE:

CPTA_00011

CPSU:

CPTB_01516

CPSF:

CPTC_02237

CUL:	CULC22_01814

CUC:	CULC809_01715

CUE:	CULC0102_1855

CUN:	Cul210932_1820

CUQ:	Cul210931_1717

CUZ:	Cul05146_1808

CUJ:	CUL131002_1745c

CUS:	CulFRC11_1718

CVA:

CVAR_1807

CHN:	A605_04220

CCN:	H924_12560

CTER:

A606_07295

CMD:	B841_03975

CFN:	CFAL_05065

CCG:	CCASEI_05305

CGY:	CGLY_06810

CAX:	CATYP_10245

CII:	CIMIT_03415

CUV:	CUREI_03640

COA:

DR71_1515

CDO:	CDOO_04200

CHM:	B842_03615

CMQ:	B840_03305

CMV:	CMUST_11805

CTED:

CTEST_03655

CUT:	CUTER_03365

CLW:	CLAC_02365

CDX:	CDES_13505

CSTA:

CSTAT_04615

CCJZ:

ccrud_13535

CFK:	CFRA_11350

CGV:	CGLAU_03670(mhuD)

CSPH:

CSPHI_02215

CAMG:

CAMM_04835

CXE:	FOB82_07670

CEE:	CENDO_03385(mhuD)

CSAN:

E3227_00690

CRF:	FRC0190_01869

CRL:	NCTC7448_00724(isdG)

CPRE:

Csp1_10530(mhuD)

CSUR:

N24_2759 N24_3073

CCYS:

SAMEA4530656_1635

CMAT:

HBA49_03235

CYZ:	C3B44_08110

CANS:

GP473_04080

CPRP:

I6I69_09380

CAMC:

I6I65_09680

CUO:	CUROG_04525(mhuD)

CSIL:

CBE74_09340

CQN:	G7Y29_03135

CCOE:

CETAM_03700(mhuD)

COK:	COCCU_03940(mhuD)

CCYC:

SCMU_36800

CWK:	IA203_03880

CUW:	LH390_04035 LH390_11210

CPOY:

GP475_12055

CACC:

CACC_00825(mhuD)

CFY:	I6L56_10500

CPSP:

L9H27_03730

CHEI:

CHEID_09650(mhuD)

CIHU:

CIHUM_03420(mhuD)

CCOY:

CCOY_03955(mhuD)

CHAD:

CHAD_02565(mhuD)

CFG:	CFREI_13445(mhuD)

CAQM:

CAQUA_08215(mhuD)

CCAW:

CCANI_13550(mhuD)

CAUI:

CAURIS_03425(mhuD)

CFAC:

CFAEC_13185(mhuD)

CFOU:

CFOUR_03250(mhuD)

CATR:

CATRI_03495(mhuD)

CDUR:

CDUR_12890(mhuD)

CHAN:

CHAN_02265(mhuD)

CAFE:

CAFEL_03240(mhuD)

CGF:	CGUA_03980(mhuD1) CGUA_05910(mhuD2)

CAPP:

CAPP_03395(mhuD)

CBRE:

QP027_03000

CRIE:

AK829_06065

BFV:	C628_13260 C628_15075

NFA:

NFA_4270

NFR:	ERS450000_03809

NCY:	NOCYR_0436

NBR:	O3I_002415

NNO:	NONO_c04550

NSL:	BOX37_01960

NSR:	NS506_01207

NTP:	CRH09_03025

NOZ:	DMB37_23365(mhuD)

NOD:	FOH10_29050

NAH:	F5544_02420

NAD:	NCTC11293_01195(isdG)

NWL:	NWFMUON74_04480

NIE:	KV110_02805

NTC:	KHQ06_08465

NHU:	H0264_03575

NYA:	LTV02_29160

NGP:	LTT66_15180(mhuD)

NSPU:

IFM12276_01160

NYU:	D7D52_04230(mhuD)

RHA:	RHA1_ro04436

RER:

RER_06640

REY:

O5Y_03215

REB:	XU06_03450

RQI:	C1M55_03695(mhuD)

ROP:

ROP_43520

ROA:	Pd630_LPD00890

RPY:	Y013_18800

RBY:	CEJ39_05165

RFA:	A3L23_02524(mhuD)

RHS:	A3Q41_00841(mhuD)

RHW:	BFN03_15540

RRZ:	CS378_19155

RHU:	A3Q40_03247(mhuD)

RHQ:	IM25_08650

RHOD:

AOT96_14090

RRT:	4535765_00537(isdG)

RCR:	NCTC10994_02189(isdG)

RTM:	G4H71_07765

RKO:	JWS14_23980

RGO:	KYT97_22745(mhuD)

ROZ:	CBI38_03740

RPSK:

JWS13_20965

RGOR:

NMQ04_02300

RANT:

RHODO2019_14865

RHOP:

D8W71_27145(mhuD)

REQ:

REQ_06210

PDEF:

P9209_29510(mhuD)

WHR:	OG579_09145(mhuD)

GBR:

Gbro_0960

GPO:	GPOL_c42510

GOR:

KTR9_0858

GOQ:	ACH46_17305

GTA:	BCM27_05310

GIT:	C6V83_04090

GRU:	GCWB2_04515(mhuD)

GOM:	D7316_04543(mhuD)

GAV:	C5O27_00615

GOD:	GKZ92_04165

GAM:	GII34_03620 GII34_10995

GPD:	GII33_10570 GII33_19045

GJI:	H1R19_04240

GOI:	LK459_13965

GHN:	MVF96_04460

GAMI:

IHQ52_07110

GMG:	NWF22_06190

GSI:	P5P27_01380

SPIN:

KV203_17780

TPR:

Tpau_0586

TSM:	ASU32_03030

TPUL:

TPB0596_06020

TSD:	MTP03_04830

SRT:

Srot_2179

DTM:	BJL86_1276

DIT:	C3V38_08995

DIZ:	CT688_02930

DPC:	A6048_02850

DLU:	A6035_03145

DKN:	NHB83_02700

TOY:	FO059_03015

SALB:

XNR_4554

SMA:	SAVERM_885

SGR:

SGR_276

SGB:

WQO_33200

SANL:

KZO11_37245

SGRF:

SGFS_080980

SCYE:

R2B67_00505

SCB:	SCAB_65191

SVL:	Strvi_7426

SHY:

SHJG_5366

SHO:	SHJGH_5129

SRC:	M271_33965

SMAL:

SMALA_2283

SSOI:

I1A49_14585

SBH:

SBI_07545

SVE:

SVEN_2050

SDV:	BN159_0670

SCI:	B446_19900

SGU:	SGLAU_18045

SVT:	SVTN_11610

STRE:

GZL_06159

SCW:	TU94_14350

SLD:

T261_5739

SLC:	SL103_07465

SXI:	SXIM_39260

STRM:

M444_11820

SAMB:

SAM23877_6981(mhuD)

SPRI:

SPRI_5160

SCZ:	ABE83_00380

SCX:	AS200_22630

SRW:	TUE45_04065(mhuD)

STRF:

ASR50_16185

SLE:	sle_40240(sle_40240)

STRT:

A8713_16650

SCLF:

BB341_20380

SGS:	AVL59_01710

STSI:

A4E84_01620

SKY:	D0C37_24575

SALW:

CP975_10500

SCAD:

DN051_35215

SPHW:

NFX46_00880

SLS:	SLINC_4430

SNR:	SNOUR_28555

SALU:

DC74_2826

SALL:

SAZ_15505

SAUO:

BV401_14875

SSIA:

A7J05_25180

SVU:	B1H20_33815

SPUN:

BFF78_20290

SGV:	B1H19_13785

SLAU:

SLA_1956

SALF:

SMD44_02580

SALJ:

SMD11_0633

SLX:	SLAV_25545(mhuD)

STRO:

STRMOE7_12555

SFK:

KY5_2409

SNZ:	DC008_02295

SGE:	DWG14_04115(mhuD)

SRJ:

SRO_3500

SLK:	SLUN_11600

SDX:	C4B68_18750

SGD:	ELQ87_13380

SQZ:	FQU76_08440

SCYA:

EJ357_02190

SAST:

CD934_23855

SNQ:	CP978_03815

STIR:

DDW44_05645

SKA:	CP970_30515

SGZ:	C0216_24680

SVN:	CP980_23200

SHAW:

CEB94_02085

SRK:	FGW37_32305

SGAL:

CP966_19205

SSPO:

DDQ41_04640

SVR:	CP971_23670

SPAD:

DVK44_33390

SFY:	GFH48_03635

SAQU:

EJC51_25625

SGF:	HEP81_03712

SCAV:

CVT27_32730

SSEO:

D0Z67_15345

SBY:	H7H31_25815

SRIM:

CP984_28475

SSUB:

CP968_23100

SCIN:

CP977_10565

SPAC:

B1H29_02110

STSU:

B7R87_08375

SCHA:

CP983_02215

SGX:	H4W23_12135

SCOE:

CP976_41055

SBAT:

G4Z16_24720

SSPB:

CP982_13705

SNF:	JYK04_03045(mhuD)

SPLA:

CP981_11830

SBRO:

GQF42_23775

STUI:

GCM10017668_67610

SCHF:

IPT68_19270

SHUN:

DWB77_05373(mhuD)

SHAR:

HUT13_19620

SCYG:

S1361_21205(mhuD)

SFEU:

IM697_21315

SDW:	K7C20_11250

SVD:	CP969_20445

SCAL:

I6J39_33550

SAUH:

SU9_009605

SPRA:

CP972_17500

SPEU:

CGZ69_10500

SROI:

IAG44_35855

SXN:	IAG42_24790

SGJ:	IAG43_09130

SHK:	J2N69_10360

SANU:

K7396_25235

STRY:

EQG64_34075

SDD:	D9753_16690

SACT:

DMT42_20735

SMAO:

CAG99_17940

SGOB:

test1122_05015

SINE:

KI385_14795

SLF:	JEQ17_24520

SDEC:

L3078_13890

SAOV:

G3H79_26235

SDUR:

M4V62_29165

SYAN:

NRK68_10705

SRUG:

F0345_07285

SAKB:

K1J60_31730

STAA:

LDH80_27480

SNIG:

HEK616_11490

SVIO:

HWN34_23010

SCAE:

IHE65_31720

STUB:

MMF93_10195

SSPN:

LXH13_19850

SCIR:

STRCI_007749

SXT:	KPP03845_102566(mhuD)

SLON:

LGI35_15690

STUD:

STRTU_005006

SENG:

OJ254_16400

SGK:	PET44_10440

SANT:

QR300_30230

SYUN:

MOV08_28655

SARG:

HKX69_16325

SJN:	RI060_41610

SCYN:

N8I84_38090

SOV:	QZH56_32605

SHAU:

K9S39_31365

SKG:	KJK29_38405

SCOA:

QU709_20135

SFP:	QUY26_28280

STTN:

BSL84_10415

SINN:

ABB07_18155

STRZ:

OYE22_25100

KSK:

KSE_24270

KAB:	B7C62_34875

KAU:	B6264_18245

KIT:	CFP65_2128

KIS:	HUT16_10265

STRI:

C7M71_007725

YIA:	LO772_34840

AGLA:

OIE69_27260

MIO:	AOA12_17790

MPRT:

ET475_06715

MCHN:

HCR76_14450

MSUW:

GCM10025863_21420

FRP:	AX769_20245

FSB:	GCM10025867_42920

HUW:	FPZ11_15245

GRY:	D7I44_07995

LEU:	Leucomu_03320

LTR:	EVS81_05310

LTN:	KVY00_13055

FRN:	F1C15_05000

SUBT:

KPL76_00240

SUBA:

LQ955_19485

PSEV:

USB125703_01926(mhuD)

GSD:	M3M28_00260

GMN:	GMOLON4_1048(mhuD)

ARL:	AFL94_15870

AAQ:	AOC05_17460

ARY:	ATC04_02070

ARQ:	BWQ92_15060

ACRY:

AC20117_04955

ASUN:

KG104_16675

ASUF:

MNQ99_17165

APOA:

J0916_16230

AWW:	G8758_05135

ACAO:

NF551_15100

AAI:	AARI_32220

GAR:	AOZ07_16575

GCR:	GcLGCM259_2671

GLU:	F0M17_15560

GPR:	JQN66_15875

GMI:	NMP99_16185

GMY:

XH9_09735

GNC:	QQS42_16190

KRH:

KRH_17320

KPL:	KPaMU14_03950

KFV:	AS188_13640

KII:	KocCE7_09255

KRS:	EQG70_06225

KOD:	HBK84_09160

KVR:	CIB50_0001371(mhuD)

MLU:	Mlut_09590

MICK:

B1A86_00004725

MYU:	M8233_04475

MPOR:

KW076_09505

MTEU:

R3I42_02680

RMU:	RMDY18_08470

RDN:	HMPREF0733_12107

RAJ:	RA11412_2055

SATK:

SA2016_3597

AUL:	DCC27_002330 DCC27_011115

AIG:	QDX25_01660 QDX25_11030

CMUA:

P8192_06875

PALU:

CJ193_006115

BFA:	Bfae_30250

BHQ:	BRM3_09540

HMM:	R3I40_07525

JDE:

Jden_0205

KSE:	Ksed_17660

LMOI:

VV02_17955

ALX:	LVQ62_00370

BEI:	GCM100_11780

SKE:	Sked_10750

CELZ:

E5225_15265

CFEN:

KG102_15925

CWN:	NP075_02620

JTE:	ASJ30_12610

JLI:	EXU32_01730

JAY:	H7A72_13020

JCR:	O9K63_08870

BLY:	A2T55_02515

BLIN:

BLSMQ_0403

BRI:	FDF13_12225

BLUT:

EW640_02345

BCAU:

I6G59_05485

BSPO:

L1F31_02240

AUS:	IPK37_15755

GEZ:	FE251_11860

GYU:	FE374_18560

PPC:	HMPREF9154_0543

ARUB:

J5A65_12140

MPH:

MLP_35310

TFA:	BW733_10495

TEJ:	KDB89_02025

BRT:	J4N02_02665

NDK:	I601_3700(mhuD)

NOI:	FCL41_01595

NOO:	FE634_18500

NSN:	EXE58_10085

NARO:

CFH99_21095

NPI:	G7071_08515

NAQU:

ENKNEFLB_00316(mhuD)

NPC:	KUV85_10985

NPS:	KRR39_09130

NMAR:

HPC71_14035

NFC:	KG111_16165

PSIM:

KR76_23480

AER:	AERYTH_12705

AEZ:	C3E78_13140

AEF:	GEV26_13190

ASEZ:

H9L21_03810

ADB:	NP095_03715

AWN:	NQV15_04170

MUZ:	H4N58_04760

TFU:

Tfu_0619

THAO:

NI17_000005

TALX:

FOF52_21010

NDA:

Ndas_3524

NAL:

B005_0659

NGV:	CDO52_22490

NEX:	NE857_26675

NEC:	KGD82_05850

NAKE:

KGD83_07580

NCG:	KGD84_07065

SNAH:

OUQ99_06345

SAIU:

J4H86_23090

TCU:

Tcur_3540

ACTW:

F7P10_33275

SPIQ:

OHA34_32610

ACTQ:

OG417_16345

SRO:

Sros_8033

NOA:	BKM31_53550

NOW:	GBF35_42685

NCX:	Nocox_35070(mhuD)

NGN:	LCN96_47770

NFS:	OIE67_01195

TBI:

Tbis_2807

MHAI:

OHB01_02825

FRA:	Francci3_3811

FRE:	Franean1_0912 Franean1_6639

FAL:	FRAAL1712 FRAAL6064

FSY:	FsymDg_0891

FRI:	FraEuI1c_2656

NML:

Namu_3377

NAKA:

H7F38_21320

GOB:

Gobs_3958

BSD:	BLASA_3736

BLAP:

MVA48_22075

MMAR:

MODMU_4368

KRA:

Krad_1347

SEN:

SACE_0428

SACG:

FDZ84_13935

SVI:	Svir_35390

SACC:

EYD13_19660(mhuD)

AMD:

AMED_8707

AMN:

RAM_44680

AMM:

AMES_8576

AMZ:

B737_8577

AOI:

AORI_7486

AJA:	AJAP_39140

AMQ:	AMETH_6545

AMYC:

CU254_36205

AMYB:

BKN51_30825

AAB:	A4R43_26710

AMYY:

YIM_02735(mhuD)

AORI:

SD37_03055

AACD:

LWP59_36215

APRT:

MUY14_40115

AROO:

NQK81_22570

ATHM:

L1857_34830

ARHD:

VSH64_33370

PDX:

Psed_6110

PSEA:

WY02_14420

PSEE:

FRP1_28025

PSEH:

XF36_26355

PSEQ:

AD006_07205

PECQ:

AD017_15020

PAUT:

Pdca_63610

PBRO:

HOP40_09650

PPEL:

H6H00_10055

APRE:

CNX65_01740

AMI:

Amir_0339

SESP:

BN6_03750

SSYI:

EKG83_01785

KAL:

KALB_5148

KUT:	JJ691_01240

KBU:	Q4V64_49485

KPHY:

AOZ06_02300

LED:	BBK82_12405

AHM:	TL08_01760

ACTI:

UA75_01645

ACAD:

UA74_01640

AHG:	AHOG_01635(mhuD1)

ACTA:

C1701_09365

ALO:

CRK61154

PMAD:

BAY61_28850

SACE:

GIY23_01695

ACTU:

Actkin_00359(hmoB)

CROS:

N8J89_01890

ACTY:

OG774_16150

UME:	RM788_27100

STP:	Strop_0234

SAQ:

Sare_0274

MAU:	Micau_2171

MIL:

ML5_2283

MICB:

MicB006_5237

MTUA:

CSH63_13910

MICH:

FJK98_10115

MTEM:

GCE86_04265

MCAB:

HXZ27_11250

MSAG:

GCM10017556_44590

VMA:	VAB18032_14105

MCRA:

ID554_02890

VER:	HUT12_10250

MENO:

Jiend_08280(mhuD)

MCHL:

PVK74_01645

MFEU:

H1D33_16885

MPRN:

Q3V37_27585

MHAW:

RMN56_01225

ASE:

ACPL_1276

AMS:	AMIS_10590

AFS:

AFR_07130

ACTS:

ACWT_1157

AIH:	Aiant_54790

ACTR:

Asp14428_31830

ACTL:

L3i22_011670 L3i22_011690

ASIC:

Q0Z83_077350(mhuD)

AOU:	ACTOB_001096

PLK:	CIK06_03530

PLAB:

C6361_35760

PLAT:

C6W10_32980

PSUU:

Psuf_094150

PRY:	Prubr_47340

DVC:	Dvina_41665

DFU:	Dfulv_36530

DROS:

Drose_27380

DAUR:

Daura_40335

DMAT:

Dmats_36355

NHY:	JQS43_13845

AUU:	CJ184_006935

ACQ:	AM609_03400

AOS:	AXE84_00560

ARD:	AXF14_00050

ACTO:

C3V41_00890

ANE:	ATCC27039_05140

AHW:	NCTC11636_00020

ASLA:

NCTC11923_01468

AVC:	NCTC10951_00316

AMAS:

QU670_06125

ACAP:

MANAM107_19830

ALIL:

D5R93_08820

FSL:	EJO69_08410

FLH:	EJ997_09675

GHM:	CJ187_001435

AEY:	CDG81_01710

JTL:	M6D93_12795

ABAI:

IMCC26256_11754

BSOL:

FSW04_16600

BALA:

DSM104299_04844(mhuD)

PARN:

NBH00_17595

SBAE:

DSM104329_00316(mhuD)

PBAJ:

LRS13_18725

AYM:	YM304_03210

ATQ:	GH723_06735

AQZ:	KSP35_07700

IAM:	HC251_06195

IMA:	PO878_06525

FYA:	KMW28_17420

» show all

Reference

1 [PMID:19917297]

Authors

Chim N, Iniguez A, Nguyen TQ, Goulding CW

Title

Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis.

Journal

J Mol Biol 395:595-608 (2010)
DOI:10.1016/j.jmb.2009.11.025

Sequence

[mtu:Rv3592]

Reference

2 [PMID:23420845]

Authors

Nambu S, Matsui T, Goulding CW, Takahashi S, Ikeda-Saito M

Title

A new way to degrade heme: the Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO.

Journal

J Biol Chem 288:10101-9 (2013)
DOI:10.1074/jbc.M112.448399

Reference

3 [PMID:24901029]

Authors

Graves AB, Morse RP, Chao A, Iniguez A, Goulding CW, Liptak MD

Title

Crystallographic and spectroscopic insights into heme degradation by Mycobacterium tuberculosis MhuD.

Journal

Inorg Chem 53:5931-40 (2014)
DOI:10.1021/ic500033b

Sequence

[mtu:Rv3592]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.99.57

IUBMB Enzyme Nomenclature:

1.14.99.57

ExPASy - ENZYME nomenclature database:

1.14.99.57

BRENDA, the Enzyme Database:

1.14.99.57

DBGET integrated database retrieval system