KEGG   ENZYME: 1.14.99.59
Entry
EC 1.14.99.59               Enzyme                                 
Name
tryptamine 4-monooxygenase;
PsiH
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
tryptamine,hydrogen-donor:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O [RN:R11912]
Reaction(KEGG)
R11912
Substrate
tryptamine [CPD:C00398];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
4-hydroxytryptamine [CPD:C21762];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin.
History
EC 1.14.99.59 created 2017
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22434  tryptamine 4-monooxygenase
Genes
PCUB: JR316_0010786
Reference
1  [PMID:28763571]
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
  Sequence
[ag:ASU62246]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.59
IUBMB Enzyme Nomenclature: 1.14.99.59
ExPASy - ENZYME nomenclature database: 1.14.99.59
BRENDA, the Enzyme Database: 1.14.99.59

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
Protein domain (5)   
   InterPro (5)   
All databases (27)   

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