Entry
Name
3-demethoxyubiquinol 3-hydroxylase;
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol 5-hydroxylase;
COQ7 (gene name);
clk-1 (gene name);
ubiF (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol,acceptor:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol + a reduced acceptor + O2 = 3-demethylubiquinol + acceptor + H2O [RN:
R12067 ]
Reaction(KEGG)
Substrate
6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol [CPD:
C19859 ];
reduced acceptor [CPD:
C00030 ];
O2 [CPD:
C00007 ]
Product
Comment
The enzyme catalyses the last hydroxylation reaction during the biosynthesis of ubiquinone.
History
EC 1.14.99.60 created 2018
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K03184 3-demethoxyubiquinol 3-hydroxylase
K06134 3-demethoxyubiquinol 3-hydroxylase
Genes
MCF : 102117438 102138856(COQ7)
MTHB : 126945070 126949153
TFN : 117080010 117097596(COQ7)
NCAR : 124962460 124970408
GVR : 103584555 103594412(COQ7)
ZCA : 113925306 113932807(COQ7)
ETF : 101640490(COQ7) 101654257
CUCA : 104054236 104063815(COQ7)
SRX : 107705527 107729533 107740598
SANH : 107658455 107677563
CAUA : 113047060 113088284
CGIB : 127953679 127959884
PTET : 122341818 122346557(coq7)
LROH : 127156825 127166384(coq7)
OMC : 131537718 131542598(coq7)
PPRM : 120489352 120491296(coq7)
RKG : 130097230 130101345(coq7)
CIDE : 127507438 127514917
MASI : 127446484 127450753
CHAR : 105899925 105903454(coq7)
PFOR : 103131731 103131737
PLAI : 106942734 106943024(coq7)
SASA : 100195871(coq7) 106564609
STRU : 115147278 115178313
OMY : 100301840(coq7) 110493493
DSI : Dsimw501_GD16815(Dsim_GD16815)
ACOZ : 120947975 120952927
AARA : 120894938 120906643
AMER : 121589595 121593168
ASTE : 118505416 118514401
AMOU : 128305883 128307004
AALB : 109431071 115255655
PPYR : 116167236 116167784 116170929
DCI : 103510079 103522043 103522045
PPOI : 119089412 119089606 119090360
CBR : CBG_21190(Cbr-clk-1)
BMY : BM_BM7374(Bma-clk-1)
RPHI : 132715031 132722324 132741251
NCS : NCAS_0H02110(NCAS0H02110)
NDI : NDAI_0C01540(NDAI0C01540)
TPF : TPHA_0E01690(TPHA0E01690) TPHA_0J02630(TPHA0J02630)
TBL : TBLA_0A02760(TBLA0A02760)
TDL : TDEL_0D02560(TDEL0D02560)
KAF : KAFR_0D05080(KAFR0D05080)
KNG : KNAG_0B04180(KNAG0B04180)
CAL : CAALFM_C501290CA(CaO19.1940)
NTE : NEUTE1DRAFT87974(NEUTE1DRAFT_87974)
BFU : BCIN_09g01250(Bccat5)
CCAC : CcaHIS019_0702960(COQ7)
SCM : SCHCO_02614858(SCHCODRAFT_02614858)
SMIN : v1.2.018459.t1(symbB.v1.2.018459.t1)
TCR : 508153.170 508183.10
ECOO : ECRM13514_0687(ubiF)
ECOH : ECRM13516_0633(ubiF)
ELR : ECO55CA74_04050(ubiF)
ECW : EcE24377A_0692(ubiF)
EDJ : ECDH1ME8569_0631(ubiF)
ECOI : ECOPMV1_00672(ubiF_1)
SEM : STMDT12_C07340(ubiF)
SETC : CFSAN001921_13675(ubiF)
SEEN : SE451236_09380(ubiF)
SENH : CFSAN002069_05485(ubiF)
SEEH : SEEH1578_12790(ubiF)
SENJ : CFSAN001992_08000(ubiF)
SEEC : CFSAN002050_09970(ubiF)
SEEB : SEEB0189_015925(ubiF)
SENC : SEET0819_10325(ubiF)
REE : electrica_03644(ubiF_2)
RTG : NCTC13098_05341(ubiF_2)
CLAP : NCTC11466_03290(ubiF_2)
KIE : NCTC12125_02319(ubiF_1)
BAGE : BADSM9389_29480(ubiF)
AHN : NCTC12129_03538(ubiF)
PTF : PROFFT_A_02930(ubiF)
PSHI : SAMEA2665130_2230(ubiF_1)
YPG : YpAngola_A1828(ubiF)
YPI : YpsIP31758_2914(ubiF)
SMW : SMWW4_v1c11890(ubiF)
SERS : SERRSCBI_05610(ubiF)
SFJ : SAMEA4384070_1270(ubiF_1)
SOF : NCTC11214_05712(ubiF_4)
SERA : Ser39006_018290(ubiF)
PAQU : DMB82_0014500(ubiF)
DIC : Dpoa569_002577(ubiF)
EHD : ERCIPSTX3056_441(ubiF)
TPTY : NCTC11468_01171(ubiF_2)
PHEI : NCTC12003_02968(ubiF_2)
PRJ : NCTC6933_01069(ubiF_1)
LRI : NCTC12151_02230(ubiF_2)
PDAG : 4362423_01251(ubiF)
ALIG : NCTC10568_02122(ubiF_2)
AVT : NCTC3438_01079(ubiF_2)
PAET : NCTC13378_00319(ubiF)
XFT : PD_0753(coq7) PD_1838(ubiF)
XFM : Xfasm12_0877 Xfasm12_2015
XFN : XfasM23_0790 XfasM23_1938
XFF : XFLM_03645 XFLM_09360
XFL : P303_00660 P303_03710
XFS : D934_10375 D934_13035
XFH : XFHB_04530 XFHB_11150
XTW : AB672_07785 AB672_11335
XCC : XCC0475 XCC0799(visC)
XCA : xcc-b100_0505 xcc-b100_3552
XCV : XCV0522 XCV0908(ubif)
XAX : XACM_0479 XACM_0853(ubif)
XAC : XAC0486 XAC0873(visC)
XCI : XCAW_00898(cAT5) XCAW_03707(visC)
XCT : J151_00609 J151_01000
XCJ : J158_00606 J158_00997
XCU : J159_00606 J159_00997
XCN : J169_00605 J169_00996
XCW : J162_00605 J162_00996
XCR : J163_00605 J163_00996
XCM : J164_00605 J164_00996
XCF : J172_00600 J172_00991
XFU : XFF4834R_chr04850 XFF4834R_chr08760
XAO : XAC29_02485 XAC29_04445
XOM : XOO3530(XOO3530) XOO3930(XOO3930)
XOO : XOO3740(visC) XOO4154(CAT5)
XOP : PXO_04009 PXO_04637(visC)
XOY : AZ54_05200 AZ54_21765
XOZ : BE73_02890 BE73_19780
XSA : SB85_08670 SB85_11135
XTN : FD63_03490 FD63_17880
XFR : BER92_04775 BER92_17945
XVE : BJD12_15080 BJD12_17280
XPE : BJD13_12430 BJD13_14445
XHR : XJ27_11030 XJ27_18345
XGA : BI317_05185 BI317_21275
XPH : XppCFBP6546_07145(XppCFBP6546P_07145) XppCFBP6546_09325(coq7)
XVA : C7V42_02535 C7V42_04735
XAN : AC801_02355 AC801_04415
XAR : XB05_19485 XB05_21215
XHY : FZ025_05005 FZ025_07540(coq7)
XCZ : EBN15_03360 EBN15_16830(coq7)
XTH : G4Q83_16375(coq7) G4Q83_21995
XEU : XSP_000490(coq7) XSP_000859
XHD : LMG31886_05680(COQ7) LMG31886_34700(ubiI)
XPR : MUG10_05710 MUG10_07835(coq7)
XAG : HEP73_03477 HEP73_03964
XDY : NYR95_02945(coq7) NYR95_05050
XAS : HEP74_03286 HEP74_03819
SML : Smlt0826(ubiF) Smlt4303
BUJ : BurJV3_0688 BurJV3_3745
SMZ : SMD_0707(ubiF) SMD_3897
SACZ : AOT14_29390(ubiF_2) AOT14_31560(coq7)
STEK : AXG53_13965 AXG53_15715
SRH : BAY15_0862 BAY15_3457
SLM : BIZ42_08050 BIZ42_12690
STEN : CCR98_03705 CCR98_19110
STEM : CLM74_03680 CLM74_19465
STES : MG068_03390 MG068_19210
SINC : DAIF1_07360(ubiF) DAIF1_38390(coq7)
SPAQ : STNY_R07410 STNY_R39000(coq7)
STEQ : ICJ04_15255 ICJ04_16520(coq7)
SGEN : RKE57_03270 RKE57_19260(coq7)
PSU : Psesu_0330 Psesu_0601
PSUW : WQ53_06095 WQ53_11870
PMEX : H4W19_07445 H4W19_16365(coq7) H4W19_17510
PJP : LAG73_13065 LAG73_14265(coq7)
PDD : MNQ95_04750(coq7) MNQ95_10385
PWI : MWN52_02745(coq7) MWN52_07050
LAB : LA76x_1053 LA76x_4030
LAQ : GLA29479_2099(coq7) GLA29479_3621
LCP : LC55x_4085 LC55x_4401
LGU : LG3211_3885 LG3211_4208
LEZ : GLE_1919 GLE_3903(ubiF) GLE_4263
LMB : C9I47_0672 C9I47_2440
LYT : DWG18_00270 DWG18_10180
LUE : DCD74_01100 DCD74_08585
LYJ : FKV23_12320 FKV23_13920(coq7)
LSOL : GOY17_03350(coq7) GOY17_04570 GOY17_11800
LSX : H8B22_04285(coq7) H8B22_10030
LARE : HIV01_009165 HIV01_010460(coq7)
LHX : LYSHEL_05720(visC) LYSHEL_08980(coq7)
LCAS : LYSCAS_05720(visC) LYSCAS_08980(coq7)
LCIC : INQ41_10640 INQ41_11195(coq7)
LAVI : INQ42_10130 INQ42_10750(coq7)
LLZ : LYB30171_02129(ubiI) LYB30171_02329(coq7)
LAUX : LA521A_06530(coq7) LA521A_08790 LA521A_22910
LYA : RDV84_11720(coq7) RDV84_13465 RDV84_22495
LUM : CNR27_05845 CNR27_14925
LUS : E5843_03385(coq7) E5843_11790
LUG : FPZ22_05205(coq7) FPZ22_10430
THES : FHQ07_05215 FHQ07_06340(coq7)
THEH : G7079_11630 G7079_12725(coq7)
TCN : H9L16_07465(coq7) H9L16_08820
TBV : H9L17_07020(coq7) H9L17_11765
XBC : ELE36_02480(coq7) ELE36_13665
FSG : LQ771_00780(coq7) LQ771_01685
FED : LQ772_01335(coq7) LQ772_02185 LQ772_05930
DTX : ATSB10_13360 ATSB10_24350
LANH : KR767_09350(coq7) KR767_10625
LAEG : L2Y94_17605 L2Y94_18930(coq7)
LAEO : L2Y97_02425(coq7) L2Y97_18405
LAES : L2Y96_02760(coq7) L2Y96_18565
TAMN : N4264_04210(coq7) N4264_06185 N4264_22215
VAU : VANGNB10_cI0838(ubiF)
VSR : Vspart_00972(ubiF_2)
VPL : SA104470976_01805(ubiF_2)
PCI : PCH70_14610 PCH70_46040
PPRC : PFLCHA0_c55700(coq)
PMUD : NCTC8068_04826(coq7)
PFW : PF1751_v1c49790(coq7)
PSK : U771_26465 U771_28730
PFK : PFAS1_00645 PFAS1_14100
PCAM : HNE05_16235 HNE05_20350(coq7)
PTRT : HU722_0026785(coq7)
PTW : TUM18999_07730(coq7) TUM18999_26930
PTAE : NCTC10697_00483(coq7)
PSOA : PSm6_26800(coq7) PSm6_48200
PPAO : K3169_10240 K3169_27375(coq7)
MBS : MRBBS_1254(coq7) MRBBS_3610(ubiF)
MPQ : ABA45_06395 ABA45_16935
KAK : Kalk_07660 Kalk_15365
SCAA : TUM17387_09990(ubiF)
TACT : SG35_019280 SG35_020860
PLZ : S4054249_17805 S4054249_21165
AMC : MADE_1007160 MADE_1009020
AMAA : amad1_07610 amad1_09385
AMAL : I607_06835 I607_08285
AMAE : I876_07125 I876_08560
AMAO : I634_07245 I634_08665
AMAD : I636_07690 I636_09095
AMAI : I635_07595 I635_09365
AMAG : I533_07140 I533_08605
AMAC : MASE_06765 MASE_08215
AMB : AMBAS45_07095 AMBAS45_08805
AMG : AMEC673_06810 AMEC673_08310
LAL : AT746_00475 AT746_07435(ubiF)
CATE : C2869_02510 C2869_18590
SALH : HMF8227_00997(ubiF)
TTU : TERTU_1774 TERTU_3123
HJA : BST95_01105 BST95_01540
PAQM : E0F26_04060(coq7) E0F26_07145
LLG : 44548918_02704(coq7)
LJR : NCTC11533_02870(coq7)
LCJ : NCTC11976_00708(coq7)
LWA : SAMEA4504053_0030(coq7)
LSS : NCTC12082_02055(coq7)
LADL : NCTC12735_00193(coq7)
LANT : TUM19329_03170(coq7)
MPSY : CEK71_16530(ubiF) CEK71_17470
MESL : KKZ03_02160 KKZ03_03290
TSB : HMY34_03255 HMY34_11955(coq7)
RHEI : ATY27_10010(ubiF) ATY27_19645(ubiF)
TLR : Thiosp_03716(coq7) Thiosp_04383(ubiF)
TFRI : Thiofri_03881(coq7) Thiofri_04438(ubiF)
TNI : TVNIR_0364(coq7_[H])
SHAI : LMH63_09405 LMH63_16320
GAI : IMCC3135_11620(ubiI)
THIC : TspCOW1_28640(coq7)
HAHE : ENC22_03080 ENC22_05890
HAHH : O5O45_00765 O5O45_22320
HAK : KO116_01667 KO116_03612
HALO : BWR19_03740 BWR19_18165
HAG : BB497_00450 BB497_15370
HPRO : LMS44_03340 LMS44_14865(coq7)
HALF : QEN58_03235 QEN58_12595(coq7)
HASO : B2G49_11050 B2G49_13060
HASH : HXW73_03435 HXW73_04985(coq7)
HNP : SR894_02925 SR894_13130(coq7)
HTT : HZS52_00505 HZS52_13270(coq7)
KUS : B9G99_06840 B9G99_11910
KMA : B9H00_02940 B9H00_08165
KUY : FY550_00110 FY550_05130(coq7)
ALCA : ASALC70_03266(coq7)
AEL : NCTC12917_01077(ubiF)
SOK : D0B54_00170 D0B54_05990(coq7)
FCE : JN531_003615(coq7) JN531_010695
CDIZ : CEDIAZO_02438(ubiF)
CVI : CV_1132(ubiF) CV_3371
CVC : BKX93_07590 BKX93_18750(ubiF)
CHRO : CXB49_04750 CXB49_16500(ubiF)
CHRI : DK842_01720 DK842_13205(ubiF)
CHRB : DK843_07260 DK843_18660(ubiF)
CRZ : D1345_04025(ubiF) D1345_16265(coq7)
CHRM : FYK34_01285(ubiF) FYK34_11230(coq7)
CHAE : CH06BL_07760 CH06BL_33500(coq7)
AQS : DKK66_03230 DKK66_11405(ubiF)
VOG : LCH97_12400 LCH97_17190(coq7)
REH : H16_A3283(h16_A3283)
BUE : BRPE67_ACDS23750(coq7)
PMEG : FNZ07_07215 FNZ07_30930(coq7)
PDQ : CL55_00001580 CL55_00008390
PCOS : C2747_00850(coq7) C2747_08450
PWU : A8O14_00865 A8O14_09410
PLG : NCTC10937_03213 NCTC10937_04905(coq7)
LIMN : HKT17_09980 HKT17_11515(coq7)
LTO : RGQ30_07610(coq7) RGQ30_21380
BTRM : SAMEA390648701798(coq7)
AXX : ERS451415_05402(coq7)
PVAC : HC248_02961(coq7_1) HC248_03368(coq7_2)
VPE : Varpa_1170 Varpa_2627
LIM : L103DPR2_00664(coq7)
LIH : L63ED372_00267(coq7_1) L63ED372_00529(coq7_2)
HYR : BSY239_3142 BSY239_324
RDP : RD2015_2926 RD2015_957
ATER : MW290_16735(coq7) MW290_23255
RGU : A4W93_05675 A4W93_18995
MASW : AM586_00310 AM586_04995
METR : BSY238_1439 BSY238_2099
URU : DSM104443_00420(coq7)
UPL : DSM104440_00483(coq7)
FPHO : SHINM1_001720(coq7)
ERW : ERWE_CDS_02240(coq7)
ERG : ERGA_CDS_02200(coq7)
RBS : RHODOSMS8_02636(coq7)
BVY : NCTC9239_02911(coq7)
AEX : Astex_0733 Astex_0978
TSV : DSM104635_01909(coq7)
CBOT : ATE48_11545 ATE48_19145
SPHU : SPPYR_0061 SPPYR_0303
SPLM : BXU08_07890 BXU08_16275
SPHC : CVN68_03885 CVN68_13015
SRHI : H9L12_06605 H9L12_09605
SBIN : SBA_ch1_09310(coq7)
SFLA : SPHFLASMR4Y_02518(coq7)
RFL : Rmf_45170(coq7) Rmf_47570
SRF : LHU95_07970 LHU95_14595
ABS : AZOBR_180199 AZOBR_40151
ABQ : ABAZ39_01455 ABAZ39_02420
ABF : AMK58_03570 AMK58_12380
AZT : TSH58p_12990 TSH58p_13950
AARE : D3093_06775 D3093_07745
ELIO : KO353_06890 KO353_13595
» show all
Taxonomy
Reference
Authors
Marbois BN, Clarke CF
Title
The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis.
Journal
Sequence
Reference
Authors
Vajo Z, King LM, Jonassen T, Wilkin DJ, Ho N, Munnich A, Clarke CF, Francomano CA
Title
Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging.
Journal
Sequence
Reference
Authors
Kwon O, Kotsakis A, Meganathan R
Title
Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene.
Journal
Sequence
Reference
Authors
Stenmark P, Grunler J, Mattsson J, Sindelar PJ, Nordlund P, Berthold DA
Title
A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis.
Journal
Sequence
Reference
Authors
Tran UC, Marbois B, Gin P, Gulmezian M, Jonassen T, Clarke CF
Title
Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis.
Journal
Sequence
Other DBs