| Entry |
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| Name |
cyclooctatin synthase;
CotB4
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
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| Sysname |
cyclooctat-9-ene-5,7-diol,hydrogen-donor:oxygen oxidoreductase (18-hydroxylating)
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| Reaction(IUBMB) |
cyclooctat-9-ene-5,7-diol + reduced acceptor + O2 = cyclooctatin + acceptor + H2O [RN: R12178]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Isolated from the bacterium Streptomyces melanosporofaciens M1614-43f2.
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| History |
EC 1.14.99.62 created 2018
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| Pathway |
| ec00997 | Biosynthesis of various other secondary metabolites |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
| SXT: | KPP03845_200298(ptlI) |
| SOV: | QZH56_08935 QZH56_30195 |
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| Reference |
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| Authors |
Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T |
|---|
| Title |
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gorner C, Schrepfer P, Redai V, Wallrapp F, Loll B, Eisenreich W, Haslbeck M, Bruck T |
|---|
| Title |
Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids. |
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| Journal |
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| Other DBs |
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