KEGG   ENZYME: 1.16.1.10
Entry
EC 1.16.1.10                Enzyme                                 
Name
ferric-chelate reductase [NAD(P)H];
ferric reductase (ambiguous)
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
Sysname
Fe(II)-siderophore:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2 Fe(II)-siderophore + NAD(P)+ + H+ = 2 Fe(III)-siderophore + NAD(P)H
Substrate
Fe(II)-siderophore;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H+ [CPD:C00080]
Product
Fe(III)-siderophore;
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).
History
EC 1.16.1.10 created 2014
Orthology
K18915  ferric-chelate reductase [NAD(P)H]
Genes
AFU: AF_0830
AFG: AFULGI_00009160
AST: Asulf_01565
FPL: Ferp_2544
Reference
1  [PMID:10593977]
  Authors
Vadas A, Monbouquette HG, Johnson E, Schroder I
  Title
Identification and characterization of a novel ferric reductase from the hyperthermophilic Archaeon Archaeoglobus fulgidus.
  Journal
J Biol Chem 274:36715-21 (1999)
DOI:10.1074/jbc.274.51.36715
  Sequence
[afu:AF_0830]
Reference
2  [PMID:11525168]
  Authors
Chiu HJ, Johnson E, Schroder I, Rees DC
  Title
Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+.
  Journal
Structure 9:311-9 (2001)
DOI:10.1016/S0969-2126(01)00589-5
  Sequence
[afu:AF_0830]
Other DBs
ExplorEnz - The Enzyme Database: 1.16.1.10
IUBMB Enzyme Nomenclature: 1.16.1.10
ExPASy - ENZYME nomenclature database: 1.16.1.10
BRENDA, the Enzyme Database: 1.16.1.10

  All links  
Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
Protein sequence (10)   
   UniProt (5)   
   SWISS-PROT (2)   
   RefSeq(pep) (3)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (5)   
   InterPro (5)   
All databases (25)   

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