KEGG   ENZYME: 1.16.1.9
Entry
EC 1.16.1.9                 Enzyme                                 
Name
ferric-chelate reductase (NADPH);
ferric chelate reductase (ambiguous);
iron chelate reductase (ambiguous);
NADPH:Fe3+-EDTA reductase;
NADPH-dependent ferric reductase;
yqjH (gene name);
Fe(II):NADP+ oxidoreductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
Sysname
Fe(II)-siderophore:NADP+ oxidoreductase
Reaction(IUBMB)
2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH [RN:R09541]
Reaction(KEGG)
R09541
Substrate
Fe(II)-siderophore;
NADP+ [CPD:C00006];
H+ [CPD:C00080]
Product
Fe(III)-siderophore;
NADPH [CPD:C00005]
Comment
Contains FAD. The enzyme, which is widespread among bacteria, catalyses the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron. The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine [3]. cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].
History
EC 1.16.1.9 created 1992 as EC 1.6.99.13, transferred 2002 to EC 1.16.1.7, transferred 2011 to EC 1.16.1.9, modified 2012, modified 2014
Orthology
K07229  ferric-chelate reductase (NADPH)
Genes
ECO: b3070(nfeF)
ECJ: JW3041(yqjH)
ECD: ECDH10B_3245(yqjH)
EBW: BWG_2780(yqjH)
ECOK: ECMDS42_2539(yqjH)
ECOC: C3026_16770
ECE: Z4423(yqjH)
ECS: ECs_3952(yqjH)
ECF: ECH74115_4383
ETW: ECSP_4044(yqjH)
ELX: CDCO157_3693
EOI: ECO111_3892(yqjH)
EOJ: ECO26_4171(yqjH)
EOH: ECO103_3815(yqjH)
ECOO: ECRM13514_4030(yqjH)
ECOH: ECRM13516_3833(yqjH)
ESL: O3K_03605
ESO: O3O_22040
ESM: O3M_03645
ECK: EC55989_3484(yqjH)
ECG: E2348C_3363(yqjH)
EOK: G2583_3794(yqjH)
ELR: ECO55CA74_18080
ELH: ETEC_3340
ECW: EcE24377A_3535
EUN: UMNK88_3823
ECP: ECP_3160
ENA: ECNA114_3162(ygjH1)
ECOS: EC958_3475(yqjH)
ECV: APECO1_3346(yqjH)
ECOA: APECO78_19155
ECX: EcHS_A3251
ECM: EcSMS35_3364
ECY: ECSE_3351
ECR: ECIAI1_3217(yqjH)
ECQ: ECED1_3738(yqjH)
EUM: ECUMN_3553(yqjH)
ECT: ECIAI39_3566(yqjH)
EOC: CE10_3600(yqjH)
EBR: ECB_02939(yqjH)
ECOB: C3029_19355
EBL: ECD_02939(yqjH)
EBE: B21_02889(yqjH)
EBD: ECBD_0672
ECI: UTI89_C3508(yqjH)
EIH: ECOK1_3502
ECZ: ECS88_3467(yqjH)
ECC: c3823(yqjH)
ELO: EC042_3363
ELN: NRG857_15285
ESE: ECSF_2913
ECL: EcolC_0630
EKO: EKO11_0649
EKF: KO11_07370(yqjH)
EAB: ECABU_c34900(yqjH)
EDH: EcDH1_0631
EDJ: ECDH1ME8569_2965(yqjH)
ELU: UM146_00955
ELW: ECW_m3337(yqjH)
ELL: WFL_16305(yqjH)
ELC: i14_3517(yqjH)
ELD: i02_3517(yqjH)
ELP: P12B_c3187
ELF: LF82_3675(yqjH)
ECOL: LY180_15845
ECOI: ECOPMV1_03388(yqjH)
ECOJ: P423_17345
EFE: EFER_3022(yqjH)
EAL: EAKF1_ch2859
EMA: C1192_19735
ESZ: FEM44_06405(nfeF)
ERUY: OSH18_16255(nfeF)
STY: STY3392
STT: t3134
SEX: STBHUCCB_33110
SENT: TY21A_15865
STM: STM3214(yqjH)
SEO: STM14_3891(yqjH)
SEV: STMMW_32151
SEY: SL1344_3187(yqjH)
SEM: STMDT12_C32720
SEJ: STMUK_3203(yqjH)
SEB: STM474_3368(yqjH)
SEF: UMN798_3496
SETU: STU288_16280
SETC: CFSAN001921_00935
SENR: STMDT2_31071
SEND: DT104_32101
SENI: CY43_16755
SEEN: SE451236_22200
SPT: SPA3082(yqjH)
SEK: SSPA2878
SPQ: SPAB_04010
SEI: SPC_3289(yqjH)
SEC: SCH_3160(yqjH)
SEH: SeHA_C3508
SHB: SU5_03709
SENH: CFSAN002069_16065
SEEH: SEEH1578_02210
SEE: SNSL254_A3474
SENN: SN31241_43430
SEW: SeSA_A3404
SEA: SeAg_B3400
SENS: Q786_15675
SED: SeD_A3570
SEG: SG3110(yqjH)
SEL: SPUL_3226
SEGA: SPUCDC_3212
SET: SEN3056(yqjH)
SENA: AU38_15555
SENO: AU37_15755
SENV: AU39_15755
SENQ: AU40_17530
SENL: IY59_16160
SENJ: CFSAN001992_17465
SEEC: CFSAN002050_23060
SEEB: SEEB0189_003795
SEEP: I137_15395
SENB: BN855_32930
SENE: IA1_15545
SENC: SEET0819_23080
SES: SARI_04415
SBG: SBG_2849
SBZ: A464_3290
SBV: N643_14015
SALZ: EOS98_03220
SFN: SFy_4437
SFS: SFyv_4514
SFT: NCTC1_03370(yqjH_2)
SSN: SSON_3208(yqjH)
SBO: SBO_2929(yqjH)
SBC: SbBS512_E3506
SDY: SDY_3254(yqjH)
SDZ: Asd1617_04341
SHQ: A0259_19095
ENC: ECL_04454
ENL: A3UG_19740
ECLG: EC036_38360
ECLE: ECNIH2_20185
ECLN: ECNIH4_03490 ECNIH4_18155
ECLI: ECNIH5_18765
ECLX: LI66_19470
ECLY: LI62_21430
ECLZ: LI64_18610
ECLO: ENC_33180
EHM: AB284_05940
EXF: BFV63_18970
ECLA: ECNIH3_18855
ECLC: ECR091_18780
EAU: DI57_21520
EKB: BFV64_20325
ENO: ECENHK_19165
EEC: EcWSU1_03884(yqjH)
ELG: BH714_20370
ECAN: CWI88_03080
ERN: BFV67_18970
ECLS: LI67_020855
ECHG: FY206_05660 FY206_21290
ESH: C1N69_19845
EPT: HWQ17_16580
ENT: Ent638_3524
EAS: Entas_3751
ENR: H650_12010
ENX: NI40_019255
ENF: AKI40_0673
LNI: CWR52_15730
EBG: FAI37_09890
END: A4308_03830
ENZ: G0034_19750
ENS: HWQ15_04750
ENK: LOC22_07475
EHU: D5067_0003240
EMOR: L6Y89_19040
ENB: ELK40_19615
EQU: OM418_19150
EPU: QVH39_20075
ESA: ESA_03485
CSK: ES15_3444
CSZ: CSSP291_16180
CSJ: CSK29544_00465
CCON: AFK62_02580
CDM: AFK67_02570
CSI: P262_05163
CMJ: AFK66_017450
CUI: AFK65_02500
CMW: AFK63_16015
CTU: CTU_04810(yqjH)
KPN: KPN_03499(yqjH)
KPU: KP1_4796(yqjH)
KPM: KPHS_46310
KPP: A79E_0618
KPH: KPNIH24_05735
KPZ: KPNIH27_22115
KPV: KPNIH29_23005
KPW: KPNIH30_23330
KPY: KPNIH31_22515
KPG: KPNIH32_24180
KPC: KPNIH10_23065
KPQ: KPR0928_22585
KPT: VK055_3969
KPO: KPN2242_20590
KPR: KPR_4703
KPJ: N559_0673
KPI: D364_18030
KPA: KPNJ1_00661
KPS: KPNJ2_00703
KPX: PMK1_01017(yqjH)
KPB: FH42_13780
KPNE: KU54_003255
KPNU: LI86_03260
KPNK: BN49_0608
KVA: Kvar_0601
KPE: KPK_0613
KPK: A593_07745
KVD: KR75_05010
KVQ: SP68_11645
KOX: KOX_03200
KOE: A225_5090
KOY: J415_06565
KOM: HR38_01790
KMI: VW41_11500
KOK: KONIH1_05845 KONIH1_25745
KOC: AB185_10590
KQU: AVR78_01335
EAE: EAE_03870
EAR: CCG33218
KQV: B8P98_03300
KLL: BJF97_25405
KLW: DA718_03800
KAR: LGL98_03160
KGR: JJJ10_03360
KPAS: LUW96_03125
KLC: K7H21_03390
KLM: BWI76_24615
REE: electrica_00599(yqjH)
ROR: RORB6_21875
RON: TE10_24485
RPLN: B1209_03150
RAO: DSD31_03345
RTG: NCTC13098_00820(yqjH)
CRO: ROD_48101
CKO: CKO_04480
CFD: CFNIH1_02665
CBRA: A6J81_20505
CWE: CO701_01090
CYO: CD187_03165
CPOT: FOB25_14525
CFQ: C2U38_22255
CSED: JY391_03345
CAMA: F384_24655 F384_24710
CAF: AL524_23370
CIF: AL515_20290
CFAR: CI104_03380
CIR: C2U53_02015 C2U53_06105
CIE: AN232_07830
CPAR: CUC49_16015
CTEL: GBC03_01430 GBC03_27565
CITZ: E4Z61_20170
CARS: E1B03_22870
CIX: M4I31_03250
CIB: HF677_003015
CENS: P2W74_02955
EBT: EBL_c04730(yqjH)
CNT: JT31_00830
CEM: LH23_16825
CEN: LH86_15805
CLAP: NCTC11466_02222(yqjH_1)
PGE: LG71_00030 LG71_25630
ESC: Entcl_0639
KLE: AO703_18245
KSA: C813_18645
KOR: AWR26_03110
KRD: A3780_21625
KCO: BWI95_06930
KOT: EH164_02875
KPSE: IP581_20115
KOB: HF650_20805
KOO: O9K67_03310
KGO: CEW81_03370
KIE: NCTC12125_04545(yqjH)
KAS: KATP_05990
KLU: K7B04_08475
KCY: RIN60_03215
LAX: APT61_03165
LEI: C2U54_01555
LEH: C3F35_15105
LEE: DVA44_03160
LER: GNG29_19840
LEA: GNG26_19040
LPNU: KQ929_02610
LEY: DVA43_21180
LAZ: A8A57_18245
LEF: LJPFL01_3620
LEW: DAI21_07820
BUF: D8682_03200
BAGE: BADSM9389_21150
BFT: MNO13_12270
AHN: NCTC12129_00719(yqjH_1)
ASUB: NLZ15_18985
YRE: HEC60_14860
SGOE: A8O29_003730
KIN: AB182_28955
PDZ: HHA33_05660
METY: MRY16398_06890
IZH: FEM41_02445
PSGC: G163CM_42220(yqjH)
SCOL: KFZ77_02660
PVJ: LMA04_09585
SUPE: P0H77_19450
TOE: QMG90_03020 QMG90_16970
EBF: D782_0610
EBC: C2U52_11840
EBU: CUC76_18810
PSTS: E05_39570
RAH: Rahaq_4833
RACE: JHW33_25070
RAQ: Rahaq2_4792
RAA: Q7S_24696
ROX: BV494_23180
RVC: J9880_23835
RBON: QNM34_08565
RIU: I2123_23870
GQU: AWC35_03415
CARU: P0E69_00695
NIG: C1N62_00665
BGJ: AWC36_03685
BIZ: HC231_07685
LBQ: CKQ53_11060
LPOP: I6N93_05960
SOD: Sant_3532
ETA: ETA_13670(yqjH)
EBI: EbC_22530(viuB)
EPE: CI789_04250
ERWI: GN242_07730
ETP: LU633_13065
ERP: LJN55_14980
ETO: RIN69_11475
EGE: EM595_2950(yqjH)
PAM: PANA_3242(yqjH)
PLF: PANA5342_0831(yqjH)
PAJ: PAJ_2467(yqjH)
PAQ: PAGR_g0841
PVA: Pvag_2587(yqjH)
PAGG: AL522_20075
PAO: Pat9b_3261
KLN: LH22_06040
PANT: PSNIH1_02685
PANP: PSNIH2_01560
PAGC: BEE12_03490
PSTW: DSJ_21015
PALH: B1H58_10795
PANS: FCN45_15780
PEY: EE896_03585
PDIS: D8B20_14295
PER: LAC65_13230
PJI: KTJ90_03470
PANO: OJ965_05980
KPIE: N5580_03050
PALF: K6R05_03515
PPHO: CTZ24_12135
PGZ: C2E15_17515
PCD: C2E16_17515
MINT: C7M51_02686(yqjH)
MTHI: C7M52_00168(yqjH)
MHAN: K6958_17095
TCI: A7K98_03840
TPTY: NCTC11468_00709(yqjH)
PFQ: QQ39_00210
CDN: BN940_13611
ACK: C380_01460
ACIO: EAG14_20625
DTS: BI380_23455
DHK: BO996_01410
DLA: I6G47_23840
CTES: O987_25335
CKE: B5M06_03115
AANT: HUK68_18355
DIH: G7047_17040
DUG: HH213_13150
BOT: CIT37_37155
BSYM: CIT39_09870
BARH: WN72_17920
PGA: PGA1_c25930
PGL: PGA2_c23980
PGD: Gal_00838
PHP: PhaeoP97_00167
PPIC: PhaeoP14_02344
PHQ: D1820_07660
LEJ: ETW24_02770
LAQU: R2C4_00495
LCAE: K3721_20440
TPRO: Ga0080559_TMP2424
RMB: K529_016275
CMAG: CBW24_05500
PMAS: NCF86_15990
 » show all
Reference
1  [PMID:18765906]
  Authors
Bamford VA, Armour M, Mitchell SA, Cartron M, Andrews SC, Watson KA
  Title
Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative  cytoplasmic ferri-siderophore reductase.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:792-6 (2008)
DOI:10.1107/S174430910802352X
  Sequence
[eco:b3070]
Reference
2  [PMID:21097627]
  Authors
Wang S, Wu Y, Outten FW
  Title
Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli.
  Journal
J Bacteriol 193:563-74 (2011)
DOI:10.1128/JB.01062-10
  Sequence
[eco:b3070]
Reference
3  [PMID:22098718]
  Authors
Miethke M, Hou J, Marahiel MA
  Title
The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli.
  Journal
Biochemistry 50:10951-64 (2011)
DOI:10.1021/bi201517h
Other DBs
ExplorEnz - The Enzyme Database: 1.16.1.9
IUBMB Enzyme Nomenclature: 1.16.1.9
ExPASy - ENZYME nomenclature database: 1.16.1.9
BRENDA, the Enzyme Database: 1.16.1.9
CAS: 120720-17-4

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Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (463)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (403)   
   KEGG MGENES (32)   
   RefGene (27)   
Protein sequence (7965)   
   UniProt (7144)   
   SWISS-PROT (13)   
   RefSeq(pep) (808)   
DNA sequence (47107)   
   RefSeq(nuc) (39980)   
   GenBank (3680)   
   EMBL (3447)   
Protein domain (11)   
   InterPro (11)   
All databases (55552)   

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