KEGG   ENZYME: 1.16.3.4
Entry
EC 1.16.3.4                 Enzyme                                 
Name
cuproxidase;
cueO (gene name);
cuprous oxidase;
Cu(I) oxidase;
copper efflux oxidase
Class
Oxidoreductases;
Oxidizing metal ions;
With oxygen as acceptor
Sysname
copper(I):oxygen oxidoreductase
Reaction(IUBMB)
4 Cu+ + 4 H+ + O2 = 4 Cu2+ + 2 H2O [RN:R12925]
Reaction(KEGG)
R12925
Substrate
Cu+ [CPD:C22423];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
Cu2+ [CPD:C22424];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Escherichia coli, is involved in copper tolerance under aerobic conditions. The enzyme contains a substrate binding (type 1) copper site and a trinuclear copper center (consisting of type 2 and type 3 copper sites) in which oxygen binding and reduction takes place. It also contains a methionine rich region that can bind additional copper ions. In vitro, if the substrate binding site is occupied by copper(II), the enzyme can function as a laccase-type quinol oxidase (EC 1.10.3.2). However, in vivo this site is occupied by a copper(I) ion and the enzyme functions as a cuprous oxidase.
History
EC 1.16.3.4 created 2021
Orthology
K14588  cuproxidase
Genes
ECOb0123(cueO)
ECJJW0119(cueO)
ECDECDH10B_0103(cueO)
EBWBWG_0116(cueO)
ECOKECMDS42_0114(cueO)
ECOCC3026_00520
ECEZ0133(yacK)
ECSECs_0127(cueO)
ECFECH74115_0130(cueO)
ETWECSP_0124(cueO)
ELXCDCO157_0125
EOIECO111_0124(cueO)
EOJECO26_0125(cueO)
EOHECO103_0123(cueO)
ECOOECRM13514_0125(yacK)
ECOHECRM13516_0128(yacK)
ESLO3K_20950
ESOO3O_04435
ESMO3M_20850
ECKEC55989_0116(cueO)
ECGE2348C_0126(cueO)
EOKG2583_0127(cueO)
ELRECO55CA74_00605
ELHETEC_0119
ECWEcE24377A_0125(cueO)
EUNUMNK88_121
ECPECP_0130
ENAECNA114_0115(yacK)
ECOSEC958_0265(cueO)
ECVAPECO1_1862(cueO)
ECOAAPECO78_04055
ECXEcHS_A0126(cueO)
ECMEcSMS35_0133(cueO)
ECYECSE_0123
ECRECIAI1_0121(cueO)
ECQECED1_0127(cueO)
EUMECUMN_0120(cueO)
ECTECIAI39_0123(cueO)
EOCCE10_0123(cueO)
EBRECB_00122(cueO)
ECOBC3029_04365
EBLECD_00122(cueO)
EBEB21_00121(cueO)
EBDECBD_3496
ECIUTI89_C0136(cueO)
EIHECOK1_0125(cueO)
ECZECS88_0132(cueO)
ECCc0152(yacK)
ELOEC042_0122(cueO)
ELNNRG857_00640
ESEECSF_0136
ECLEcolC_3536
EKOEKO11_3793
EKFKO11_00590(cueO)
EABECABU_c01360(cueO)
EDHEcDH1_3479
EDJECDH1ME8569_0117(cueO)
ELUUM146_23420
ELWECW_m0120(cueO)
ELLWFL_00590(cueO)
ELCi14_0139(yacK)
ELDi02_0139(yacK)
ELPP12B_c0112(cueO)
ELFLF82_0383(cueO)
ECOLLY180_00595
ECOIECOPMV1_00129(cueO)
ECOJP423_00660
EFEEFER_0144(cueO)
EALEAKF1_ch1294c(cueO)
EMAC1192_12345
ESZFEM44_15095(cueO)
ERUYOSH18_09015(cueO)
STYSTY0190(yacK)
STTt0173(yacK)
SEXSTBHUCCB_1930
SENTTY21A_00890
STMSTM0168(cueO)
SEOSTM14_0200(cueO)
SEVSTMMW_01741
SEYSL1344_0169(cueO)
SEMSTMDT12_C01690
SEJSTMUK_0170(cueO)
SEBSTM474_0177(cueO)
SEFUMN798_0187(yacK)
SETUSTU288_00850
SETCCFSAN001921_16570
SENRSTMDT2_01701(yacK)
SENDDT104_01731(yacK)
SENICY43_00845
SEENSE451236_06860
SPTSPA0171(yacK)
SEKSSPA0167
SPQSPAB_00207
SEISPC_0181(yacK)
SECSCH_0168(cueO)
SEHSeHA_C0192
SHBSU5_0810
SENHCFSAN002069_08340
SEEHSEEH1578_09920
SEESNSL254_A0184
SENNSN31241_11570
SEWSeSA_A0187
SEASeAg_B0200
SENSQ786_00890
SEDSeD_A0183
SEGSG0171(cueO)
SELSPUL_0184(cueO)
SEGASPUCDC_0184(cueO)
SETSEN0173(cueO)
SENAAU38_00860
SENOAU37_00860
SENVAU39_00860
SENQAU40_01005
SENLIY59_00885
SENJCFSAN001992_10155
SEECCFSAN002050_07335
SEEBSEEB0189_018500
SEEPI137_00820
SENBBN855_1810(yacK)
SENEIA1_00895
SENCSEET0819_07735
SESSARI_02826
SBGSBG_0160(yacK)
SBZA464_169
SBVN643_00765
SALZEOS98_18370(cueO)
SFLSF0119(yacK)
SFXS0122(yacK)
SFVSFV_0113(yacK)
SFESFxv_0125(cueO)
SFNSFy_0156
SFSSFyv_0160
SFTNCTC1_00123(cueO)
SSNSSON_0131(yacK)
SBOSBO_0112(yacK)
SBCSbBS512_E0116(cueO)
SDYSDY_0030(yacK)
SDZAsd1617_00035
SHQA0259_04450
ENCECL_00928
ENLA3UG_03845
ECLGEC036_07550
ECLEECNIH2_04760
ECLNECNIH4_18935
ECLIECNIH5_03845
ECLXLI66_03855
ECLYLI62_04350
ECLZLI64_03925
ECLOENC_46390
EHMAB284_21125
EXFBFV63_03815
ECLAECNIH3_03835
ECLCECR091_03815
EAUDI57_14750
EKBBFV64_03590
ENOECENHK_04055
EECEcWSU1_00740(cueO)
ELGBH714_18545
ECANCWI88_18335
ERNBFV67_03675
ECLSLI67_004820
ECHGFY206_04500(cueO)
ESHC1N69_03725
EPTHWQ17_08730(cueO)
ENTEnt638_0671
EASEntas_0725
ENRH650_19455
ENXNI40_003685
ENFAKI40_4158
LNICWR52_08380(cueO)
EBGFAI37_02800(cueO)
ENZG0034_03860(cueO)
ENSHWQ15_12260(cueO)
ENKLOC22_14645(cueO)
EHUD5067_0019060(cueO)
EMORL6Y89_03675(cueO)
ENBELK40_04480(cueO)
EQUOM418_03765(cueO)
EPUQVH39_03735(cueO)
ESAESA_03209
CSKES15_3196
CSZCSSP291_14850
CSJCSK29544_00133
CCONAFK62_03830
CDMAFK67_03815
CSIP262_04727
CMJAFK66_015900
CUIAFK65_03765
CMWAFK63_14795
CTUCTU_07620(cueO)
KPNKPN_00131(cueO)
KPUKP1_0957(cueO)
KPMKPHS_08570
KPPA79E_4165
KPHKPNIH24_04310
KPZKPNIH27_04120
KPVKPNIH29_04500
KPWKPNIH30_04530
KPYKPNIH31_03520
KPGKPNIH32_04535
KPCKPNIH10_04295
KPQKPR0928_04305
KPTVK055_2438
KPOKPN2242_03095
KPRKPR_1060(cueO)
KPJN559_4288
KPID364_00615
KPAKPNJ1_04594
KPSKPNJ2_04547
KPXPMK1_02439(cueO)
KPBFH42_21490
KPNEKU54_022215
KPNULI86_22055
KPNKBN49_4209(cueO)
KVAKvar_4251
KPEKPK_4606(cueO)
KPKA593_15065
KVDKR75_12445
KVQSP68_19120
KOXKOX_11130
KOEA225_0935
KOYJ415_26580
KOMHR38_09860
KMIVW41_03640
KOKKONIH1_04865
KOCAB185_31310
KQUAVR78_08885
EAEEAE_11445
EARCCG31694
KQVB8P98_23070
KLLBJF97_05405
KLWDA718_23575(cueO)
KARLGL98_20780(cueO)
KGRJJJ10_23140(cueO)
KPASLUW96_11385(cueO)
KLCK7H21_23285(cueO)
KLMBWI76_04945
REEelectrica_04206(cueO)
RORRORB6_14540
RONTE10_06395
RPLNB1209_22510
RAODSD31_21225
RTGNCTC13098_06152(cueO_3)
CROROD_01341(cueO)
CKOCKO_03244
CFDCFNIH1_10345
CBRAA6J81_12760
CWECO701_17775
CYOCD187_19880
CPOTFOB25_06990(cueO)
CFQC2U38_03985
CSEDJY391_17690(cueO)
CAMAF384_00690
CAFAL524_21805
CIFAL515_05410
CFARCI104_05085
CIRC2U53_04230
CIEAN232_25815
CPARCUC49_00620
CTELGBC03_25170(cueO)
CITZE4Z61_12970(cueO)
CARSE1B03_05160(cueO)
CIXM4I31_19520(cueO)
CIBHF677_019280(cueO)
CENSP2W74_18900(cueO)
EBTEBL_c32300(cueO)
CNTJT31_08630
CEMLH23_09095
CENLH86_09150
CLAPNCTC11466_03798(cueO)
PGELG71_24435
ESCEntcl_3603
KLEAO703_03890
KSAC813_11130
KORAWR26_20855(cueO)
KRDA3780_02885
KCOBWI95_01675
KOTEH164_18400(cueO)
KPSEIP581_03910(cueO)
KOBHF650_04405(cueO)
KOOO9K67_20505(cueO)
KIENCTC12125_02910(cueO)
KASKATP_37500
KLUK7B04_00800(cueO)
KCYRIN60_18785(cueO)
LAXAPT61_18440
LEIC2U54_08905
LEHC3F35_07855
LEEDVA44_19975
LERGNG29_04125(cueO)
LEAGNG26_03615(cueO)
LPNUKQ929_17015(cueO)
LAZA8A57_03830
LEFLJPFL01_0760
LEWDAI21_00575
BUFD8682_11360(cueO)
BAGEBADSM9389_34220
BFTMNO13_20025(cueO)
AHNNCTC12129_00920(cueO)
ASUBNLZ15_18170(cueO)
YREHEC60_21810(cueO)
SGOEA8O29_018935(cueO)
KINAB182_21095
PDZHHA33_23645(cueO)
METYMRY16398_46930(cueO)
IZHFEM41_09815(cueO)
PSHISAMEA2665130_0426(cueO)
PSGCG163CM_27760(cueO)
SCOLKFZ77_03670(cueO)
PVJLMA04_08425(cueO)
SUPEP0H77_04805(cueO)
TOEQMG90_17565(cueO)
EBFD782_3741
EBCC2U52_02745
EBUCUC76_10975
EBBF652_2538(cueO)
PSTSE05_02520
YPEYPO3409(yacK)
YPKy0777
YPHYPC_3739(cueO)
YPAYPA_2911
YPNYPN_0679
YPMYP_0276(sufI1)
YPPYPDSF_2946
YPGYpAngola_A1021(cueO)
YPZYPZ3_3006
YPTA1122_08860
YPDYPD4_2993
YPXYPD8_2993
YPWCH59_2639
YPJCH55_1990
YPVBZ15_113
YPLCH46_1681
YPSYPTB0722(yacK)
YPOBZ17_1833
YPIYpsIP31758_3352(cueO)
YPYYPK_3480
YPBYPTS_0753
YPQDJ40_1650(cueO)
YPUBZ21_4106
YPRBZ20_1363
YPCBZ23_199
YPFBZ19_72
YENYE0712(yacK)
YEPYE105_C0827
YEYY11_39441
YELLC20_04449
YEWCH47_2773(cueO)
YETCH48_895
YEFFORC2_3386
YEEYE5303_26271(yacK)
YSIBF17_11895
YALAT01_3237
YFRAW19_4049(cueO)
YINCH53_984(cueO)
YKRCH54_1741
YROCH64_3333
YRUBD65_2590(cueO)
YRBUGYR_13330
YAKACZ76_12675
YMADA391_18475
YHID5F51_04420(cueO)
YCAF0T03_02120(cueO) F0T03_04145(cueO)
YMOHRD69_09310(cueO)
YASN0H69_03810(cueO)
YKIHRD70_06535(cueO) HRD70_08460(cueO)
YEGPL78_14170
SMARSM39_3597(cueO)
SMACSMDB11_3411(cueO)
SMWSMWW4_v1c41080(cueO)
SPESpro_3999
SRRSerAS9_4206
SRLSOD_c39520(cueO)
SRYM621_21220
SPLYQ5A_021185(cueO)
SRSSerAS12_4207
SRASerAS13_4207
SMAFD781_3724
SLQM495_20865
SERFL085_07965
SERSSERRSCBI_19975
SFWWN53_02785
SFGAV650_25515
SRZAXX16_1363
SERMCLM71_19435
SQUE4343_20380(cueO)
SFJSAMEA4384070_4119(cueO)
SOFNCTC11214_02620(cueO_1)
SSURATE40_017260
SURIJ0X03_03365(cueO)
SRHZFO014_14715(cueO)
SENPKHA73_20100(cueO)
SNEMNLX84_20860(cueO)
SNEVOI978_10830(cueO)
SFOZ042_07180
RAHRahaq_3685
RACEJHW33_12625(cueO)
RAQRahaq2_3779
RAAQ7S_18765
ROXBV494_13260
RVCJ9880_03975(cueO)
RBONQNM34_18745(cueO)
RIUI2123_03925(cueO) I2123_20025(cueO)
GQUAWC35_15960
EAMEGXP68_17275(cueO)
RBADH2866_11330(cueO)
RCBO1V66_14210(cueO)
NIGC1N62_14080
SERASer39006_015515
SERQCWC46_15510
DDDDda3937_00009(cueO)
DZEDd1591_2296
DDCDd586_2229
DZCW909_08850
DSOA4U42_18850
CEDLH89_02470
DFNCVE23_10310
DDQDDI_1766
DAQDAQ1742_02125(cueO)
DICDpoa569_002062(cueO)
DLCO1Q98_00995(cueO)
DDADd703_2196
EAMEAMY_2803(yacK)
EAYEAM_0777(cueO)
ETAETA_08330(cueO)
EPYEpC_08230(cueO)
EPREPYR_00868(yacK)
EBIEbC_07740(cueO)
ERJEJP617_02700(yacK)
EPECI789_14625
ERWIGN242_17370(cueO)
ETPLU633_04840(cueO)
ERPLJN55_19060(cueO)
ETORIN69_04380(cueO)
EGEEM595_0771(cueO)
PAMPANA_0758(cueO)
PLFPANA5342_3549(cueO)
PAJPAJ_0106(cueO)
PAQPAGR_g3440
PVAPvag_0170(yacK)
PAGGAL522_07790
PAOPat9b_0716
KLNLH22_18665
PANTPSNIH1_08540
PANPPSNIH2_14210
PAGCBEE12_10520
PALHB1H58_03260
PANSFCN45_03610(cueO)
PEYEE896_15750(cueO)
PDISD8B20_03475(cueO)
PERLAC65_02730(cueO)
PJIKTJ90_15610(cueO)
PANOOJ965_17495(cueO)
KPIEN5580_14990(cueO)
PALFK6R05_15340(cueO)
PPHOCTZ24_03710
PGZC2E15_04545
PCDC2E16_04475
MINTC7M51_00088(cueO)
MTHIC7M52_02628(cueO)
MHANK6958_04215(cueO)
TCIA7K98_16035
TPTYNCTC11468_03055(cueO)
PLUplu0845(cueO)
PLUMA4R40_04225
PAYPAU_00797(cueO)
PAKHB0X70_04650
PLUICE143_04580
PMRPMI0159(cueO)
PMIBBB2000_0323(cueO)
PVLAOB99_03610
PVGCRN77_00410
PHAUPH4a_10830
PROTBTA34_02510
PCOLF1325_03770(cueO)
PCIBF9282_03590(cueO)
PPEEI6G31_05705(cueO)
PSIS70_05215
PSXDR96_155(cueO)
PSTABGK56_08090
PTHAOI982_18580(cueO)
PRGRB151_034280(cueO)
PALACO695_09185
PHEINCTC12003_01021(cueO)
PRQCYG50_21330(cueO)
PRJNCTC6933_03024(cueO)
PVCG3341_05000(cueO)
PMAGJI723_05350(cueO)
PHAGPZ638_04985(cueO)
MMKMU9_1116
ANSArsFIN_36830(cueO_2)
AETLDL57_03220(cueO)
AAPCQG404_11850(cueO)
HAVAT03_17850
HPARAL518_08650
OPODSM2777_07395
MIIBTJ40_18080
MICTFIU95_16880(cueO)
MVBMJO52_17190(cueO)
AHAAHA_3589
AHYAHML_18985
AHDAI20_01415
AHRV428_19735
AHPV429_19765
AHJV469_03545
AHHRY45_18430
AHIVU14_03750
AAJBOQ57_18735
ADHCK627_22375
SALVSALWKB2_1479
PEWKZJ38_34310(cueO)
AMIMMIM_c31520(cueO)
BMEBMEII0580
BMELDK63_2666(cueO)
BMIBMEA_B0678
BMZBM28_B0672
BMGBM590_B0671
BMWBMNI_II0655
BMEEDK62_2736(cueO)
BMFBAB2_0534
BMBBruAb2_0526
BMCBAbS19_II05050
BAABAA13334_II01075
BABODK55_2514(cueO)
BABRDO74_2929(cueO)
BABTDK49_2725(cueO)
BABBDK48_2177(cueO)
BABUDK53_2517(cueO)
BABSDK51_3101(cueO)
BABCDO78_2541(cueO)
BMSBRA0704
BSIBS1330_II0697
BSFBSS2_II0669
BSUIBSSP1_II0645
BSUPBSPT1_II0642
BSUVBSPT2_II0645
BSUCBSSP2_II0654
BMTBSUIS_B0689
BSZDK67_2669(cueO)
BSVBSVBI22_B0696
BSWIY71_14550
BSGIY72_14505
BOVBOV_A0660
BCSBCAN_B0707
BSKBCA52141_II0227
BOLBCOUA_II0704
BCARDK60_2404(cueO)
BCASDA85_13840
BMRBMI_II698
BPPBPI_II758
BPVDK65_2933(cueO)
BCETV910_200565
BCEEV568_200645
BVLBF3285c2_0235
BRUBFS01_12930
BRJBKD03_03210
OINIAR37_17165(cueO)
BIOBR141012304_20323
OANOant_3828
OAHDR92_2663(cueO)
OPSA8A54_14650
BPSNNIK97_19885(cueO)
OCHCES85_4087
OCRHGK82_21610(cueO)
OCLGTN27_16285(cueO)
MSLMsil_2277
THDBHV28_08930
DEXHWD60_14670(cueO)
DOGHP555_08250(cueO)
 » show all
Reference
1  [PMID:11466290]
  Authors
Kim C, Lorenz WW, Hoopes JT, Dean JF
  Title
Oxidation of phenolate siderophores by the multicopper oxidase encoded by the Escherichia coli yacK gene.
  Journal
J Bacteriol 183:4866-75 (2001)
DOI:10.1128/JB.183.16.4866-4875.2001
Reference
2  [PMID:11527384]
  Authors
Grass G, Rensing C.
  Title
CueO is a multi-copper oxidase that confers copper tolerance in Escherichia coli.
  Journal
Biochem Biophys Res Commun 286:902-8 (2001)
DOI:10.1006/bbrc.2001.5474
  Sequence
[eco:b0123]
Reference
3  [PMID:11399769]
  Authors
Outten FW, Huffman DL, Hale JA, O'Halloran TV
  Title
The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.
  Journal
J Biol Chem 276:30670-7 (2001)
DOI:10.1074/jbc.M104122200
Reference
4  [PMID:11867755]
  Authors
Roberts SA, Weichsel A, Grass G, Thakali K, Hazzard JT, Tollin G, Rensing C, Montfort WR.
  Title
Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 99:2766-71 (2002)
DOI:10.1073/pnas.052710499
  Sequence
[eco:b0123]
Reference
5  [PMID:12794077]
  Authors
Roberts SA, Wildner GF, Grass G, Weichsel A, Ambrus A, Rensing C, Montfort WR.
  Title
A labile regulatory copper ion lies near the T1 copper site in the multicopper oxidase CueO.
  Journal
J Biol Chem 278:31958-63 (2003)
DOI:10.1074/jbc.M302963200
  Sequence
[eco:b0123]
Reference
6  [PMID:15516598]
  Authors
Singh SK, Grass G, Rensing C, Montfort WR.
  Title
Cuprous oxidase activity of CueO from Escherichia coli.
  Journal
J Bacteriol 186:7815-7 (2004)
DOI:10.1128/JB.186.22.7815-7817.2004
Reference
7  [PMID:14648285]
  Authors
Galli I, Musci G, Bonaccorsi di Patti MC.
  Title
Sequential reconstitution of copper sites in the multicopper oxidase CueO.
  Journal
J Biol Inorg Chem 9:90-5 (2004)
DOI:10.1007/s00775-003-0501-4
Reference
8  [PMID:20088522]
  Authors
Djoko KY, Chong LX, Wedd AG, Xiao Z.
  Title
Reaction mechanisms of the multicopper oxidase CueO from Escherichia coli support its functional role as a cuprous oxidase.
  Journal
J Am Chem Soc 132:2005-15 (2010)
DOI:10.1021/ja9091903
  Sequence
[eco:b0123]
Reference
9  [PMID:21903583]
  Authors
Singh SK, Roberts SA, McDevitt SF, Weichsel A, Wildner GF, Grass GB, Rensing C, Montfort WR.
  Title
Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence.
  Journal
J Biol Chem 286:37849-57 (2011)
DOI:10.1074/jbc.M111.293589
  Sequence
[eco:b0123]
Reference
10 [PMID:25679350]
  Authors
Cortes L, Wedd AG, Xiao Z.
  Title
The functional roles of the three copper sites associated with the methionine-rich insert in the multicopper oxidase CueO from E. coli.
  Journal
Metallomics 7:776-85 (2015)
DOI:10.1039/c5mt00001g
  Sequence
[eco:b0123]
Other DBs
ExplorEnz - The Enzyme Database: 1.16.3.4
IUBMB Enzyme Nomenclature: 1.16.3.4
ExPASy - ENZYME nomenclature database: 1.16.3.4
BRENDA, the Enzyme Database: 1.16.3.4

DBGET integrated database retrieval system