KEGG ENZYME: 1.17.1.10

ENZYME: 1.17.1.10

Entry

EC 1.17.1.10                Enzyme

Name

formate dehydrogenase (NADP+);
NADP+-dependent formate dehydrogenase

Class

Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor

Sysname

formate:NADP+ oxidoreductase

Reaction(IUBMB)

formate + NADP+ = CO2 + NADPH [RN:R00134]

Reaction(KEGG)

R00134

Substrate

formate [CPD:C00058];
NADP+ [CPD:C00006]

Product

CO2 [CPD:C00011];
NADPH [CPD:C00005]

Comment

A tungsten-selenium-iron protein characterized from the bacterium Moorella thermoacetica. It is extremely sensitive to oxygen.

History

EC 1.17.1.10 created 1978 as EC 1.2.1.43, transferred 2017 to EC 1.17.1.10

Pathway

ec00680

Methane metabolism

ec00720

Carbon fixation pathways in prokaryotes

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K05299

formate dehydrogenase (NADP+) alpha subunit

K15022

formate dehydrogenase (NADP+) beta subunit

Genes

VFU:	vfu_A02711

VGA:	BSQ33_17050

VSR:	Vspart_03926(gltD_2)

TIG:

THII_3690

TNI:	TVNIR_2014

TTI:	THITH_06945

ATY:	A9R16_007295

LHK:

LHK_02330

CCAX:

KZ686_11545(fdhF)

SUTT:

SUTMEG_16550

SUTK:

FG381_03580

SWS:	I6J16_02780

BBAY:

A4V04_04855

DDZ:	DSYM_19100

RPA:	TX73_000695

RPE:

RPE_3861

RPT:

Rpal_0138

RPX:	Rpdx1_0129

BVR:

BVIR_2956

BLAG:

BLTE_01210

RHC:

RGUI_3847

RAP:

RHOA_1103

MAGQ:

MGMAQ_1747

HBL:	XJ32_06675

WSU:	WS0477(FDHB)

TDN:	Suden_1824

SUA:

Saut_1830

SULN:

FJR47_08390

SULG:

FJR48_10415

SULC:

CVO_01175

SPAL:

FM071_08755

SSEI:

FJR45_10385

SBAL:

HUE88_01240

SMAS:

HUE87_10880

SMAX:

FJR03_09560

SKU:	Sulku_0269

SULR:

B649_01165

HYO:

NNO_1954

HTM:	RZR91_01580

HCJ:	HCR_15980(sfrB)

NSA:	Nitsa_0162

SUN:

SUN_2227

SLH:	YH65_00465

SINU:

IMZ28_01145

SMAB:

LN246_12055

NIS:

NIS_0293

GSU:	GSU0509(sfrA) GSU0510(sfrB)

GSK:	KN400_0498(sfrA) KN400_0499(sfrB)

GME:	Gmet_3022(sfrA) Gmet_3023(sfrB)

GPI:	GPICK_13835 GPICK_13840

GBZ:	JZM60_03195 JZM60_03200

GEM:	GM21_0672 GM21_0673

GEB:	GM18_3695 GM18_3696

GEF:	FO488_01565

GUR:	Gura_3639 Gura_3640

GEO:	Geob_1607(sfrB) Geob_1608(sfrA)

GLO:	Glov_0660 Glov_0661

TAMM:

GEAMG1_0198(sfrA) GEAMG1_0199(sfrB)

GBM:	Gbem_0659(sfrB) Gbem_0660(sfrA)

GBN:	GEOBRER4_06660(sfrB) GEOBRER4_06670(sfrA) GEOBRER4_30170

GER:	KP004_02570 KP004_02575

GSUB:

KP001_12875 KP001_12880

GNT:	KP003_02205 KP003_02210

GPL:	M1B72_18390 M1B72_18395

GSB:	GSUB_01595 GSUB_01600

GHC:	L9S41_11600 L9S41_11605

PCA:	Pcar_2503(sfrB)

DEU:	DBW_0666 DBW_0667

DVE:	DESUT3_04340(sfrB) DESUT3_04350(sfrA)

DEP:	AOP6_2711(sfrA) AOP6_2712(sfrB)

DES:	DSOUD_3426 DSOUD_3427

DDS:

Ddes_1543

DEF:	CNY67_05260

PSYF:

N1030_00160(fdhF)

DSA:	Desal_0925 Desal_1735

DHY:	DESAM_22464 DESAM_23223

DAF:	Desaf_1699

DAS:

Daes_1334

DPI:	BN4_10151 BN4_10592

DEJ:	AWY79_10930 AWY79_17585

PPRF:

DPRO_0175 DPRO_0998

PSEL:

GM415_12865

DDN:	DND132_0178 DND132_0691 DND132_2868

PSEF:

PSDVSF_06760

PPOR:

JCM14722_04400 JCM14722_09200

PNW:	SYK_05490 SYK_08600 SYK_15590

PTHE:

LF599_02925 LF599_10600

DVU:

DVU_1772

DVL:

Dvul_1383

DVG:	Deval_1526

DBA:

Dbac_0167

DESU:

NLA06_12110(fdhF)

DPS:

DP0682

DBK:	DGMP_17720

DDU:

GF1_09750

DOL:

Dole_2825

DAL:	Dalk_0215 Dalk_2557 Dalk_2596 Dalk_2597

DAT:	HRM2_16890(fdhA6) HRM2_26590(gltD1) HRM2_32120

DTO:	TOL2_C10170(rnfB) TOL2_C28850(fdhA2)

DOV:	DSCO28_46070 DSCO28_50930(sfrB) DSCO28_53000 DSCO28_60770

DWD:	DSCW_19530 DSCW_24100 DSCW_39410

DALK:

DSCA_31580 DSCA_39350 DSCA_49620 DSCA_51850 DSCA_56540

DML:	Dmul_27610(rnfB2)

DMM:	dnm_034450 dnm_072420(rnfB2) dnm_095740

DEK:	DSLASN_10670

DAO:	Desac_1071 Desac_2111

DTI:	Desti_0863 Desti_2930 Desti_2931

SFU:

Sfum_1181

DAX:	FDQ92_14530 FDQ92_14660

DBR:	Deba_0487 Deba_0488 Deba_1743

DMP:	FAK_07840 FAK_16570

TAV:	G4V39_01635

TMAI:

FVE67_00210

ADE:

Adeh_2406

DHR:	LGS26_01895(fdhF)

CLJ:	CLJU_c08690

CAH:	CAETHG_2963

CDRK:

B9W14_11420

CMIC:

caldi_03270

DSY:	DSY3968(fdhF)

DHD:

Dhaf_1398

DDH:	Desde_1318

DDL:	Desdi_1184

SGY:

Sgly_2685

DOR:	Desor_0661 Desor_4477

DAI:	Desaci_0777

DMI:	Desmer_0214 Desmer_0713

DED:	DHBDCA_p1614

DEC:	DCF50_p1622

DRS:	DEHRE_11885

DCA:	Desca_2053

DAE:	Dtox_3503 Dtox_3507

DAU:

Daud_0104

FWA:	DCMF_14065

AACX:

DEACI_1377

TJR:	TherJR_0670 TherJR_0942

DGI:	Desgi_2136 Desgi_3847

HMO:	HM1_1745(fdhA)

AWI:	CHL1_000121(fdhF)

CTHM:

CFE_2215

CHY:	CHY_0733(fdhA)

ADG:	Adeg_0156 Adeg_0334

MTA:	Moth_2312(fdhA) Moth_2314

MTHO:

MOTHE_c23870(fdhF3) MOTHE_c23890(sfrB2)

MTHZ:

MOTHA_c24590(fdhF3) MOTHA_c24610(sfrB2)

TOC:

Toce_0785

NTH:	Nther_0100

AAR:	Acear_2299

CAD:	Curi_c16640(fdhB)

KPAR:

JL105_10655(fdhF)

DET:

DET0123

DEV:

DhcVS_131

DMG:

GY50_0154

DMX:	X792_00790

DMY:	X793_00645

DUC:	UCH007_01080

DLY:	Dehly_0151 Dehly_0227 Dehly_1357

DEW:	DGWBC_1766

DFO:	Dform_02183

DETH:

HX448_07080(fdhF)

KBB:	ccbrp13_10910

ULI:	ETAA1_06170

KST:	KSMBR1_3796

BROC:

IPI25_00230 IPI25_04935 IPI25_07710(fdhF) IPI25_08630(fdhF) IPI25_10400

BPIT:

BPIT_05580 BPIT_26950

JET:	L3J17_07505 L3J17_14530(fdhF)

ADIN:

H7849_06915(nuoG)

SUS:

Acid_3510

PFER:

IRI77_15560

ARAM:

KAR29_00265(fdhF)

ASAC:

ATHSA_0203

DDF:	DEFDS_1613

DAP:	Dacet_2494

GTL:	EP073_00480

CNI:	Calni_1870

FSI:	Flexsi_0433

MSCH:

N508_001026(sfrA) N508_001027(sfrB)

DTP:	JZK55_05530(nuoG-1_1) JZK55_11790 JZK55_19460(fdhA)

NKF:	Nkreftii_003503 Nkreftii_004097

NTI:	DNFV4_00402 DNFV4_00911

NALL:

PP769_05445 PP769_08770(nuoG)

NNEO:

PQG83_16650 PQG83_19995(nuoG)

NLI:	G3M70_15040

NVA:	G3M78_09375

MOX:

DAMO_0766

MTH:

MTH_1552

MMG:	MTBMA_c01380(fdhA1)

MTEE:

MTTB_15350

METC:

MTCT_1417

METE:

tca_01501(fdhF_2)

METZ:

METMT2_0015

METK:

FVF72_03860

METJ:

FZP68_05395

MEL:	Metbo_2515

METT:

CIT01_06250

MEME:

HYG87_07080(fdhF)

MFEG:

GCM10025860_09010

MTP:

Mthe_0915

BARB:

AOA66_1514(sudA_1)

LOB:	NEF87_003197

» show all

Reference

1 [PMID:4154039]

Authors

Andreesen JR, Ljungdahl LG.

Title

Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties.

Journal

J Bacteriol 120:6-14 (1974)
DOI:10.1128/JB.120.1.6-14.1974

Reference

2 [PMID:6822536]

Authors

Yamamoto I, Saiki T, Liu SM, Ljungdahl LG

Title

Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein.

Journal

J Biol Chem 258:1826-32 (1983)

Other DBs

ExplorEnz - The Enzyme Database:

1.17.1.10

IUBMB Enzyme Nomenclature:

1.17.1.10

ExPASy - ENZYME nomenclature database:

1.17.1.10

BRENDA, the Enzyme Database:

1.17.1.10

CAS:	51377-43-6

DBGET integrated database retrieval system