KEGG   ENZYME: 1.17.1.11
Entry
EC 1.17.1.11                Enzyme                                 
Name
formate dehydrogenase (NAD+, ferredoxin);
electron-bifurcating formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
Sysname
formate:NAD+, ferredoxin oxidoreductase
Reaction(IUBMB)
2 formate + NAD+ + 2 oxidized ferredoxin [iron-sulfur] cluster = 2 CO2 + NADH + H+ + 2 reduced ferredoxin [iron-sulfur] cluster [RN:R11818]
Reaction(KEGG)
R11818
Substrate
formate [CPD:C00058];
NAD+ [CPD:C00003];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Product
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138]
Comment
The enzyme complex, isolated from the bacterium Gottschalkia acidurici, couples the reduction of NAD+ and the reduction of ferredoxin with formate via flavin-based electron bifurcation.
History
EC 1.17.1.11 created 2015 as EC 1.2.1.93, transferred 2017 to EC 1.17.1.11
Orthology
K22338  formate dehydrogenase (NAD+, ferredoxin) subunit A
K22339  formate dehydrogenase (NAD+, ferredoxin) subunit B
K22340  formate dehydrogenase (NAD+, ferredoxin) subunit C
K22341  formate dehydrogenase (NAD+, ferredoxin) subunit
Genes
PCA: Pcar_1843(fdnG)
PPD: Ppro_3520
DDU: GF1_14240
DEK: DSLASN_08690 DSLASN_10680 DSLASN_45330
DMP: FAK_27460
PTJ: JRJ22_12790(nuoE)
ERAF: J9537_09245
EMS: P3T75_07420
CACE: CACET_c32690(fdhA) CACET_c32720 CACET_c35730(nuoF2) CACET_c35750(nuoE2)
CFM: BJL90_01750 BJL90_01760 BJL90_01770 BJL90_01775 BJL90_01790
CALD: PWK10_05315(nuoE)
CRS: FQB35_03900
CPRF: K7H06_03100(nuoE) K7H06_03120
CRAS: KVH43_01540
HHJ: NQ487_25755
OCW: OW730_18895(nuoF) OW730_18905(nuoE)
PROQ: P6M73_09200(fdhF) P6M73_09205 P6M73_09210 P6M73_09215 P6M73_13470
RGV: NQ502_01455
ACOL: K5I23_04465
LASA: L9O85_09695(nuoF) L9O85_09705
PETR: QKW49_00165 QKW49_20015
PALM: RBG61_01775
CFEM: HCR03_14560
AMUR: ADH66_14115
DCA: Desca_1018
TFR: BR63_18185
AWI: CHL1_000122(nuoF) CHL1_000124 CHL1_000618(fdhF) CHL1_000832
ALKA: J0B03_08020(fdhF)
ALAC: JYE50_07310(nuoF) JYE50_07325(nuoE)
AHC: JYE49_07305(nuoF) JYE49_07320(nuoE)
FMS: M1R53_01010
PROM: QO263_02365(fdhF) QO263_02370 QO263_02375(nuoF) QO263_02385
CBAF: JS518_02070(nuoE) JS518_02085(nuoF)
BHV: BLHYD_15520(hndA_1) BLHYD_17890(napA_2)
CHYL: CE91St63_25510(hymA)
LXA: OW255_17355
ACHT: bsdcttw_47930
CASP: NQ535_07155
MFOR: NQ534_19380
AHB: bsdtb5_32690
CBIL: EUBC25_21310(hymA)
LBX: lbkm_3450
VPY: HZI73_06735(fdhF)
MNL: QU661_05100
ETM: CE91St48_32100
AMT: Amet_4102 Amet_4108 Amet_4110
AOE: Clos_2249 Clos_2250 Clos_2251 Clos_2252
GFE: Gferi_20690 Gferi_20700 Gferi_20760
CSPO: QNI18_01050(nuoF) QNI18_01060(nuoE)
TEB: T8CH_1955(hndC) T8CH_1957(hndA) T8CH_2291(hndA) T8CH_2292 T8CH_3078(hndC) T8CH_3079(hndA)
THYR: P4S50_01015(nuoE) P4S50_01020(nuoF) P4S50_05745 P4S50_05750
EAC: EAL2_c04290(hymA) EAL2_c04300(hymB) EAL2_c04330(fdhB1) EAL2_c04340(fdhA1) EAL2_c20470(fdhA2)
NCD: ACONDI_00243 ACONDI_02924(fdhF)
IFN: GM661_17635(nuoF)
AAR: Acear_2300
HPRF: HLPR_07950(nuoE_2) HLPR_07970(nuoF_2) HLPR_07990(fdhF)
FMA: FMG_1154
AVG: I6H45_01925 I6H45_01930(fdhF)
AOB: I6H46_04955 I6H46_04960(fdhF)
MHAP: JFY71_05445 JFY71_05450(nuoF) JFY71_05455 JFY71_05465(fdhF)
CAD: Curi_c29370(fdhF1) Curi_c29380(fdhF2) Curi_c29390(hydA1) Curi_c29400(hydB) Curi_c29410(hydC)
SPOA: EQM13_18010
KPAR: JL105_10665(nuoE)
CAZO: G3A45_11640(nuoE)
TIS: P3962_10310(nuoE) P3962_10670(fdhF) P3962_10675 P3962_10680 P3962_10685(nuoE)
TIZ: RBU61_19095(nuoE) RBU61_19100 RBU61_19105 RBU61_19110(fdhF)
ECOU: M1R54_06655
AHQ: NMU03_11380
TUR: AT726_09480
TSG: HLK68_09320
TBB: J0J69_12725
TSF: NQ543_04470
CALK: HUE98_01260(fdhF) HUE98_04890(fdhF) HUE98_06660(nuoE)
MANR: MPAN_013440(hymB) MPAN_013510(hymA)
MBJ: KQ51_00316(hndA_1)
XCL: G4Z02_04360(nuoF) G4Z02_04395
LEK: hrd7_26570
TFLA: O0235_13795(fdhF)
TANT: KNN15_11225(fdhF)
BPIT: BPIT_04230
JET: L3J17_15120(fdhF)
SASS: MUG09_12710
CSOM: MKD34_00640(fdhF) MKD34_10885(fdhF)
ANF: AQPE_5013
HDS: HSR122_2943(nuoF) HSR122_2944(yjgC)
 » show all
Reference
1  [PMID:23872566]
  Authors
Wang S, Huang H, Kahnt J, Thauer RK
  Title
Clostridium acidurici electron-bifurcating formate dehydrogenase.
  Journal
Appl Environ Microbiol 79:6176-9 (2013)
DOI:10.1128/AEM.02015-13
  Sequence
[cad:Curi_c29410 Curi_c29400 Curi_c29390 Curi_c29380]
Other DBs
ExplorEnz - The Enzyme Database: 1.17.1.11
IUBMB Enzyme Nomenclature: 1.17.1.11
ExPASy - ENZYME nomenclature database: 1.17.1.11
BRENDA, the Enzyme Database: 1.17.1.11

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Chemical substance (7)   
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Chemical reaction (2)   
   KEGG REACTION (1)   
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   KEGG GENES (154)   
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