KEGG ENZYME: 1.17.3.3

ENZYME: 1.17.3.3

Entry

EC 1.17.3.3                 Enzyme

Name

6-hydroxynicotinate dehydrogenase;
6-hydroxynicotinic acid hydroxylase;
6-hydroxynicotinic acid dehydrogenase;
6-hydroxynicotinate hydroxylase;
6-hydroxynicotinate:O2 oxidoreductase

Class

Oxidoreductases;
Acting on CH or CH2 groups;
With oxygen as acceptor

Sysname

6-hydroxynicotinate:oxygen oxidoreductase

Reaction(IUBMB)

6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2 [RN:R07221]

Reaction(KEGG)

R07221

Substrate

6-hydroxynicotinate [CPD:C01020];
H2O [CPD:C00001];
O2 [CPD:C00007]

Product

2,6-dihydroxynicotinate [CPD:C15523];
H2O2 [CPD:C00027]

Comment

Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid.

History

EC 1.17.3.3 created 2004

Pathway

ec00760

Nicotinate and nicotinamide metabolism

Reference

Authors

Nagel, M. and Andreesen, J.R.

Title

Molybdenum-dependent degradation of nicotinic acid by Bacillus sp. DSM 2923.

Journal

FEMS Microbiol Lett 59:147-152 (1989)

Reference

Authors

Nagel, M. and Andreesen, J.R.

Title

Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini.

Journal

Arch Microbiol 154:605-613 (1990)

Other DBs

ExplorEnz - The Enzyme Database:

1.17.3.3

IUBMB Enzyme Nomenclature:

1.17.3.3

ExPASy - ENZYME nomenclature database:

1.17.3.3

BRENDA, the Enzyme Database:

1.17.3.3

CAS:	122191-32-6

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (9)   

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