Entry
Name
3-oxo-Delta1-steroid hydratase/dehydrogenase;
atcABC (gene names)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With unknown physiological acceptors
BRITE hierarchy
Sysname
3-oxo-Delta1-steroid:acceptor 1-oxidoreductase
Reaction(IUBMB)
a 3-oxo-Delta1-steroid + H2O + acceptor = a steroid 1,3-dione + reduced acceptor (overall reaction) [RN:
R12678 ];
(1a) a 3-oxo-Delta1-steroid + H2O = a 1-hydroxy-3-oxo-steroid [RN:
R12679 ];
(1b) a 1-hydroxy-3-oxo-steroid + acceptor = a steroid 1,3-dione + reduced acceptor [RN:
R12680 ]
Reaction(KEGG)
Substrate
Product
steroid 1,3-dione [CPD:
C22326 ];
reduced acceptor [CPD:
C00030 ];
1-hydroxy-3-oxo-steroid [CPD:
C22327 ]
Comment
A molybdenum enzyme. The enzyme, characterized from the bacterium Steroidobacter denitrificans, is involved in the anaetrobic degradation of steroids. It is specific to 3-oxo-Delta1-steroids such as androsta-1-ene-3,17-dione and Delta1-dihydrotestosterone and does not act on 3-oxo-Delta4-steroids.
History
EC 1.17.99.11 created 2020
Orthology
K24716 3-oxo-Delta1-steroid hydratase/dehydrogenase large subunit
K24717 3-oxo-Delta1-steroid hydratase/dehydrogenase medium subunit
K24718 3-oxo-Delta1-steroid hydratase/dehydrogenase small subunit
Genes
SDF : ACG33_03370 ACG33_03375 ACG33_03390
DOE : DENOEST_2087 DENOEST_2088 DENOEST_2089(cutS) DENOEST_2108 DENOEST_2110(cutS) DENOEST_2111(cutM) DENOEST_3658
AZI : AzCIB_1523 AzCIB_1524 AzCIB_1525
AZD : CDA09_10040 CDA09_10045 CDA09_10050
APOL : K9D25_22075 K9D25_22080
MOG : MMB17_21635 MMB17_21640
SGRG : L0C25_00110 L0C25_23810
ACTQ : OG417_37235 OG417_37245
ACTY : OG774_11415 OG774_11420
SBAE : DSM104329_04640(cdhC_2) DSM104329_05421(cutL_5)
HAXY : NGM07_22765 NGM07_23620
» show all
Taxonomy
Reference
Authors
Yang FC, Chen YL, Tang SL, Yu CP, Wang PH, Ismail W, Wang CH, Ding JY, Yang CY, Yang CY, Chiang YR.
Title
Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment.
Journal
Sequence
Other DBs