KEGG ENZYME: 1.18.1.4

ENZYME: 1.18.1.4

Entry

EC 1.18.1.4                 Enzyme

Name

rubredoxin---NAD(P)+ reductase;
rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase;
rubredoxin-nicotinamide adenine;
dinucleotide phosphate reductase;
NAD(P)+-rubredoxin oxidoreductase;
NAD(P)H-rubredoxin oxidoreductase

Class

Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor

Sysname

rubredoxin:NAD(P)+ oxidoreductase

Reaction(IUBMB)

2 reduced rubredoxin + NAD(P)+ + H+ = 2 oxidized rubredoxin + NAD(P)H [RN:R02000 R02002]

Reaction(KEGG)

R02000 R02002

Substrate

reduced rubredoxin [CPD:C00340];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H+ [CPD:C00080]

Product

oxidized rubredoxin [CPD:C00435];
NADH [CPD:C00004];
NADPH [CPD:C00005]

Comment

The enzyme from Pyrococcus furiosus requires FAD. It reduces a number of electron carriers, including benzyl viologen, menadione and 2,6-dichloroindophenol, but rubredoxin is the most efficient. Ferredoxin is not utilized.

History

EC 1.18.1.4 created 1984, modified 2001, modified 2011

Pathway

ec00071

Fatty acid degradation

Orthology

K00530

rubredoxin---NAD(P)+ reductase

Genes

TMA:

TM0754

TMM:	Tmari_0755

TMI:	THEMA_00880

TMW:

THMA_0773

TMQ:

THMB_0773

TMX:

THMC_0773

TPT:

Tpet_0175

TNP:

Tnap_0552

TRQ:

TRQ2_0173

TNA:

CTN_1828

THQ:	T2812B_00875

THZ:	CELL2_00915

THR:	TRQ7_00885

PFU:

PF1197

PFI:

PFC_05200

TKO:

TK0828

TON:

TON_0865

TSI:

TSIB_1897

TBA:	TERMP_00352

TLT:

OCC_12416

THS:

TES1_0424

THV:	ADU37_CDS20250

TPEP:

A0127_00970

TCE:	A3L02_02820

TBS:	A3L01_04970

THH:	CDI07_04935

TSL:	A3L11_09190

TTD:	A3L14_07295

TPRF:

A3L09_06335

TPAF:

A3L08_08235

TIC:	FH039_06775

TCQ:	TIRI35C_1294

THEM:

FPV09_02670

THEI:

K1720_02260

PPAC:

PAP_03325

» show all

Reference

1 [PMID:6274224]

Authors

Petitdemange H, Blusson H, Gay R.

Title

Detection of NAD(P)H--rubredoxin oxidoreductases in Clostridia.

Journal

Anal Biochem 116:564-70 (1981)
DOI:10.1016/0003-2697(81)90403-6

Reference

2 [PMID:10464233]

Authors

Ma K, Adams MW.

Title

A hyperactive NAD(P)H:Rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus.

Journal

J Bacteriol 181:5530-3 (1999)
DOI:10.1128/JB.181.17.5530-5533.1999

Other DBs

ExplorEnz - The Enzyme Database:

1.18.1.4

IUBMB Enzyme Nomenclature:

1.18.1.4

ExPASy - ENZYME nomenclature database:

1.18.1.4

BRENDA, the Enzyme Database:

1.18.1.4

CAS:	80237-97-4

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (35)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (4)   
All databases (55)   

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