KEGG ENZYME: 1.2.1.65

ENZYME: 1.2.1.65

Entry

EC 1.2.1.65                 Enzyme

Name

salicylaldehyde dehydrogenase

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

salicylaldehyde:NAD+ oxidoreductase

Reaction(IUBMB)

salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+ [RN:R02941]

Reaction(KEGG)

R02941

Substrate

salicylaldehyde [CPD:C06202];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Product

salicylate [CPD:C00805];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Involved in the naphthalene degradation pathway in some bacteria.

History

EC 1.2.1.65 created 2000, modified 2011

Pathway

ec00626

Naphthalene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00152

salicylaldehyde dehydrogenase

Genes

PPI:	ND058(nahF)

PFK:	PFAS1_28625

PSC:	A458_06710

PSTU:

UIB01_22640

PBM:	CL52_14625

RMN:	TK49_07965

BMK:

DM80_1446

PARB:

CJU94_38645

PNA:

Pnap_2482

Reference

1 [PMID:1447127]

Authors

Eaton RW, Chapman PJ

Title

Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions.

Journal

J Bacteriol 174:7542-54 (1992)
DOI:10.1128/JB.174.23.7542-7554.1992

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.65

IUBMB Enzyme Nomenclature:

1.2.1.65

ExPASy - ENZYME nomenclature database:

1.2.1.65

UM-BBD (Biocatalysis/Biodegradation Database):

1.2.1.65

BRENDA, the Enzyme Database:

1.2.1.65

CAS:	55354-34-2

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