Entry
Name
succinate-semialdehyde dehydrogenase (acylating);
succinyl-coA reductase;
coenzyme-A-dependent succinate-semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
succinate semialdehyde + CoA + NADP+ = succinyl-CoA + NADPH + H+ [RN:
R09280 ]
Reaction(KEGG)
Substrate
Product
Comment
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation [1], and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].
History
EC 1.2.1.76 created 2009
Pathway
ec00720 Carbon fixation pathways in prokaryotes
ec01120 Microbial metabolism in diverse environments
Orthology
K15017 malonyl-CoA/succinyl-CoA reductase (NADPH)
K18119 succinate-semialdehyde dehydrogenase
Genes
CPRF : K7H06_01435 K7H06_15520
CRAS : KVH43_03680 KVH43_07650
PFAA : MM59RIKEN_18180(sucD_1) MM59RIKEN_18920(sucD_2) MM59RIKEN_21990(sucD_3) MM59RIKEN_24180(sucD_4) MM59RIKEN_28330(sucD_5) MM59RIKEN_28340(sucD_6)
CHYL : CE91St63_27760(sucD)
CPRO : CPRO_14650(sucD_1) CPRO_16270(sucD_2)
PDF : CD630DERM_23420(sucD)
PCRE : NCTC12858_01805(sucD)
PCAG : NCTC12856_01246(sucD)
PSOE : CE91St14_12650(sucD)
STO : STK_00640 STK_21710(mcr_scr)
SOH : D1869_11875(asd) D1869_14740
SSO : SSO1629(gapN-1) SSO1842(gapN-2) SSO2178(asd-2)
SSHI : J5U23_00989 J5U23_02098
SCAS : SACC_11800 SACC_21720
SAI : Saci_1738 Saci_2147 Saci_2370
SACN : SacN8_08450 SacN8_10450 SacN8_11535
SACR : SacRon12I_08465 SacRon12I_10705 SacRon12I_11780
SACS : SUSAZ_08265 SUSAZ_09800 SUSAZ_11160
SIS : LS215_0550 LS215_2961
SIA : M1425_1049 M1425_2796
SIM : M1627_1112 M1627_2848
SIY : YG5714_1027 YG5714_2976
SIN : YN1551_1850 YN1551_2101 YN1551_3167
SII : LD85_0963 LD85_1154 LD85_3126
SULA : BFU36_00640 BFU36_10310
SULE : GFS03_01510(asd) GFS03_05485
SULO : GFS33_06710(asd) GFS33_10785
SULL : EWF20_01070 EWF20_13035(asd)
MSE : Msed_0709 Msed_1119 Msed_1774
MEMJ : MJ1HA_0819 MJ1HA_1248 MJ1HA_2026
MHK : DFR87_03300(asd) DFR87_09790 DFR87_12125
MPRU : DFR88_00930 DFR88_03035(asd) DFR88_09350
MTEN : GWK48_02495 GWK48_08305(asd)
MJN : MjAS7_1475 MjAS7_2925
AMAN : B6F84_02355 B6F84_04975 B6F84_05470
ABRI : DFR85_01565(asd) DFR85_12665 DFR85_14580
CSTY : KN1_05910 KN1_13950
» show all
Taxonomy
Reference
Authors
Sohling B, Gottschalk G
Title
Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri.
Journal
Sequence
Reference
Authors
Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G
Title
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.
Journal
Reference
Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.76
ExPASy - ENZYME nomenclature database: 1.2.1.76