KEGG ENZYME: 1.2.1.78

ENZYME: 1.2.1.78

Entry

EC 1.2.1.78                 Enzyme

Name

2-formylbenzoate dehydrogenase;
2-carboxybenzaldehyde dehydrogenase;
2CBAL dehydrogenase;
PhdK

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2-formylbenzoate:NAD+ oxidoreductase

Reaction(IUBMB)

2-formylbenzoate + NAD+ + H2O = o-phthalic acid + NADH + H+ [RN:R05643]

Reaction(KEGG)

R05643

Substrate

2-formylbenzoate [CPD:C03057];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Product

o-phthalic acid [CPD:C01606];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme is involved in phenanthrene degradation.

History

EC 1.2.1.78 created 2010

Pathway

ec00624

Polycyclic aromatic hydrocarbon degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K18275

2-formylbenzoate dehydrogenase

Genes

SENP:

KHA73_20375

SLIG:

GTU79_17835

HSX:	HNO51_14960

PPAI:

E1956_29490 E1956_44080

CHEA:

PVE73_08100

NKI:	KW403_13540

TLU:	R1T41_00625

MMAN:

MMAN_42220(gbsA)

MMC:

Mmcs_1663

MKM:	Mkms_1687 Mkms_5636

MJL:

Mjls_1636

MYE:	AB431_15525

MGAU:

MGALJ_00300

MVA:

Mvan_0522

MGI:

Mflv_0643

MSP:	Mspyr1_01810

MRH:	MycrhN_3178

MTY:	MTOK_55630(dhaS)

MGAD:

MGAD_31960(betB)

MMON:

EWR22_08465 EWR22_21605

MPAE:

K0O64_27450

MCRO:

MI149_00805

TSD:	MTP03_03750

SBAT:

G4Z16_01300

MSED:

E3O41_13870

ASUF:

MNQ99_01420

APN:	Asphe3_40220

NMAR:

HPC71_10560

AGRA:

AGRA3207_001969

ACTQ:

OG417_26405

NFS:	OIE67_21595

ARHD:

VSH64_09850 VSH64_10970 VSH64_15770

DROS:

Drose_13945

RMAR:

GBA65_17430

VAB:

WPS_11900

» show all

Reference

1 [PMID:9335300]

Authors

Iwabuchi T, Harayama S

Title

Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7.

Journal

J Bacteriol 179:6488-94 (1997)
DOI:10.1128/JB.179.20.6488-6494.1997

Sequence

[ag:BAA23265]

Reference

Authors

Kiyohara, H., Nagao, K. and Yano, K.

Title

Isolation and some properties of NAD-linked 2-carboxybenzaldehyde dehydrogenase in Alcaligenes faecalis AFK 2 grown on phenanthrene.

Journal

J Gen Appl Microbiol 27:443-455 (1981)

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.78

IUBMB Enzyme Nomenclature:

1.2.1.78

ExPASy - ENZYME nomenclature database:

1.2.1.78

BRENDA, the Enzyme Database:

1.2.1.78

DBGET integrated database retrieval system