KEGG   ENZYME: 1.2.1.80
Entry
EC 1.2.1.80                 Enzyme                                 
Name
long-chain acyl-[acyl-carrier-protein] reductase;
long-chain acyl-[acp] reductase;
fatty acyl-[acyl-carrier-protein] reductase;
acyl-[acp] reductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
long-chain-aldehyde:NAD(P)+ oxidoreductase (acyl-[acyl-carrier protein]-forming)
Reaction(IUBMB)
a long-chain aldehyde + an [acyl-carrier protein] + NAD(P)+ = a long-chain acyl-[acyl-carrier protein] + NAD(P)H + H+ [RN:R09484 R09485]
Reaction(KEGG)
R09484 R09485
Substrate
long-chain aldehyde [CPD:C00609];
[acyl-carrier protein] [CPD:C00229];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
long-chain acyl-[acyl-carrier protein] [CPD:C20683];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction in the opposite direction. This enzyme, purified from the cyanobacterium Synechococcus elongatus PCC 7942, catalyses the NAD(P)H-dependent reduction of an activated fatty acid (acyl-[acp]) to the corresponding aldehyde. Together with EC 4.1.99.5, octadecanal decarbonylase, it is involved in alkane biosynthesis. The natural substrates of the enzyme are C16 and C18 activated fatty acids. Requires Mg2+.
History
EC 1.2.1.80 created 2011
Orthology
K14330  fatty aldehyde-generating acyl-ACP reductase
Genes
VFF: VITFI_CDS1482
DALK: DSCA_06500
BTS: Btus_0602
TUM: CBW65_22005
TAB: CIG75_07705
EFF: skT53_34800
CACE: CACET_c35020
CFM: BJL90_03040
CALE: FDN13_03935
DCA: Desca_0167
PTH: PTH_0261
DRM: Dred_0173
DRU: Desru_0253
DFG: B0537_01670
DAE: Dtox_0249
DKU: Desku_3197
DAU: Daud_0129
TFR: BR63_14590
FWA: DCMF_21965
DGI: Desgi_0316
HMO: HM1_0645
HCV: FTV88_2683
ACAE: HYG86_08625
SAY: TPY_0442
SAP: Sulac_0405
STHR: BXT84_04875
CTHM: CFE_0104
AMT: Amet_4316
AOE: Clos_2418
GFE: Gferi_18430
TTE: TTE2374
TEX: Teth514_0808
THX: Thet_2108
TPD: Teth39_0316
TIT: Thit_2042
TMT: Tmath_1999
TBO: Thebr_0326
TWI: Thewi_2315
TKI: TKV_c21150
CHY: CHY_2367
ADG: Adeg_1649
TPZ: Tph_c26210
TTM: Tthe_0378
TTO: Thethe_00327
TXY: Thexy_0276
TSH: Tsac_0954
AAUT: ACETAC_10295
TEP: TepRe1_2126
TAE: TepiRe1_2289
TOC: Toce_2079
NTH: Nther_0115
HOR: Hore_00730
HALS: D7D81_00030
IFN: GM661_16005
AAR: Acear_0121
HHL: Halha_0143
AFT: BBF96_15620
KME: H0A61_01195(pigE_1)
PUF: UFO1_0509
PFT: JBW_03936
MANA: MAMMFC1_01979
STED: SPTER_48640(hemA_2)
PFAC: PFJ30894_02364
CFI: Celf_0203
ORN: DV701_10430
MGG: MPLG2_3309
SYN: sll0209
SYZ: MYO_122770
SYY: SYNGTS_2251(sll0209)
SYT: SYNGTI_2250(sll0209)
SYS: SYNPCCN_2249(sll0209)
SYQ: SYNPCCP_2249(sll0209)
SYJ: D082_05320
SYO: C7I86_11770
SYC: syc0051_d
SYU: M744_09025
SYF: Synpcc7942_1594
SYD: Syncc9605_0729
SYE: Syncc9902_1634
SYG: sync_1989
SYR: SynRCC307_1585
SYX: SynWH7803_0655
CYA: CYA_0414
CYB: CYB_2441
SYNE: Syn6312_1511
SYNP: Syn7502_03277
SYNK: KR100_05370
SYNR: KR49_12750
SYND: KR52_13295
SYH: Syncc8109_1975
SYNW: SynWH8103_01988(cACR)
SYNC: CB0101_04555
SYNY: BM449_13775
DSL: Dacsa_2180
SYW: SYNW1737
CGC: Cyagr_0038
CYI: CBM981_0850
PMA: Pro_0533
PMM: PMM0533
PMT: PMT_1230
PMN: PMN2A_1864
PMI: PMT9312_0533
PMB: A9601_05891
PMC: P9515_05971
PMF: P9303_07811
PMG: P9301_05591
PMH: P9215_06141
PMJ: P9211_05361
PME: NATL1_05891
PRC: EW14_0579
PRM: EW15_0630
WNA: KA717_25575
CMP: Cha6605_5417
CYN: Cyan7425_0399
CEP: Cri9333_4415
TVN: NIES2134_112430
SLW: BRW62_00115
AMR: AM1_4042
ACAM: HRE53_16685
TEL: tll1312
THN: NK55_03190
THEC: FFX45_09775
TSZ: OOK60_04770
LEN: LEP3755_23580
LET: O77CONTIG1_02794
LBO: LBWT_14410
KOV: K9N68_11175
LSC: KIK02_13610
LSK: J5X98_02330
PSEU: Pse7367_3627
PSER: ABRG53_3066
PGX: OA858_21170
THEU: HPC62_16890
TOG: HNI00_00015
TSIN: OXH18_21170
GLP: Glo7428_0151
GDU: P0S91_16975
GEE: GM3708_2119
CAN: Cyan10605_1068
MAR: MAE_53080
MPK: VL20_1524
MIQ: B5D77_20955
MVZ: myaer102_25850
HAO: PCC7418_0960
ENN: FRE64_14815
CYU: UCYN_05800
CYT: cce_1430
CWA: CwatDRAFT_3385
CYP: PCC8801_0872
CYH: Cyan8802_0898
TER: Tery_2279
ARP: NIES39_M01920
PAGH: NIES204_11580
PPSU: NO713_00868
PRUN: PCC7821_01464
OXY: HCG48_15930
MVAG: D0A34_07470
LFS: HFV01_13725
OAC: Oscil6304_2073
ONI: Osc7112_0945
PHOR: JWS08_08195
PYH: NEA10_04670
MIC: Mic7113_4537
GEI: GEI7407_1565
GVI: gll3145
GLJ: GKIL_0726(hemA)
GML: ISF26_16240
ANA: alr5284
NPU: Npun_R1710
NOS: Nos7107_1027
NOP: Nos7524_4305
NON: NOS3756_54750
NFL: COO91_03201
NOE: CLI64_08840
NSH: GXM_04006
NED: HUN01_28130
NPZ: ACX27_13680
AVA: Ava_2534
NAZ: Aazo_3370
ANB: ANA_C11209
ACY: Anacy_3390
AWA: AA650_00530
ANN: EH233_18780
CSG: Cylst_0696
RSIN: B6N60_03103
HBQ: QI031_08530
CALO: Cal7507_5585
CALT: Cal6303_4370
CALH: IJ00_07395
CALN: NIES2098_27730
CALS: NIES3974_39180
RIV: Riv7116_3791
FIS: FIS3754_06320
NSPH: BDGGKGIB_04212
DOU: BMF77_02262
DFS: HGD76_06325
DHT: NG743_14495
CCUR: IAR63_11975
CRK: L3I90_01360
AFLO: HEQ12_03500
STOQ: K2F26_22850
AEE: IM676_14760
RCS: NIES932_03040
TOQ: HCG51_19275
ALAX: NIES50_14950
NCN: BZZ01_14985
CTHE: Chro_1553
GLT: GlitD10_1038
GCY: LQF76_09535
CEO: ETSB_0189
CER: RGRSB_0136
CEEC: P3F56_00730
THUG: KNN16_02140
DMR: Deima_1953
DCH: SY84_14815
DGA: DEGR_12050
CCZ: CCALI_02334
FGI: OP10G_3716
NPY: NPRO_00590
RHOZ: GXP67_04260
DFE: Dfer_5680
ADD: HUW48_09010
CPO: COPRO5265_1114
NMV: NITMOv2_1388
 » show all
Reference
1  [PMID:20671186]
  Authors
Schirmer A, Rude MA, Li X, Popova E, del Cardayre SB
  Title
Microbial biosynthesis of alkanes.
  Journal
Science 329:559-62 (2010)
DOI:10.1126/science.1187936
  Sequence
[syf:Synpcc7942_1594]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.80
IUBMB Enzyme Nomenclature: 1.2.1.80
ExPASy - ENZYME nomenclature database: 1.2.1.80
BRENDA, the Enzyme Database: 1.2.1.80

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Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (2379)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (224)   
   KEGG MGENES (1685)   
   RefGene (469)   
Protein sequence (1562)   
   UniProt (724)   
   SWISS-PROT (2)   
   RefSeq(pep) (825)   
   PDBSTR (11)   
DNA sequence (2026)   
   RefSeq(nuc) (1722)   
   GenBank (158)   
   EMBL (146)   
3D Structure (4)   
   PDB (4)   
Protein domain (3)   
   InterPro (3)   
All databases (5986)   

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