| Entry |
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| Name |
3-succinoylsemialdehyde-pyridine dehydrogenase
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase
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| Reaction(IUBMB) |
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ [RN: R10105]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.
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| History |
EC 1.2.1.83 created 2012
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| Pathway |
| ec00760 | Nicotinate and nicotinamide metabolism |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K19700 | 3-succinoylsemialdehyde-pyridine dehydrogenase |
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| Genes |
| ALCA: | ASALC70_03936(ald_1) |
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| Reference |
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| Authors |
Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W |
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| Title |
Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.1.83 |
| ExPASy - ENZYME nomenclature database: | 1.2.1.83 |
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