KEGG ENZYME: 1.2.1.89

ENZYME: 1.2.1.89

Entry

EC 1.2.1.89                 Enzyme

Name

D-glyceraldehyde dehydrogenase (NADP+);
glyceraldehyde dehydrogenase;
GADH

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glyceraldehyde:NADP+ oxidoreductase

Reaction(IUBMB)

D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+ [RN:R10615]

Reaction(KEGG)

R10615

Substrate

D-glyceraldehyde [CPD:C00577];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

D-glycerate [CPD:C00258];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme from the archaea Thermoplasma acidophilum and Picrophilus torridus is involved in the non-phosphorylative Entner-Doudoroff pathway. cf. EC 1.2.99.8, glyceraldehyde dehydrogenase (FAD-containing).

History

EC 1.2.1.89 created 2014

Pathway

ec00030

Pentose phosphate pathway

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K18128

D-glyceraldehyde dehydrogenase (NADP+)

Genes

TAC:

Ta0809

TVO:	TVG1076124(TVG1076124)

PTO:

PTO0332

FAC:	FACI_IFERC01G0706

AHO:

Ahos_0275

ACIH:

HS5_15570(aldA)

Reference

1 [PMID:16566751]

Authors

Jung JH, Lee SB

Title

Identification and characterization of Thermoplasma acidophilum glyceraldehyde dehydrogenase: a new class of NADP+-specific aldehyde dehydrogenase.

Journal

Biochem J 397:131-8 (2006)
DOI:10.1042/BJ20051763

Sequence

[tac:Ta0809]

Reference

2 [PMID:16458304]

Authors

Reher M, Schonheit P

Title

Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.

Journal

FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029

Sequence

[pto:PTO0332] [tac:Ta0809]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.89

IUBMB Enzyme Nomenclature:

1.2.1.89

ExPASy - ENZYME nomenclature database:

1.2.1.89

BRENDA, the Enzyme Database:

1.2.1.89

DBGET integrated database retrieval system