KEGG ENZYME: 1.2.1.90

ENZYME: 1.2.1.90

Entry

EC 1.2.1.90                 Enzyme

Name

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+];
non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (ambiguous);
GAPN

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glyceraldehyde-3-phosphate:NAD(P)+ oxidoreductase

Reaction(IUBMB)

D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O = 3-phospho-D-glycerate + NAD(P)H + 2 H+ [RN:R01058 R10860]

Reaction(KEGG)

R01058 R10860

Substrate

D-glyceraldehyde 3-phosphate [CPD:C00118];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

3-phospho-D-glycerate [CPD:C00197];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme is part of the modified Embden-Meyerhof-Parnas pathway of the archaeon Thermoproteus tenax. cf. EC 1.2.1.9 [glyceraldehyde-3-phosphate dehydrogenase (NADP+)].

History

EC 1.2.1.90 created 2014

Pathway

ec00010

Glycolysis / Gluconeogenesis

ec00030

Pentose phosphate pathway

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K18978

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

Genes

TAQU:

KDW03_05525

PFU:

PF0755

PFI:

PFC_02935

TKO:

TK0705

TSI:

TSIB_1868

TLT:

OCC_12546

TNU:

BD01_0877

THV:	ADU37_CDS19860

TCE:	A3L02_05455

TTD:	A3L14_07265

THEM:

FPV09_07270

THEI:

K1720_01165

PPAC:

PAP_03390

HAL:	VNG_0937G(gap)

HSL:	OE_2367F(aldH3)

HANR:

LJ422_03815

HHB:

Hhub_2122

HAGS:

JT689_05100

HABO:

JRZ79_03600

HNO:	LT974_05480 LT974_09800

HLU:	LT972_07680

HDO:	MUK72_07355

HALX:

M0R89_14390

HAXZ:

M0R88_14805

HAYC:

NGM10_01350

HAXY:

NGM07_02135

NMO:	Nmlp_1397(aldH2)

HALI:

BV210_12380

HSN:	DV733_08500

HAAD:

MW046_08360 MW046_16535

HRA:	EI982_02835

HALB:

EKH57_03600

HAE:	halTADL_1775

HTU:

Htur_1629

HSAL:

JMJ58_00455

HAKZ:

J0X25_14945

NMG:

Nmag_3488

NAT:

NJ7G_3347

NPE:	Natpe_2432

NVR:	FEJ81_11090

NPL:	FGF80_11110

NAY:	HYG81_14030

HALY:

HYG82_00810

HJT:	DVR14_02090

HLO:	J0X27_15795

HLR:	HALLA_11300

NAJ:	B1756_06275

NAG:	AArcMg_1817

NAN:	AArc1_1866

NARA:

QQ977_10575

NBG:	DV706_13160

NAS:	GCU68_13885

HDA:	BB347_04210

APE:	APE_1786.1(gapN)

ACJ:	ACAM_1119(gapN)

SMR:

Smar_0084

SHC:	Shell_0726

DKA:

DKAM_1444

DFD:	Desfe_0067

DMU:	Desmu_1044

TAG:

Tagg_1262

IAG:

Igag_1780

THG:	TCELL_0871

STO:	STK_24770(gapN)

SOH:	D1869_13560

SSO:	SSO3194(gapN-3)

SOL:

Ssol_0932

SSOA:

SULA_0965

SSOL:

SULB_0967

SSOF:

SULC_0966

SSHI:

J5U23_00303

SCAS:

SACC_31300

SAI:

Saci_0227

SACN:

SacN8_01100

SACR:

SacRon12I_01100

SACS:

SUSAZ_01140

SIS:	LS215_2328

SIA:	M1425_2165

SIM:	M1627_2245

SID:

M164_2168

SIY:	YG5714_2291

SIN:	YN1551_0624

SII:

LD85_2431

SIH:

SiH_2110

SIR:

SiRe_2042

SIC:

SiL_2017

SULA:

BFU36_06100

SULE:

GFS03_11790

SULO:

GFS33_03600

SULL:

EWF20_14560

MSE:

Msed_1298

MEMJ:

MJ1HA_1505

MCN:

Mcup_0943

MHK:	DFR87_12305

MPRU:

DFR88_11830

MTEN:

GWK48_00435

MJN:	MjAS7_2365

ABRI:

DFR85_14750

SACD:

HS1genome_1558

SAZO:

D1868_10855

CSTY:

KN1_14760

STEP:

IC006_2129

SMET:

RQ359_002109(gapN)

SAHS:

HS7_04650

PAS:

Pars_0554

POG:

Pogu_1837

CMA:

Cmaq_0979

TTN:	TTX_1169(gapN)

TUZ:

TUZN_1133

VDI:

Vdis_2334

VMO:

VMUT_0605

VSO:	Vsou_22700

THF:	MA03_02735

ASC:

ASAC_1423

ACIA:

SE86_04065

CLG:	Calag_1262

FFO:	FFONT_0138

CSU:	CSUB_C0048

NAA:

Nps_02395

NAER:

MJ1_0538

» show all

Reference

1 [PMID:9497334]

Authors

Brunner NA, Brinkmann H, Siebers B, Hensel R

Title

NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties.

Journal

J Biol Chem 273:6149-56 (1998)
DOI:10.1074/jbc.273.11.6149

Sequence

[ag:CAA71651]

Reference

2 [PMID:11354453]

Authors

Brunner NA, Siebers B, Hensel R

Title

Role of two different glyceraldehyde-3-phosphate dehydrogenases in controlling the reversible Embden-Meyerhof-Parnas pathway in Thermoproteus tenax: regulation on protein and transcript level.

Journal

Extremophiles 5:101-9 (2001)
DOI:10.1007/s007920100181

Sequence

[ag:CAA71651]

Reference

3 [PMID:11842090]

Authors

Pohl E, Brunner N, Wilmanns M, Hensel R

Title

The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax.

Journal

J Biol Chem 277:19938-45 (2002)
DOI:10.1074/jbc.M112244200

Sequence

[ag:CAA71651]

Reference

4 [PMID:15288789]

Authors

Lorentzen E, Hensel R, Knura T, Ahmed H, Pohl E

Title

Structural Basis of allosteric regulation and substrate specificity of the non-phosphorylating glyceraldehyde 3-Phosphate dehydrogenase from Thermoproteus tenax.

Journal

J Mol Biol 341:815-28 (2004)
DOI:10.1016/j.jmb.2004.05.032

Sequence

[ag:CAA71651]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.90

IUBMB Enzyme Nomenclature:

1.2.1.90

ExPASy - ENZYME nomenclature database:

1.2.1.90

BRENDA, the Enzyme Database:

1.2.1.90

DBGET integrated database retrieval system