Entry
Name
farnesal dehydrogenase;
AaALDH3
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
farnesal:NAD+ oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+
Substrate
Product
Comment
Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito).
History
EC 1.2.1.94 created 2015
Reference
Authors
Madhavan K, Conscience-Egli M, Sieber F, Ursprung H
Title
Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase.
Journal
Reference
Authors
Baker FC, Mauchamp B, Tsai LW, Schooley DA
Title
Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta.
Journal
J Lipid Res 24:1586-94 (1983)
Reference
Authors
Rivera-Perez C, Nouzova M, Clifton ME, Garcia EM, LeBlanc E, Noriega FG
Title
Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.94
ExPASy - ENZYME nomenclature database: 1.2.1.94